Soluble tau aggregates decrease the threshold for thalamic oscillations and increase the excitability of thalamic neurons

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110455 - 110455

Published: April 1, 2025

Language: Английский

Pathological tau alters head direction signaling and induces spatial disorientation

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Summary Disorientation is an early symptom of dementia, suggesting impairments in neural circuits responsible for head direction signaling. The anterodorsal thalamic nucleus (ADn) exhibits and selective vulnerability to pathological misfolded forms tau (ptau), a major hallmark Alzheimer’s disease ageing. ADn contains high density (HD) cells; their disruption may contribute spatial disorientation. To test this, we virally expressed human the adult mice. HD-ptau mice were defined by ptau+ cells axon terminals postsynaptic target regions. Despite being able learn memory tasks, exhibited increased looping behavior during learning made greater number turns recall, consistent with Using vivo extracellular recordings, identified ptau-expressing found that from had reduced directionality altered burst firing. These data suggest ptau alters HD signaling, leading orientation.

Language: Английский

Pathological Tau Alters Head Direction Signaling and Induces Spatial Disorientation

Published: Jan. 1, 2024

Language: Английский