The neuropeptidomes of the sea cucumbers Stichopus cf. horrens and Holothuria scabra

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 27, 2025

The Philippines is a renowned marine biodiversity hotspot, home to several sea cucumber species with unusual biological traits. Among these, Stichopus cf. horrens notable for its ability undergo rapid body wall liquefaction when stressed, coupled remarkable regenerative abilities. In contrast, Holothuria scabra has one of the most robust walls in cucumbers and thrives many regimes tropics. Despite their intriguing traits, neurobiology chemical diversity these remain underexplored. Neuropeptides are important components an animal's neurobiological toolkit that underlie various physiological behavioral processes. Thus, discovery neuropeptides crucial step understanding molecular underpinnings unique traits cucumbers. Leveraging throughput sensitivity tandem mass spectrometry, we obtained unbiased view endogenous peptidomes radial nerve cord tissues non-model species, H. S. horrens. this work, sequenced 60 mature peptides from were derived 22 precursor proteins, 43 originating 25 proteins nervous tissues. A total seven previously unannotated uncharacterized neuropeptide precursors identified, thereby expanding known animal repertoire. Furthermore, discovered consistent structural features based on type post-translational modifications while pushing forward potentially novel proteolytic processing sites during peptide maturation enriched flanking amino acid residues. Collectively, our results provide preliminary data expand echinoderm through discovery, paving way innovative solutions address global demand echinoderms.

Language: Английский

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Correlation between circadian and photoperiodic latitudinal clines in Drosophila littoralis

Open Biology, Journal Year: 2025, Volume and Issue: 15(3)

Published: March 1, 2025

Insects can survive harsh conditions, including Arctic winters, by entering a hormonally induced state of dormancy, known as diapause. Diapause is triggered environmental cues such shortening the photoperiod (lengthening night). The time entry into diapause depends on latitude insects' habitat, and this applies even within species: populations living at higher latitudes enter earlier in year than lower latitudes. A long-standing question biology whether internal circadian clock, which governs daily behaviour serves reference clock to measure night length, shows similar latitudinal adaptations. To address question, we examined onset various behavioural molecular parameters cosmopolitan fly, Drosophila littoralis, species distributed throughout Europe from Black Sea (41° N) regions (69° N). We found that all showed same correlation with critical length for induction. conclude has adapted may result observed differences

Language: Английский

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The Never Given 2022 Pittendrigh/Aschoff Lecture: The Clock Network in the Brain—Insights From Insects

Journal of Biological Rhythms, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

My journey into chronobiology began in 1977 with lectures and internships Wolfgang Engelmann Hans Erkert at the University of Tübingen Germany. At that time, only known animal clock gene was

Language: Английский

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The 2024 covers of the Journal of Comparative Physiology A

Journal of Comparative Physiology A, Journal Year: 2024, Volume and Issue: 210(6), P. 835 - 842

Published: Oct. 8, 2024

The covers of the 2024 issues Journal Comparative Physiology A are presented at full size and high resolution, together with stories behind them.

Language: Английский

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