The impact of arteriolosclerosis on cognitive impairment in decedents without severe dementia from the National Alzheimer's Coordinating Center DOI Creative Commons
Cellas A. Hayes, Christina B. Young, Carla Abdelnour

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(3)

Published: March 1, 2025

Alzheimer's disease neuropathologic change (ADNC), Lewy body (LBD), and vascular neuropathologies occur together. Previous studies have been limited by a large majority of participants with severe dementia or advanced stages pathologies, which limits the detectability cognitive effects from neuropathologies. Using neuropathology data National Coordinating Center, we examined association scores in without (N = 1526) using multivariable linear regression. Controlling for age, sex, education, LBD, ADNC, arteriolosclerosis was associated lower memory (β -0.16 ± 0.06, p < 0.001), executive function -0.25 0.05, language -0.20 0.001). The remained when controlling risk factors. Vascular exhibit distinct relationships cognition. Arteriolosclerosis is an independent contributor to Further research should be conducted on whether can serve as surrogate marker decline early stages. In individuals who do not dementia, are common, combination pathologies heterogeneous convenience sample Disease Research Center that reported all elements this investigation. several domain scores, including memory, function, disease. These results reinforce importance pathology cognition among people along spectrum.

Language: Английский

Glymphatic imaging: a critical look at the DTI-ALPS index DOI Creative Commons
Geir Ringstad

Neuroradiology, Journal Year: 2024, Volume and Issue: 66(2), P. 157 - 160

Published: Jan. 10, 2024

Language: Английский

Citations

67
Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method DOI Creative Commons
Toshiaki Taoka, Rintaro Ito, Rei Nakamichi

et al.

Magnetic Resonance in Medical Sciences, Journal Year: 2024, Volume and Issue: 23(3), P. 268 - 290

Published: Jan. 1, 2024

More than 5 years have passed since the Diffusion Tensor Image Analysis ALong Perivascular Space (DTI-ALPS) method was proposed with intention of evaluating glymphatic system. This is handy due to its noninvasiveness, provision a simple index in straightforward formula, and possibility retrospective analysis. Therefore, ALPS adopted evaluate system for many disorders studies. The purpose this review look back discuss at moment.

Language: Английский

Citations

64
The relationship between inflammation, impaired glymphatic system, and neurodegenerative disorders: A vicious cycle DOI Creative Commons
Yu Cai, Yin Zhang,

Shuo Leng

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 192, P. 106426 - 106426

Published: Feb. 6, 2024

The term "glymphatic" emerged roughly a decade ago, marking pivotal point in neuroscience research. glymphatic system, glial-dependent perivascular network distributed throughout the brain, has since become focal of investigation. There is increasing evidence suggesting that impairment system appears to be common feature neurodegenerative disorders, and this exacerbates as disease progression. Nevertheless, factors contributing dysfunction across most disorders remain unclear. Inflammation, however, suspected play role. Dysfunction can lead significant accumulation protein waste products, which trigger inflammation. interaction between inflammation cyclical potentially synergistic. Yet, current research limited, there lack comprehensive models explaining association. In perspective review, we propose novel model inflammation, impaired function, interconnected vicious cycle. By presenting experimental from existing literature, aim demonstrate that: (1) aggravates dysfunction, (2) exacerbated progression, (3) progression promotes Finally, implication proposed discussed.

Language: Английский

Citations

17
Diffusion magnetic resonance imaging of cerebrospinal fluid dynamics: Current techniques and future advancements DOI
Adam M. Wright, Yu‐Chien Wu, Li Feng

et al.

NMR in Biomedicine, Journal Year: 2024, Volume and Issue: 37(9)

Published: May 7, 2024

Abstract Cerebrospinal fluid (CSF) plays a critical role in metabolic waste clearance from the brain, requiring its circulation throughout various brain pathways, including ventricular system, subarachnoid spaces, para‐arterial interstitial and para‐venous spaces. The complexity of CSF has posed challenge obtaining noninvasive measurements dynamics. assessment dynamics circulatory pathways is possible using diffusion magnetic resonance imaging (MRI) with optimized sensitivity to incoherent water movement across brain. This review presents an overview both established emerging MRI techniques designed measure their potential clinical applications. discussion offers insights into optimization acquisition parameters enhance specificity metrics on underlying Lastly, we emphasize importance cautious interpretations diffusion‐based imaging, especially when differentiating between tissue‐ fluid‐related changes or elucidating structural versus functional alterations.

Language: Английский

Citations

13
Simvastatin alleviates glymphatic system damage via the VEGF-C/VEGFR3/PI3K-Akt pathway after experimental intracerebral hemorrhage DOI Creative Commons
Junbo Liao,

Yingxing Duan,

Yaxue Liu

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 216, P. 111045 - 111045

Published: Aug. 5, 2024

Current clinical practice primarily relies on surgical intervention to remove hematomas in patients with intracerebral hemorrhage (ICH), given the lack of effective drug therapies. Previous research indicates that simvastatin (SIM) may enhance hematoma absorption and resolution acute phase ICH, though precise mechanisms remain unclear. Recent findings have highlighted glymphatic system (GS) as a crucial component intracranial cerebrospinal fluid circulation, playing significant role clearance post-ICH. This study investigates link between SIM efficacy GS. Our experimental results show alleviates GS damage ICH-induced rats, resulting improved outcomes such reduced brain edema, neuronal apoptosis, degeneration. Further analysis reveals SIM's effects are mediated through VEGF-C/VEGFR3/PI3K-Akt pathway. advances our understanding mechanism promoting underscores potential targeting for ICH treatment.

Language: Английский

Citations

12
Impaired glymphatic function as a biomarker for subjective cognitive decline: An exploratory dual cohort study DOI Creative Commons
Yuxia Li,

Luyao Wang,

Jiayi Zhong

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(9), P. 6542 - 6555

Published: Aug. 6, 2024

Abstract BACKGROUND Subjective cognitive decline (SCD) has been recognized as a potential risk stage for progression to Alzheimer's disease (AD), while glymphatic dysfunction is considered an important characteristic of AD. We hypothesize that occurs during the SCD stage, aiming discover biomarkers SCD. METHODS Participants from two independent studies, Sino Longitudinal Study on Cognitive Decline (SILCODE, n = 654) and Disease Neuroimaging Initiative (ADNI, 650), representing different ethnicities stages, were included assess function using diffusion tensor image analysis along perivascular space (DTI‐ALPS). RESULTS Abnormal with ALPS index demonstrating excellent classification performance normal controls (area under receiver operating curve [AUC] SILCODE 0.816, AUC ADNI 0.797). Lower indicates higher progression, which negatively correlated Questionnaire 9 scores amyloid positron emission tomography burden. DISSCUSION Our study suggests serve biomarker Highlights Glymphatic characterized by (ALPS) becomes abnormal in subjective (SCD), earliest symptomatic manifestation preclinical (AD). The demonstrates East Asian Western cohorts. lower show clinical progression. closely associated serval scales beta

Language: Английский

Citations

10
Quantitative Evaluation of Dynamic Glymphatic Activity in Insomnia: A Contrast-enhanced Synthetic MRI Study DOI

Ruifang Xiong,

Jie Feng,

Hanting Zhu

et al.

Sleep Medicine, Journal Year: 2025, Volume and Issue: 127, P. 16 - 23

Published: Jan. 2, 2025

Language: Английский

Citations

1
Assessment of glymphatic function and white matter integrity in children with autism using multi-parametric MRI and machine learning DOI
Miaoyan Wang, Ke He, Lili Zhang

et al.

European Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Language: Английский

Citations

1
DTI-ALPS index decreased in patients with Type 2 Diabetes Mellitus DOI Creative Commons

Shuncheng Yu,

Jiang Hongjun,

Langxuan Yu

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: May 22, 2024

Backgrounds Type 2 Diabetes Mellitus (T2DM) has become a significant global public health issue, characterized by rising prevalence and associated deficits across multiple organ systems. Our study aims to utilize the DTI-ALPS technique assess change of ALPS index in T2DM patients, explore whether such changes are correlated with cognition level diffusion parameters. Methods The involved 41 patients (mean age, 60.49 ± 8.88 years) 27 healthy controls 58.00 7.63 years). All subjects underwent MRI examination, cognitive assessment, laboratory tests. Tract-based spatial statistics (TBSS) was used evaluate white matter changes. GLM performed check difference between HC groups. Spearman correlation analysis partial were analyze properties &amp; scores. Results results show that lower patients. MoCA score significantly index. Patients had increase both mean diffusivity (MD) radial (RD) decrease fractional anisotropy (FA) compared group. Conclusion suggest is decreased associates level.

Language: Английский

Citations

7
Glymphatic function from diffusion-tensor MRI to predict conversion from mild cognitive impairment to dementia in Parkinson’s disease DOI Creative Commons

Huize Pang,

Juzhou Wang,

Ziyang Yu

et al.

Journal of Neurology, Journal Year: 2024, Volume and Issue: 271(8), P. 5598 - 5609

Published: June 24, 2024

Abstract Background Although brain glymphatic dysfunction is a contributing factor to the cognitive deficits in Parkinson’s disease (PD), its role longitudinal progression of remains unknown. Objective To investigate function PD with mild impairment (MCI) that progresses dementia (PDD) and determine predictive value identifying individuals at high risk for developing dementia. Methods We included 64 patients meeting criteria MCI categorized them as either progressed PDD (converters) ( n = 29) or did not progress (nonconverters) 35), depending on whether they developed during follow-up. Meanwhile, 35 age- gender-matched healthy controls (HC) were included. Bilateral diffusion-tensor imaging analysis along perivascular space (DTI-ALPS) indices enlarged spaces (EPVS) volume fraction bilateral centrum semiovale, basal ganglia (BG), midbrain compared among three groups. Correlations DTI-ALPS index EPVS, well performance analyzed. Additionally, we investigated mediation effect EPVS function. Results converters had lower composites scores executive domains than nonconverters P < 0.001). Besides, significantly left hemisphere 0.001) larger BG-PVS 0.03) HC nonconverters. Lower increased associated worse global However, there was no significant mediating effect. Receiver operating characteristic revealed could effectively identify an area under curve (AUC) 0.850. Conclusion The reduction activity, measured by DTI-ALPS, potentially be used non-invasive indicator forecasting conversion before onset patients.

Language: Английский

Citations

7