Transcriptome sequencing reveals the expression profiles of lncRNAs and mRNAs in goat skin tissues with different types of wool coats
Abstract
The
diverse
coat
types
of
cashmere
goats
significantly
influence
yield,
yet
the
regulatory
mechanisms
mediated
by
non-coding
RNAs
(ncRNAs)
remain
poorly
characterized.
In
this
study,
we
collected
skin
tissues
from
two
distinct
(CHLC_ESA
and
CHSC_ESA)
Jinlan
Cashmere
Goat
for
transcriptome
sequencing
analysis.
Our
findings
revealed
130
differentially
expressed
(DE)
lncRNAs
341
DE
mRNAs
in
tissues.
GO
functional
enrichment
analysis
uncovered
some
crucial
terms
such
as
keratin
filament,
intermediate
cytokine
activity,
receptor
binding,
along
with
pivotal
lncRNAs:
TCONS_00050130
TCONS_00050142.
Furthermore,
KEGG
pathway
identified
several
important
pathways
including
Estrogen
signaling
pathway,
Amino
sugar
nucleotide
metabolism,
Adipocytokine
Cytokine-cytokine
interaction.
Lastly,
constructing
a
ceRNA
network
between
mRNAs,
multiple
axes
targeting
genes
like
EPPK1,
IRF4,
CCL20,
CXCR7.
These
mechanistic
insights
not
only
advance
our
understanding
ncRNA-mediated
hair
follicle
biology
but
also
provide
actionable
targets
precision
breeding
strategies
to
enhance
quality
yield
across
caprine
species.
Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский