Nutritional Strategies for Battling Obesity-Linked Liver Disease: the Role of Medical Nutritional Therapy in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 11, 2025

This narrative review explores the role of Medical Nutritional Therapy (MNT) in managing Metabolic-Associated Steatotic Liver Disease (MASLD), previously known as nonalcoholic fatty liver disease. It aims to examine effectiveness specific nutritional strategies preventing and treating this obesity-linked Emerging evidence underscores benefits Mediterranean diet, low-carbohydrate diets, intermittent fasting reducing fat, improving insulin sensitivity, mitigating inflammation. Supplementing with vitamin E, omega-3 acids, silymarin can potentially reduce fibrosis promote health. MNT is a key intervention for MASLD management, emphasizing dietary patterns, caloric restriction, nutraceutical supplementation. Integrating these lifestyle modifications, including regular physical activity, offers comprehensive approach metabolic outcomes patients MASLD. Further research needed refine personalize therapeutic interventions.

Language: Английский

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An overview of obesity‐related complications: The epidemiological evidence linking body weight and other markers of obesity to adverse health outcomes

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract Obesity is a highly prevalent chronic multisystem disease associated with shortened life expectancy due to number of adverse health outcomes. Epidemiological data link body weight and parameters central fat distribution an increasing risk for type 2 diabetes, hypertension, fatty liver diseases, cardiovascular diseases including myocardial infarction, heart failure, atrial fibrillation, stroke, obstructive sleep apnoea, osteoarthritis, mental disorders some types cancer. However, the individual develop cardiometabolic other obesity‐related cannot entirely be explained by increased mass. Rather than excess accumulation, dysfunction adipose tissue may represent mechanistic between obesity There are people living who seem protected against premature development diseases. On hand, normal typical upon predominantly visceral distribution. The mechanisms linking impaired function in include adipocyte hypertrophy, altered cellular composition, limited expandability safe subcutaneous stores, ectopic deposition depots, organs, hypoxia, variety stresses, inflammatory processes, release pro‐inflammatory, diabetogenic atherogenic signals. Genetic environmental factors might contribute either alone or via interaction intrinsic biological variation function. still many open questions regarding how causes whether these pathologies could reversed. Evidence‐based loss interventions using behaviour change, pharmacological surgical approaches have clarified beneficial effects realistic sustained on complications as hard This review focusses recent advances understanding epidemiological trends Plain Language Summary complex progressive characterized excessive that impair quality life. Worldwide, adults has more doubled since 1990. lead reduced expectancy, because it increases (e.g., high blood pressure, stroke), musculoskeletal respiratory depression certain not every person develops For better prevention treatment, important understand mass related It become clear explain higher complications. People can low developing Compared those abdominal region, average bigger cells, immune cells signals released from directly affect brain, liver, vasculature organs. Both inherited environment cause abnormalities through changes lower calorie intake, physical activity), medications surgery improve health, reduce

Language: Английский

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Beneficial Effects of the Ketogenic Diet on Nonalcoholic Fatty Liver Disease (NAFLD/MAFLD)

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(16), P. 4857 - 4857

Published: Aug. 17, 2024

The prevalence of nonalcoholic fatty liver disease (NAFLD) is likely to be approaching 38% the world's population. It predicted become worse and main cause morbidity mortality due hepatic pathologies. particularly worrying that NAFLD increasingly diagnosed in children closely related, among other conditions, insulin resistance metabolic syndrome. Against this background concern awareness patients with low; one study, almost 96% adult USA were not aware their disease. Thus, studies on therapeutic tools used treat are extremely important. One promising treatment a well-formulated ketogenic diet (KD). aim paper present review available publications current state knowledge effect KD NAFLD. This includes characteristics key factors (from point view regression), which exerts its effects, i.e., reduction body weight, elimination fructose monosaccharides, limitation total carbohydrate intake, anti-inflammatory ketosis state, or modulation gut microbiome metabolome. In context evidence for effectiveness regression NAFLD, also suggests important role taking responsibility one's own health through increasing self-monitoring self-education.

Language: Английский

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The relevance of intestinal barrier dysfunction, antimicrobial proteins and bacterial endotoxin in metabolic dysfunction‐associated steatotic liver disease

European Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 54(7)

Published: April 18, 2024

Abstract Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a leading cause of end‐stage associated with increased mortality and cardiovascular disease. Obesity diabetes are the most important risk factors MASLD. It well‐established that obesity‐associated insulin resistance leads to situation tissue lipotoxicity characterized by an accumulation excess fat in non‐fat tissues such as liver, promoting development MASLD, its progression into metabolic steatohepatitis. Methods Here, we aimed review impact disrupted intestinal permeability, antimicrobial proteins bacterial endotoxin Results Conclusion Recent studies demonstrated obesity‐ obesogenic diets‐associated alterations microbiota along disruption barrier integrity, alteration and, consequence, enhanced translocation bloodstream might contribute this pathological process through impacting metabolism inflammation.

Language: Английский

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Excess dietary sugar and its impact on periodontal inflammation: a narrative review

BDJ Open, Journal Year: 2024, Volume and Issue: 10(1)

Published: Oct. 9, 2024

Sugar is omnipresent in the current food environment and sugar consumption has drastically risen over past century. Extensive evidence highlights negative health consequences of consuming excess dietary sugars, leading World Health Organization (WHO) American Heart Association (AHA) to devise guidelines restrict intake. According WHO's Global Oral Status Report 2022, oral diseases severe periodontitis are a massive public problem, sugars modifiable risk factor.

Language: Английский

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Honokiol, a neolignan from Magnolia officinalis, attenuated fructose-induced hepatic fat accumulation by improving intestinal barrier function in mice

Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Fructose activates a stress response shared by methylglyoxal and hydrogen peroxide in Streptococcus mutans

mBio, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

ABSTRACT Fructose catabolism by Streptococcus mutans is initiated three phosphotransferase (PTS) transporters yielding fructose-1-phosphate (F-1-P) or fructose-6-phosphate. Deletion of one such F-1-P-generating PTS, fruI , was shown to reduce the cariogenicity S. in rats fed a high-sucrose diet. Moreover, recent study linked fructose metabolism reactive electrophile species methylglyoxal. Here, we conducted comparative transcriptomic analysis treated briefly with 50 mM fructose, glucose, 5 methylglyoxal, 0.5 hydrogen peroxide (H 2 O ). The results revealed striking overlap between and methylglyoxal transcriptomes, totaling 176 genes, 61 which were also shared H transcriptome. This core genes encompassed many same pathways affected exposure low pH zinc intoxication. Consistent these findings, negatively impacted metal homeostasis mutant deficient expulsion growth major oxidative stress regulator SpxA1. Importantly, lowered culture at faster pace, allowed better survival under acidic nutrient-depleted conditions, enhanced competitiveness against sanguinis although moderated level F-1-P might further boost some benefits. Conversely, several commensal streptococcal displayed greater sensitivity that may affect their persistence dental biofilm. In conclusion, integrated into regulates critical functions required for its ability induce dysbiosis oral cavity. IMPORTANCE common monosaccharide biosphere, yet overconsumption has been various health problems humans including insulin resistance, obesity, diabetes, non-alcoholic liver diseases, even cancer. These effects are large part attributable unique biochemical characteristics metabolic responses associated degradation fructose. Yet, an understanding on physiology bacteria implications human microbiome severely lacking. performed series analyses gene regulation pathogen exposing it other important agents. Further supported growth, persistence, competition assays, our findings activate set stress-related prove bacterium persist cause diseases both within without

Language: Английский

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Nutrition and Neuroinflammation: Are Middle-Aged Women in the Red Zone?

Nutrients, Journal Year: 2025, Volume and Issue: 17(10), P. 1607 - 1607

Published: May 8, 2025

Women exhibit unique vulnerabilities in health, especially regarding mental health and neurodegenerative diseases. Biological, hormonal, metabolic differences contribute to sex-specific risks that remain underrepresented clinical studies. Diseases such as major depressive disorder (MDD) Alzheimer’s disease (AD) are more prevalent women may be influenced by hormonal transitions, particularly during menopause. Chronic low-grade inflammation is emerging a shared mechanism underlying both conditions, this inflammatory state can worsened dietary habits. During menopause, mood sleep disturbances influence behavior, leading enhanced snacking consumption of high-glycemic comfort foods. Such foods, low nutritional value, promote weight gain elevated markers. Their combined (or not) with preexisting Western diet pattern—already linked inflammation—could reinforce systemic involving the gut–brain axis. Moreover, symptoms “per se” could act on well. Peripheral cross blood–brain barrier, sustaining disorders promoting changes. Finally, MDD AD associated conditions obesity diabetes, which occur frequently women. The review highlights how menopause-related changes mood, sleep, heighten susceptibility

Language: Английский

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Ernährung – Physiologie und Pathophysiologie

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 85 - 177

Published: Jan. 1, 2025

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Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues

Obesity Reviews, Journal Year: 2024, Volume and Issue: 25(8)

Published: May 14, 2024

Summary Obesity stands as a formidable global health challenge, predisposing individuals to plethora of chronic illnesses such cardiovascular disease, diabetes, and cancer. A confluence genetic polymorphisms, suboptimal dietary choices, sedentary lifestyles significantly contribute the elevated incidence obesity. This multifaceted issue profoundly disrupts homeostatic equilibrium at both organismal cellular levels, with marked alterations in gut permeability salient consequence. The intricate mechanisms underlying these have yet be fully elucidated. Still, evidence suggests that heightened inflammatory cytokine levels remodeling tight junction (TJ) proteins, particularly claudins, play pivotal role manifestation epithelial barrier dysfunction Strategic targeting proteins implicated pathways metabolites short‐chain fatty acids presents promising intervention for restoring functionality among Nonetheless, recognizing heterogeneity affected is paramount; personalized medical interventions or regimens tailored specific backgrounds allergy profiles may prove indispensable. comprehensive review delves into nexus obesity, remodeling, dysfunction, offering critical appraisal potential therapeutic interventions.

Language: Английский

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