Colchicine prevents perioperative myocardial injury in cardiac surgery by inhibiting the formation of neutrophil extracellular traps: evidence from rat models DOI Creative Commons

Hao-Dong Pan,

You-Ru Kong,

Li Xu

et al.

European Journal of Cardio-Thoracic Surgery, Journal Year: 2024, Volume and Issue: 66(4)

Published: Oct. 1, 2024

Abstract OBJECTIVES Colchicine, an anti-inflammatory agent, has been reported to improve myocardial infarction prognosis by inhibiting neutrophil extracellular traps (NETs) release. However, its role in cardiac surgery and the mechanisms behind NETs suppression remain unclear. This study aimed explore colchicine’s cardioprotective effects against perioperative injury surgery, focusing on inhibition as a novel therapeutic strategy. METHODS Male Sprague-Dawley rats were pre-treated with colchicine (0.1 mg/kg/day) or CI-amidine (10 for 7 days before undergoing cardiopulmonary bypass ischaemia/reperfusion injury. The model was created subjecting Under 4.0% sevoflurane anaesthesia, initiated cannulating tail artery right atrium, perfusion maintained 4 h. Immunofluorescence detected NETs, haematoxylin eosin staining assessed inflammatory cell. RESULTS We found treatment significantly reduced rats. Furthermore, we observed notable elevation of tissue animal models. Moreover, suppressing peptidylarginine deiminase markedly diminish Additionally, can mitigate release 4. CONCLUSIONS elevated during period surgery. Colchicine mitigated formation, being one mechanisms.

Language: Английский

Colchicine prevents perioperative myocardial injury in cardiac surgery by inhibiting the formation of neutrophil extracellular traps: evidence from rat models DOI Creative Commons

Hao-Dong Pan,

You-Ru Kong,

Li Xu

et al.

European Journal of Cardio-Thoracic Surgery, Journal Year: 2024, Volume and Issue: 66(4)

Published: Oct. 1, 2024

Abstract OBJECTIVES Colchicine, an anti-inflammatory agent, has been reported to improve myocardial infarction prognosis by inhibiting neutrophil extracellular traps (NETs) release. However, its role in cardiac surgery and the mechanisms behind NETs suppression remain unclear. This study aimed explore colchicine’s cardioprotective effects against perioperative injury surgery, focusing on inhibition as a novel therapeutic strategy. METHODS Male Sprague-Dawley rats were pre-treated with colchicine (0.1 mg/kg/day) or CI-amidine (10 for 7 days before undergoing cardiopulmonary bypass ischaemia/reperfusion injury. The model was created subjecting Under 4.0% sevoflurane anaesthesia, initiated cannulating tail artery right atrium, perfusion maintained 4 h. Immunofluorescence detected NETs, haematoxylin eosin staining assessed inflammatory cell. RESULTS We found treatment significantly reduced rats. Furthermore, we observed notable elevation of tissue animal models. Moreover, suppressing peptidylarginine deiminase markedly diminish Additionally, can mitigate release 4. CONCLUSIONS elevated during period surgery. Colchicine mitigated formation, being one mechanisms.

Language: Английский

Citations

0