Sex-Specific Associations of Cardiovascular Risk Factors with Subclinical Cardiac Remodeling: A Magnetic Resonance Imaging Study

Canadian Journal of Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Cardiovascular disease (CVD) is the leading cause of death in women, yet sex-specific risk factor influences remain understudied. Cardiac magnetic resonance imaging (CMR) detects early remodeling via left ventricular mass-to-volume ratio (LVMV), a validated concentricity marker. This study examines sex differences association CV factors, diet, and cardiac remodeling. We analyzed 622 age-matched adults (51% female, mean age 50.8 ± 9.5) from Courtois Signature Program. LVMV was defined as LV systolic mass divided by end-diastolic volume. Alcohol sugar intake self-rated on Likert scale. Mann-Whitney U regression analyses assessed associations between factors LVMV. Hypertension present 20.6% males 17.4% females; diabetes 9.8% 6.0%. Males had higher triglycerides, alcohol/sugar intake, (0.92 0.20 vs. 0.77 0.18 g/ml). correlated with both sexes (males: ß=0.099, p<0.001; females: ß=0.078, p<0.05), while triglycerides (ß=0.032, p<0.05) alcohol (H=19.41, p<0.0001) were male-specific predictors. In females, significantly associated (ß=0.102, ß=0.062, p<0.05). impact differently sex. males, linked to showed stronger associations. These results underscore need for tailored cardiovascular prevention strategies that account metabolic lifestyle factors.

Language: Английский

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Sex differences in clinical profile, left ventricular remodeling and cardiovascular outcomes among diabetic patients with heart failure and reduced ejection fraction: a cardiac-MRI-based study

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 22, 2024

Abstract Background Heart failure with reduced ejection fraction (HFrEF) is associated a high rate of mortality and morbidity. Evidence has shown that sex differences may be an important contributor to phenotypic heterogeneity in patients HFrEF. Although diabetes mellitus (DM) frequently coexists HFrEF results worse prognosis, there remains need identify sex-related the characteristics outcomes this population. In study, we aimed investigate between-sex clinical profile, left ventricular (LV) remodeling, cardiovascular risk factors concomitant DM. Methods A total 273 DM who underwent cardiac MRI were included study. Clinical characteristics, LV remodeling as assessed by MRI, compared between sexes. Results Women older, leaner prone have anemia hypoproteinemia but less likely ischemic etiology. Cardiac revealed despite similar LVEFs sexes, was more concentric impaired global systolic peak strain longitudinal circumferential components decreased likelihood late gadolinium enhancement presence women than men. During median follow-up time 34.6 months, exhibited better overall survival men did (log-rank P = 0.042). Multivariable Cox proportional hazards analysis indicated different for predicting hypertension [hazard ratio (HR) 2.05, 95% confidence interval (CI) 1.05 4.85, 0.041] (HR 2.27, CI 1.06 4.37, 0.039) serving independent determinants women, whereas etiology 1.96, 1.11 3.48, 0.021) atrial fibrillation 1.86, 1.02 3.41, 0.044) served Conclusions Among DM, displayed had did. Sex-based context should addressed practice.

Language: Английский

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Cardiovascular magnetic resonance imaging markers of ageing: a multi-centre, cross-sectional cohort study

European Heart Journal Open, Journal Year: 2025, Volume and Issue: 5(3)

Published: April 30, 2025

Cardiac ageing involves a series of anatomical and physiological changes contributing to decline in overall performance. magnetic resonance (CMR) provides comprehensive structural functional assessment for detecting age-related cardiovascular remodelling. We aimed develop fully automated CMR model predict heart age. This international, multi-centre, retrospective observational study enrolled 191 healthy individuals with normal body mass index (BMI), free metabolic, cardiovascular, respiratory disease as the derivation cohort. Left atrial (LA) end-systolic volume LA ejection fraction were selected final model. The was validated on 366 patients BMI >25 kg/m2 one or more comorbidities [hypertension, diabetes mellitus (DM), fibrillation (AF), obesity]. In [median age: 34 years, 105 (55%) female], CMR-derived age similar chronological [bias: 0.05%, 95% confidence interval (CI): 9.56-9.67%, P = 0.993]. validation cohort 53 157 (43%) 4.6 years higher than (95% CI: 1.6-7.6 0.003). resonance-derived significantly hypertension (P < 0.001), DM AF 0.001) age-matched controls. Moreover, obesity Class I 0.07), II 0.11), III 0.001). highlights time course during unhealthy ageing. propose simple equations that should help communicate subtle ClinicalTrials.gov: NCT05114785.

Language: Английский

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Age- and sex-specific physiological cardiac remodeling: the search for the Fountain of Youth

Clinical Research in Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: March 18, 2024

Graphical Abstract Figure: Concepts of cardiac aging. Abbreviations: E/e’, transmitral early velocity to diastolic mitral annular velocity; EF, ejection fraction; LV, left ventricular; LVEDD, ventricular end-diastolic diameter; M/V left, mass volume ratio.

Language: Английский

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Effect of Ageing Process on Diastolic Function of the Heart

Journal of Prevention Diagnosis and Management of Human Diseases, Journal Year: 2024, Volume and Issue: 45, P. 18 - 25

Published: Aug. 1, 2024

As people age, diastolic function deteriorates. (1). Aging is a significant risk factor for the emergence of structural and functional problems in heart (2). Diastolic dysfunction problem observed with age. Echocardiography used to investigate presence dysfunction, pathophysiologic factors affecting left ventricular atrial anatomy function. (3) Aim study: The objective this study impact ageing process on which assessed by echocardiography. Methods: our cross sectional study, cases were collected from Al-Najaf Center Cardiac Surgery Transcatheter Therapy/ Al-Sader Teaching Hospital. It included 50 patients aged 38-86 who underwent 2d echocardiography assess heart. Results: results obviously showed that steadily declines age (P value < 0.05). Conclusion: significantly

Language: Английский

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