Bee Pollen Phytochemicals and Nutrients as Unequaled Pool of Epigenetic Regulators: Implications for Age-Related Diseases
Rachid Kacemi,
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María G. Campos
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Foods,
Journal Year:
2025,
Volume and Issue:
14(3), P. 347 - 347
Published: Jan. 21, 2025
Bee
pollen
is
characterized
by
an
exceptional
diversity
and
abundance
of
micronutrients
bioactive
phytochemicals.
This
richness
remains
very
sparsely
investigated,
but
accumulating
evidence
strongly
supports
a
promising
future
for
bee
in
human
nutrition
medicine.
Epigenetic
regulation
among
the
most
compelling
biomedical
topics
that
remain
completely
untapped
derivative
research.
In
our
current
research,
we
identified
numerous
ubiquitous
compounds
are
consistently
present
this
matrix,
regardless
its
botanical
geographical
origins,
have
been
well
studied
documented
as
epigenetic
regulators
recent
years.
Given
relative
newness
both
research
studies
within
nutritional,
pharmaceutical,
medical
sciences,
review
aims
to
bridge
these
valuable
fields
advance
related
experimental
investigations.
To
best
knowledge,
first
work
has
aimed
comprehensively
investigate
modulatory
potential
compounds.
Our
findings
also
unveiled
several
intriguing
phenomena,
such
dual
effect
same
compound
depending
on
cellular
context
or
some
cross-generational
heritability
traits.
Although
whole
extract
still
lacking,
study
clearly
indicates
avenue
worth
further
We
hope
constitutes
foundational
cornerstone
investigations
Language: Английский
Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis
Immunity & Ageing,
Journal Year:
2025,
Volume and Issue:
22(1)
Published: Jan. 10, 2025
The
characteristics
of
ulcerative
colitis
(UC)
in
the
elderly
are
quite
different
from
young
population.
Mitochondrial
injury
is
a
key
mechanism
regulating
both
aging
and
inflammation.
This
study
aims
to
reveal
role
mitochondrial
damage
pathogenesis
adult-
elderly-onset
UC.
RNA-sequencing
colonic
mucosa
UC
patients
was
performed.
Mitochondria-related
differentially
expressive
genes
(mDEGs)
immune
cell
infiltration
analysis
were
identified
performed
tissues
patients.
Mice
aged
6–8
weeks
20–24
months
administered
2%
dextran
sodium
sulphate
(DSS)
for
7
days
induce
colitis.
morphological
changes
ATP
levels
evaluated
colons
mice.
Mechanistically,
we
explored
association
mDEG
with
reactive
oxygen
species
(ROS),
consumption
rates,
NLRP3/IL-1β
pathway
HCT116
line.
Thirty
mDEGs
between
UC,
which
related
primarily
respiratory
function
also
had
significant
correlation
infiltrates
cells.
Compared
mice,
DSS-induced
mice
exhibited
more
severe
inflammation,
damaged
structure
lower
tissues.
ALDH1L1
as
hub
DEG
through
protein–protein
interaction
networks
RNA-seq,
downregulated
or
versus
healthy
controls.
In
tumor
necrosis
factor-alpha-stimulated
cells,
ROS,
NLRP3
IL-1β
expression
increased
less
respiration
an
upregulated
trend
after
knocking
down
ALDH1L1.
There
differences
structure,
production
mitochondria-related
gene
have
potential
link
cytokine
pathways
microenvironment.
prominent
may
be
factor
inflammatory
response
poorer
outcome
1.
Aged
exhibit
disrupted
morphology,
2.
Elderly-onset
molecules
compared
adult-onset
3.
significantly
4.
regulates
respiration,
pathways.
Language: Английский
Prenatal exposure to PM2.5 constituents and newborn leukocyte telomere length in a prospective study: Windows of susceptibility and modification by maternal folic acid supplementation
Journal of Hazardous Materials,
Journal Year:
2025,
Volume and Issue:
494, P. 138747 - 138747
Published: May 26, 2025
Language: Английский
Micronutrient intake and telomere length: findings from the UK Biobank
Μarianna Spinou,
No information about this author
Androniki Naska,
No information about this author
Christopher P. Nelson
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et al.
European Journal of Nutrition,
Journal Year:
2024,
Volume and Issue:
63(8), P. 2871 - 2883
Published: Aug. 23, 2024
Language: Английский
Association analysis of MTHFR (rs1801133 and rs1801131) gene polymorphism towards the development of type 2 diabetes mellitus in Dali area population from Yunnan Province, China
Yongxin Liu,
No information about this author
Genyuan Pu,
No information about this author
Caiting Yang
No information about this author
et al.
PeerJ,
Journal Year:
2024,
Volume and Issue:
12, P. e18334 - e18334
Published: Oct. 24, 2024
Type
2
diabetes
mellitus
(T2DM)
is
a
common
complex
metabolic
disorder
that
exhibits
strong
genetic
predisposition.
5,10-methylenetetrahydrofolate
reductase
(MTHFR)
regulates
folate
metabolism,
which
has
been
proposed
to
be
associated
with
T2DM,
although
the
relationship
inconsistent
among
different
geographical
areas.
This
study
aimed
investigate
effects
of
MTHFR
C677T
(rs1801133)
and
A1298C
(rs1801131)
loci
polymorphisms
on
T2DM
susceptibility
in
population
Dali
area
Yunnan
Province,
China.
Language: Английский
Low folate biomarker concentrations are associated with increase the risk and severity of periodontitis in adults: A cross–sectional study based on the National Health and Nutrition Examination Survey 2009–2014
Nutrition Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
Language: Английский