EXO1's pan-cancer roles: diagnostic, prognostic, and immunological analyses through bioinformatics DOI Creative Commons
Zheng Liu,

Shu Huang,

Rui Luo

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 12, 2025

Cancer remains a leading cause of mortality worldwide, with human exonuclease 1 (EXO1) emerging as key player in DNA repair and damage response pathways, critical for genomic stability tumor evolution. The aim this study was to conduct comprehensive pan-cancer analysis elucidate the multifaceted roles EXO1 various malignancies. Leveraging public databases including TCGA, GTEx, HPA, cBioPortal, UALCAN, STRING, CancerSEA TISIDB database, we examined EXO1's expression, diagnostic potential, prognostic significance, mutational characteristics, functional roles, immunological effects across different cancer types. found be upregulated multiple cancers, significant potential indicated by high AUC values ROC analyses. Elevated expression correlated adverse prognosis several types, breast, lung, pancreatic cancers. Epigenetic alterations, methylation mRNA modifications, were also associated expression. Enrichment analyses identified EXO1-related genes involved recombination, replication, repair, GSEA implicating cell cycle regulation processing pathways. Importantly, immunogenomic revealed role modulating microenvironment, it is immune infiltration cytokine suggesting its involvement immunology regulation. These results implied that biomarker malignancies, therapeutic target immunomodulatory processes within microenvironment.

Language: Английский

EXO1's pan-cancer roles: diagnostic, prognostic, and immunological analyses through bioinformatics DOI Creative Commons
Zheng Liu,

Shu Huang,

Rui Luo

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 12, 2025

Cancer remains a leading cause of mortality worldwide, with human exonuclease 1 (EXO1) emerging as key player in DNA repair and damage response pathways, critical for genomic stability tumor evolution. The aim this study was to conduct comprehensive pan-cancer analysis elucidate the multifaceted roles EXO1 various malignancies. Leveraging public databases including TCGA, GTEx, HPA, cBioPortal, UALCAN, STRING, CancerSEA TISIDB database, we examined EXO1's expression, diagnostic potential, prognostic significance, mutational characteristics, functional roles, immunological effects across different cancer types. found be upregulated multiple cancers, significant potential indicated by high AUC values ROC analyses. Elevated expression correlated adverse prognosis several types, breast, lung, pancreatic cancers. Epigenetic alterations, methylation mRNA modifications, were also associated expression. Enrichment analyses identified EXO1-related genes involved recombination, replication, repair, GSEA implicating cell cycle regulation processing pathways. Importantly, immunogenomic revealed role modulating microenvironment, it is immune infiltration cytokine suggesting its involvement immunology regulation. These results implied that biomarker malignancies, therapeutic target immunomodulatory processes within microenvironment.

Language: Английский

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