Design and Analysis of Surface Plasmon Resonance-Based Refractive Index Biosensor for Detection of Colorectal Cancer with Machine Learning Approach

Plasmonics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

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Factors associated with false fecal immunochemical test results in colorectal cancer screening

World Journal of Gastrointestinal Oncology, Journal Year: 2025, Volume and Issue: 17(4)

Published: March 24, 2025

Certain subgroups are at an increased risk of false fecal immunochemical test (FIT) results; however, related studies limited, and the available evidence is conflicting. To evaluate factors associated with false-positive false-negative FIT results. This retrospective study was based on database Tianjin Colorectal Cancer Screening Program from 2012 to 2020. A total 4129947 residents aged 40-74 years completed least one FIT. Of these, 24890 asymptomatic participants who underwent colonoscopy examinations lifestyle questionnaires were included in analysis. Multivariable logistic regression performed identify Among overall screening population, 88687 (2.15%) tested positive for The sensitivity, specificity, predictive value, negative value advanced neoplasms 58.2%, 44.8%, 9.7%, 91.3%, respectively. Older age, female sex, smoking, alcohol consumption, higher body mass index, hemorrhoids significantly odds lower Moreover, features high-grade dysplasia or villous adenoma presence cancer also results, while irregular exercise diverticulum results may be inaccurate certain subgroups. Our provide important further individualization strategies.

Language: Английский

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Differential findings in patients with proximal and distal advanced adenomas

Endoscopy, Journal Year: 2025, Volume and Issue: 57(S 02), P. S314 - S315

Published: March 1, 2025

Language: Английский

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RBM10 suppresses colorectal cancer invasion by regulating LncRNA SNHG17 alternative splicing

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 14, 2025

To explore the role of RBM10 in colorectal cancer (CRC) and regulatory mechanism CRC invasion through alternative splicing (AS) long non-coding RNA (lncRNA) SNHG17 by RBM10. Samples were collected from sixty cases their corresponding adjacent normal tissues. Immunohistochemistry Western blot performed to analyze expression A Transwell assay was conducted evaluate effect on HCT116 cells, a detect EMT-related proteins. Moreover, CLIP-seq RIP experiments interaction between SNHG17. The significantly decreased tissues cells compared Overexpression inhibited invasion, while knockdown had opposite effect. found interact with regulate its splice isoform balance. Specifically, variant SNHG17_2 regulated upregulated positively correlated invasion. inhibits regulating SNHG17, providing new research directions potential targets for treatment.

Language: Английский

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Dietary intake data for patients with and without colorectal cancer: A logistic lasso regression analysis

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 22, 2024

Colorectal cancer is a global health challenge with high morbidity and mortality, but its causative factors remain unclear. In recent years, associations between various dietary patterns colorectal have been identified, no studies examined the association macro- micronutrient intake cancer. This study analyzed using logistic least absolute shrinkage selection operator (LASSO). The data were derived from national 1999–2010 National Health Nutrition Examination Survey (NHANES) cycle. These further filtered to select those aged 50 years or older who self-reported having (n = 168) did not self-report 649). LASSO regression new statistical technique based on R software. this study, was used analyze variables which most relevant selected. included currently recognized risk for nutrients related intake. Age, sex, race, are recognised factors, still showed significant after shrinkage. For of micronutrients, only thiamine (beta 0.003) zinc 0.0007) positively associated results suggest that may be strongly However, statistically propensities validated by ex vivo experiments.

Language: Английский

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Population-based screening for colorectal cancer in Wuhan, China

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 29, 2024

Fecal DNA test has emerged as a non-invasive alternative for colorectal cancer (CRC) screening in average-risk population. However, there is currently insufficient evidence China to demonstrate the effectiveness of population-based CRC using fecal based test. Here, large-scale real-world study was implemented Wuhan, Hubei province, China. A total 98,683 subjects aged between 45 and 60 years were screened by (ColoTect ® ) which detected methylation status SDC2 , ADHFE1 PPP2R5C . Participants who tested positive advised receive diagnostic colonoscopy. 4449 (4.5%) test, 3200 (71.9%) underwent Among these, 2347 (73.3%) had abnormal colonoscopy findings, 1330 (56.7%) received pathological diagnosis. Detection rates advanced precancerous lesions 1.3% 2.3%, respectively. nonadvanced adenomas polyps 14.0% 21.6%, 28.0% all colonoscopies showed neoplasm but lack 6.1% other abnormalities such enteritis. In conclusion, preliminary suggested that tests promising yield screening. Clinical trial registration https://www.chictr.org.cn/showproj.html?proj=192838 identifier ChiCTR2300070520.

Language: Английский

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RBM10 regulates LncRNA SNHG17 alternative splicing to suppress colorectal cancer invasion mechanism research

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 10, 2024

Objective: To explore the role of RBM10 in colorectal cancer (CRC) and regulatory mechanism CRC invasion through alternative splicing (AS) long non-coding RNA (lncRNA) SNHG17 by RBM10. Methods: Samples were collected from sixty cases their corresponding adjacent normal tissues. Immunohistochemistry Western blot performed to analyze expression A Transwell assay was conducted evaluate effect on HCT116 cells, a detect EMT-related proteins. Moreover, CLIP-seq RIP experiments interaction between SNHG17. Results: The significantly decreased tissues cells compared Overexpression inhibited invasion, while knockdown had opposite effect. found interact with regulate its splice isoform balance. Specifically, variant SNHG17_2 regulated upregulated positively correlated invasion. Conclusion: inhibits regulating SNHG17, providing new research directions potential targets for treatment.

Language: Английский

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Importance of diet and intestinal microbiota in the prevention of colorectal cancer - colonoscopy early screening diagnosis

World Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 16(8), P. 3428 - 3435

Published: Aug. 7, 2024

Colorectal cancer is a term used to describe colon and rectal cancer, which the third most common type of cancer. A MEDLINE PubMed search resulted in inclusion manuscripts written last 10 years, using keywords relevant topic manuscript. By analyzing aim searched studies manuscripts, adequate articles were included that described stated problem. The frequency colorectal varies with climate, nutrition, many other factors, primarily endogenous, hereditary, intestinal microbiome, as well external such exposure individual stress, bad eating habits. Colon or general early stages disease, may not show symptoms are barely noticeable. will often develop until disease has progressed stage 2 beyond. Regular screening tests for especially colonoscopy, recommended part regular checkup people aged 50 years younger who at high risk due family history cancers. Diet colonoscopy an method play important role prevention

Language: Английский

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Tumor colorretal metacrônico de localização atípica: Relato de caso

LUMEN ET VIRTUS, Journal Year: 2024, Volume and Issue: 15(39), P. 2486 - 2496

Published: Aug. 22, 2024

O câncer colorretal e o de esôfago são neoplasias malignas distintas, mas compartilham fatores risco mecanismos carcinogênese. colorretal, originado no cólon ou reto, é caracterizado pelo crescimento descontrolado células epiteliais, tem alta incidência global, sendo terceiro mais comum a segunda principal causa morte por câncer. Em 2022, Brasil registrou 13.921 óbitos essa neoplasia, com maior prevalência em pessoas 50 anos, especialmente partir dos 70 anos. esôfago, responsável cerca 0,54 milhões mortes anuais oitava comum, manifesta-se como carcinomas escamosas adenocarcinomas está fortemente associado histórico familiar, tabagismo consumo álcool. Ambos os tipos envolvem disfunção celular resistência à apoptose, sexo masculino embora não haja uma relação direta entre eles.

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