A closer look at pathogenic amyloid-β in Alzheimer’s disease using cryo-electron microscopy: a narrative review DOI
Yang Gao, Sophia Schedin‐Weiss, Lars O. Tjernberg

et al.

Advanced technology in neuroscience ., Journal Year: 2024, Volume and Issue: 1(2), P. 177 - 187

Published: Nov. 27, 2024

Alzheimer’s disease is a progressive neurodegenerative disorder that affects millions of people worldwide. The identification amyloid-β in brains, together with the association mutations precursor protein pathology, basis amyloid cascade hypothesis, which suggests plays central role pathogenesis. Recent studies have further highlighted intraneuronal development. Moreover, success anti-amyloid-β immunotherapies supports emphasizing importance targeting specific conformations to achieve better therapeutic outcomes. In recent years, cryo-electron microscopy has become an invaluable tool for obtaining near-atomic resolution images assemblies, and multiple structures brain-derived fibrils been elucidated. this article, we review pathogenic according hypothesis explore relationship between accumulation development key pathological features disease—amyloid plaques neurofibrillary tangles. We also connect aggregates amyloid-β-targeting treatment highlight advances future research directions. application can provide molecular insights into structure, expected help uncover underlying mechanisms new strategies clearance aggregates.

Language: Английский

A closer look at pathogenic amyloid-β in Alzheimer’s disease using cryo-electron microscopy: a narrative review DOI
Yang Gao, Sophia Schedin‐Weiss, Lars O. Tjernberg

et al.

Advanced technology in neuroscience ., Journal Year: 2024, Volume and Issue: 1(2), P. 177 - 187

Published: Nov. 27, 2024

Alzheimer’s disease is a progressive neurodegenerative disorder that affects millions of people worldwide. The identification amyloid-β in brains, together with the association mutations precursor protein pathology, basis amyloid cascade hypothesis, which suggests plays central role pathogenesis. Recent studies have further highlighted intraneuronal development. Moreover, success anti-amyloid-β immunotherapies supports emphasizing importance targeting specific conformations to achieve better therapeutic outcomes. In recent years, cryo-electron microscopy has become an invaluable tool for obtaining near-atomic resolution images assemblies, and multiple structures brain-derived fibrils been elucidated. this article, we review pathogenic according hypothesis explore relationship between accumulation development key pathological features disease—amyloid plaques neurofibrillary tangles. We also connect aggregates amyloid-β-targeting treatment highlight advances future research directions. application can provide molecular insights into structure, expected help uncover underlying mechanisms new strategies clearance aggregates.

Language: Английский

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