Novel CT-derived markers for enhanced long-term risk stratification in the planning of TAVR for aortic stenosis

Journal of cardiovascular computed tomography, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Epicardial adipose tissue, cardiac damage, and mortality in patients undergoing TAVR for aortic stenosis

The International Journal of Cardiovascular Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 18, 2025

Computed tomography (CT)-derived Epicardial Adipose Tissue (EAT) is linked to cardiovascular disease outcomes. However, its role in patients undergoing Transcatheter Aortic Valve Replacement (TAVR) and the interplay with aortic stenosis (AS) cardiac damage (CD) remains unexplored. We aim investigate relationship between EAT characteristics, AS CD, all-cause mortality. retrospectively included consecutive who underwent CT-TAVR followed by TAVR. volume density were estimated using a deep-learning platform CD was assessed echocardiography. Patients classified according low/high density. All-cause mortality at 4 years compared Kaplan-Meier Cox regression analyses. A total of 666 (median age 81 [74-86] years; 54% female) included. After median follow-up 1.28 (IQR 0.53-2.57) years, 11.7% (n = 77) died. The (p 0.017) decreased, increased < 0.001) worsening CD. low (< 49cm3) high (≥-86 HU) had higher (log-rank p 0.02 0.01, respectively), even when adjusted for age, sex, clinical characteristics (HR 1.71, HR 1.73, 0.03, respectively). When added model, 1.67 0.03) stages 3 3.14, remained associated In TAVR, CT-derived volume, independently 4-year worse stage. Only

Language: Английский

Body composition of metabolically unhealthy normal-weight patients with aortic stenosis: a prospective cohort study

BMC Cardiovascular Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 23, 2024

The aim of this study was to evaluate the prognostic impact computed tomography (CT)-based body composition parameters in metabolically unhealthy normal-weight patients (MUHNW) with aortic stenosis (AS) undergoing transcatheter valve replacement (TAVR). This prospective cohort involved adults normal weight scheduled for TAVR. Patients were divided into two groups: healthy (MHNW) and MUHNW. primary outcome major adverse cardiovascular events (MACEs), secondary outcomes all-cause mortality prolonged hospital stay. Logistic regression used explore relationships between variables outcomes, Cox models applied examine effects different on patient prognosis. Incremental discriminative improvement (IDI) C-index determine influence hybrid predictive efficiency model. included 182 MHNW (n = 97) MUHNW 85). Over a median follow-up 0.8 years, multivariable logistic analysis revealed significant associations skeletal muscle index (SMind) (HR: 0.50, 95% CI: 0.29 – 0.84, p 0.01), subcutaneous adipose tissue (SATind) 0.63, 0.45 0.88, visceral (VATind) 1.34, 1.10 1.63, < 0.01) risk experiencing MACEs, whereas epicardial (EAT) not significantly associated MACEs model 1.10, 0.97 1.24, 0.14). For outcome, adjusted covariates, had an IDI 0.25 0.8, SMind 0.73, 0.62 0.87, SATind 0.78 0.97, VATind 1.25, 1.12–1.40, MACEs. 0.36 0.93, EAT showing protective effect against stay 0.93 0.99; 0.04). Body parameters, including, VATind, SMind, SATind, are predictors Additionally, shows These findings highlight potential importance comprehensive assessments stratification management AS patients.

Language: Английский