Glymphatic dysfunction exacerbates cognitive decline by triggering cortical degeneration in Parkinson's disease: evidence from diffusion-tensor MRI.

PubMed, Journal Year: 2025, Volume and Issue: 7(1), P. fcaf029 - fcaf029

Published: Jan. 1, 2025

The glymphatic system may play a central role in cognitive impairment associated with Parkinson's disease, but its relationship regional cortical atrophy is not fully explored. To explore associations among dysfunction, degeneration and disease participants, we evaluated 51 participants documented (28 men; age, 61.65 ± 8.27 years) 30 age- sex-matched normal controls (11 59.2 5.90 who underwent 3.0-T MRI of the brain, including high-resolution T1-weighted imaging diffusion-tensor along perivascular space as surrogate for flow. Cortical grey matter volume was segmented automatically based on three-dimensional sequences. Cognitive function assessed by Mini-Mental State Examination. between decline revealed lower (1.45 0.17 versus 1.64 0.17, P < 0.0001) compared controls, indicating disturbed Glymphatic dysfunction scores (r = 0.54, 0.003). Diffusion-tensor values were positively specific regions (all P-values <0.05) temporal pole, posterior orbital gyrus, part inferior frontal operculum, operculum anterior cingulate gyrus. Mediation analysis within indicated that partially mediated integrity gyrus whereas distribution constitute link impairment.

Language: Английский

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Longitudinal changes of blood-brain barrier and transcytolemmal water exchange permeability in Alzheimer's disease mice: A non-contrast MRI study

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121141 - 121141

Published: March 1, 2025

Growing evidence suggests that Alzheimer's disease (AD) has been linked with the dysfunction of glymphatic system. Previous studies were primarily cross-sectional and focused on only one specific component, hindering understanding overall function in AD. We evaluated longitudinal changes multiple components system (blood-brain barrier (BBB) transcytolemmal water exchange (TWE) permeability) AD mice. Five female wild-type four 3 × Tg-AD mice from 5 to 13 months age scanned monthly using two non-contrast MRI techniques, water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST) diffusion-time-dependent kurtosis imaging (tDKI), yielding BBB TWE permeability. Immunostaining was used evaluate tight junction proteins associated structural integrity, aquaporin 4 (AQP4) related TWE, AQP4 perivascular space (PVS) polarization might represent PVS-parenchyma exchange. The relationship between pathology, as measured by amyloid beta (Aβ) tau deposition, also explored. Our results revealed significantly increased hippocampal permeability mouse brains, consistent histological findings reduced upregulated AQP4, which correlated each other can be predictive Aβ deposition. Impaired PVS found In conclusion, altered mice, these vivo validated pathologically, affect waste clearance neurofluid.

Language: Английский

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Perivascular space and white matter hyperintensities in Alzheimer’s disease: associations with disease progression and cognitive function

Alzheimer s Research & Therapy, Journal Year: 2025, Volume and Issue: 17(1)

Published: March 18, 2025

Alzheimer's disease (AD) is the leading cause of dementia, characterized by accumulation amyloid-beta (Aβ) and neurofibrillary tangles. Recent studies emphasize role vascular factors, including glymphatic system, in AD pathogenesis, particularly Aβ clearance. The diffusion tensor image analysis along perivascular space (DTI-ALPS; ALPS-Index) has emerged as a novel, non-invasive method to evaluate system vivo, showing insufficiency AD. This study aimed investigate alterations function individuals with versus healthy controls (HC), explore its association Aβ, cerebrovascular (CVD), white matter hyperintensities (WMH), cognitive function. DTI MRI data from three independent cohorts (ActiGliA: n = 16, Controls 18; DELCODE: 54, 67; ADNI: 43, 49) were used (PVS) integrity; potential biomarker for activity. DTI-Along Perivascular Space technique was measure water PVS providing an index assess efficiency system's waste clearance WMH load quantified FLAIR using lesion segmentation tool. We WMHs volume within our defined region interest (ROI) excluded participants any avoid confounding ALPS-Index. Associations cerebrospinal fluid (CSF) hallmark biomarkers, performance (MMSE) clinical severity (CDR) assessed. patients had significantly lower ALPS-Index vs. AD: mean 1.22, SD 0.12; Controls: 1.36, 0.14, p 0.004; 1.26, 0.18; 1.34, 0.2, 0.035; 1.08, 0.24; 1.19, 0.13, 0.008). associated CSF concentration, number MMSE CDR. WMH, found ROIs correlated negatively highlights DTI-ALPS-Index dysfunction It underscores importance considering factors pathogenesis diagnosis ROI could disturbances inaccurate indices.

Language: Английский

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Increased glymphatic system activity and thalamic vulnerability in drug-naive somatic depression: Evidenced by DTI-ALPS index

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: unknown, P. 103769 - 103769

Published: March 1, 2025

Language: Английский

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Inflammation and psychomotor retardation in depression: The moderating role of glymphatic system

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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