Development and validation of animal variant classification guidelines to objectively evaluate genetic variant pathogenicity in domestic animals

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 5, 2024

Assessing the pathogenicity of a disease-associated genetic variant in animals accurately is vital, both on population and individual scale. At level, breeding decisions based invalid DNA tests can lead to incorrect inclusion or exclusion compromise long-term health population, at level animal, treatment even life-ending decisions. Criteria determine are not standardized, i.e., no guidelines for animal variants available. Here, we aimed develop validate be used by community Mendelian disorders domestic classify categories standardized criteria. These so-called classification (AVCG) were those developed humans The American College Medical Genetics Genomics (ACMG). In direct comparison, 83% pathogenic correctly classified with ACMG, while this increased 92% AVCG. We described methods datasets benchmarking criteria identified most optimal silico effect predictor tools. As reproducibility was high, 72 known cats 40 other eight additional species.

Language: Английский

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Leopard Cats Occupied Human Settlements in China for 3,500 years before the Arrival of Domestic cats in 600-900 CE around the Tang Dynasty

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract The earliest cats in human settlements China were not domestic ( Felis catus ), but native leopard Prionailurus bengalensis ). To trace when and how arrived East Asia, we analyzed 22 feline bones from 14 sites across spanning 5,000 years. Nuclear mitochondrial genomes revealed that began occupying anthropogenic scenes around 5,400 years ago last appeared 150 CE. Following several centuries’ gap of archeological remains, the first known cat (706–883 CE) was identified Shaanxi during Tang Dynasty. Genomic analysis suggested a white or partially coat link to contemporaneous Kazakhstan, indicating likely dispersal route via Silk Road. two felids once independently occupied ancient environments followed divergent paths reached different destinations human-animal interactions.

Language: Английский

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The Prevalence of Corneal Disorders in Pugs Attending Primary Care Veterinary Practices in Australia

Animals, Journal Year: 2025, Volume and Issue: 15(4), P. 531 - 531

Published: Feb. 13, 2025

Pugs are highly predisposed to corneal disorders, such as brachycephalic ocular syndrome (BOS), due their disproportionate skull, reduced sensitivity and eyelid anomalies distichiasis, entropion lagophthalmos. The risk of disorders which cause significant suffering is substantial, prompting calls for international efforts reduce prevalence. While these debilitating conditions also likely be common in pugs Australia, prevalence factors have not been reported. anonymised electronic patient records (EPRs) 1318 attending 139 primary care veterinary clinics participating VetCompass Australia (VCA) 2017 were used investigate the ophthalmological pathologies associated demographic factors. diagnosed with overweight/obesity (prevalence: 20.2%, 95% confidence interval {CI}: 18.1-22.4) abnormalities (14.5%, CI: 12.6-16.3), particularly (12.4%, 12-15.7), other conditions. most prevalent ulcers (5.5%, 4.4-6.9), pigmentation (3.6%, 2.8-4.8) keratoconjunctivitis sicca (KCS) (3.3%, 2.5-4.5). all increased age (odds ratio 1.11, 1.07-1.15), pigmentation, KCS keratitis more older (a median 7.6 years or older), while entropion, neovascularisation ulcerative affected younger dogs 3 under). underlying BOS conformation defects, exophthalmos, lagophthalmos early signs damage should identified through detailed examinations during visits, removed from breeding population treated severity duration suffering.

Language: Английский

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Investigating the relationship between inbreeding and life expectancy in dogs: mongrels live longer than pure breeds

PeerJ, Journal Year: 2023, Volume and Issue: 11, P. e15718 - e15718

Published: July 19, 2023

This study aimed to investigate the establishment of relationship between inbreeding and life expectancy in dogs. A dataset

Language: Английский

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