Human papillomavirus and its association with oral lichen planus DOI Open Access
V. A. Starshinina, Yu. N. Perlamutrov, Kira B. Olhovskaya

et al.

Russian Journal of Skin and Venereal Diseases, Journal Year: 2023, Volume and Issue: 26(6), P. 645 - 652

Published: Dec. 12, 2023

BACKGROUND: Oral lichen planus is a chronic disease with periods of exacerbations and remissions, requiring long-term symptomatic treatment observation. Dermatosis can occur or worsen in the presence different triggers, for example, due to persistence human papillomavirus. AIM: explore effect papillomavirus on characteristics oral planus. MATERIALS AND METHODS: 90 patients aged from 26 73 years (average age 55.61±1.00 years) were examined. Real-time polymerase chain reaction was used detect papillomavirus. The need caries, Green–Vermillion complex periodontal indices analysis state hygiene. RESULTS: Human DNA detected 53 (58.88%) cases. Patients this group 4 younger than other study participants; duration dermatosis 2 longer predominance atrophic/erythematous erosive/ulcerative forms. It noted that indexes caries significantly (p=0,007 p=0,030 respectively) higher compared without infection. CONCLUSION: found features identifying papillomavirus: early onset; severe predominantly destructive forms; high prevalence periodontitis.

Language: Английский

Lichen Planus: What is New in Diagnosis and Treatment? DOI
Burak Tekin, Fangyi Xie, Julia S. Lehman

et al.

American Journal of Clinical Dermatology, Journal Year: 2024, Volume and Issue: 25(5), P. 735 - 764

Published: July 9, 2024

Language: Английский

Citations

11
Vaccine-Induced Annular Atrophic Lichen Planus DOI Creative Commons
Curtis Perz, Jay Chittoor,

Liesel Grenier

et al.

Military Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Annular atrophic lichen planus (AALP) is a chronic subtype of that classically does not respond to treatment with topical steroids. An inflammatory reaction in the dermal infiltrate may play role development AALP, but exact pathogenesis remains unclear. We present case 54-year-old-female lesions on her trunk and extremities developed following vaccination. Her failed response warranted further workup for which was confirmed around 1 year after initiation. Although vaccine-induced common, it has been reported various cases. rare AALP vaccination then provide an in-depth discussion factors associated condition current response.

Language: Английский

Citations

0
Impact of COVID-19 on the prevalence of oral and maxillofacial disorders: A retrospective cohort study DOI Creative Commons
Bashar H. Abdullah, Omar Museedi, Noor Allawi

et al.

Science Progress, Journal Year: 2025, Volume and Issue: 108(1)

Published: Jan. 1, 2025

Objective The COVID-19 pandemic has impacted various health conditions. Emerging evidence suggests that may trigger or exacerbate oral and maxillofacial conditions, yet data from Iraq the broader Middle East remain limited. This retrospective cohort study, conducted at Laboratory of Oral Pathology, College Dentistry, University Baghdad, explores potential links between infection disorders. Methods was a study using Baghdad. Cases were divided into pre-COVID-19 post-COVID-19 periods. Chi-square tests assessed differences in pathologies incidence, while logistic regression analyzed associations with status corticosteroid use. Results Mucormycosis cases demonstrated significant increase 3 (pre-COVID-19) to 23 (post-COVID-19), 65.22% patients testing COVID-19-positive. A mucormycosis severity observed after (χ² = 14.24, p 0.0026). Logistic identified age (coefficient 0.8738) as having association severe mucormycosis, 0.1272) exerted lesser effect. Sjögren's syndrome increased 15 25 cases, model area under curve 0.8, indicating substantial ability distinguish symptom changes pre- vs. post-COVID-19. Conclusion findings suggest considerably incidence syndrome. Older positivity be key drivers whereas appeared symptoms. These results underscore importance vigilant monitoring targeted therapeutic strategies for managing conditions during viral pandemics.

Language: Английский

Citations

0
Risk of Oral Squamous Cell Carcinoma in One Hundred Patients with Oral Lichen Planus: A Follow-Up Study of Umberto I University Hospital of Rome DOI Open Access
Gianluca Tenore, Ahmed Mohsen, Federica Rocchetti

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(11), P. 3004 - 3004

Published: May 31, 2023

This study aims to retrospectively assess the potential risk of malignant transformation in patients with diagnosed oral lichen planus (OLP) between 2015 and 2022, evaluate influence different factors. The department's database medical records from 2022 were searched for a confirmed diagnosis OLP based on both clinical histological parameters. A total 100 (59 females 41 males) found mean age 64.03 years. In considered period, percentage was 1.6%, while squamous cell carcinoma (OSCC) 0.18%. statistically significant difference (p = 0.038), tobacco status 0.022), radiotherapy 0.041). analysis revealed presence ex-smokers (>20 pack-years), an odds ratio (OR) 10.0000 (95% confidence interval CI) 1.5793-63.3186); alcohol-drinker patients, OR 4.0519 CI 1.0182-16.1253); ex-smoker 17.6250 2.2464-138.2808); who had undergone radiotherapy, 6.3000 1.2661-31.3484). slightly higher than thought, results possible association age, alcohol status, history radiotherapy. An elevated observed heavy smoking (ex-smokers). Persuading patient quit consumption periodic follow-ups are recommended general, but particularly these

Language: Английский

Citations

10
Lichen planus triggered by COVID-19 vaccination: A case series DOI Creative Commons
Murali Narasimhan, R. Ramakrishnan,

Divya Sree Varri

et al.

Journal of Family Medicine and Primary Care, Journal Year: 2024, Volume and Issue: 13(1), P. 384 - 387

Published: Jan. 1, 2024

A BSTRACT Lichen planus, an autoimmune inflammatory condition, has been linked to medications, vaccinations, and infections. Several clinical studies have shown that majority of vaccines trigger a Th1 response, which raises the blood levels IL-2, TNF & IFN, may be development lichen planus. It recently documented happen with mRNA-based COVID-19 especially Pfizer/BioNTech vaccine. We present case series planus appeared after receiving COVISHIELD vaccine from Oxford-AstraZeneca. In order rule out any further potential triggers, like recent infections, prior drug use, smoking, dental treatments, etc., thorough history was collected in each instance. Skin biopsies were used confirm case’s diagnosis. nearly all cases, skin revealed typical dermatopathological features

Language: Английский

Citations

3
The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle “exposome” factors DOI Creative Commons

Olumayowa T. Adebiyi,

Dominique F. Galloway,

Michael S. Augustin

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 10, 2023

Pemphigus vulgaris (PV) is a potentially life-threatening blistering disorder characterized by autoantibodies directed against cell-cell adhesion molecules that serves as an excellent model to study human autoimmune development. Numerous studies have identified specific Human Leukocyte Antigen (HLA) genes, in particular DRB1*0402 and DQB1*0503, confer disease risk. Although HLA required, it not sufficient for the initiation of disease. As with all diseases, etio-pathogenesis PV complex, meaning multifactorial. Susceptibility polygenic, search non-HLA disease-linked genes continues. Moreover, twin across conditions indicate non-genetic environmental lifestyle factors, which can be collectively grouped under term “exposome”, are also major contributors The literature presents evidence potential role multiple triggers such medications, infections, stress, diet, immunizations, sleep influence etiology, pathophysiology, prognosis PV. However, clear understanding degree factors impact lacking. In this investigation, we comprehensively review elements listed above consider strength these factors. overall goals work provide greater insights into susceptibility, development course ultimately help better guide clinicians inform patients management

Language: Английский

Citations

8
Characteristics, comorbidities, and treatment practices of lichen planus in Northern Finland: A register‐based study among 619 subjects DOI Creative Commons

V M Anttonen,

Elia Pöykkö,

Eetu Kiviniemi

et al.

Health Science Reports, Journal Year: 2023, Volume and Issue: 6(6)

Published: June 1, 2023

Lichen planus (LP) is a common itching skin disease where lesions appear on the and mucous membranes. However, epidemiology of LP not yet sufficiently understood. The aim this study was to retrospectively map out characteristics, comorbidities treatments patients diagnosed with LP.

Language: Английский

Citations

4
Increased frequency of oral plasma cell mucositis/plasma cell gingivitis after the COVID-19 pandemic: a 23-year retrospective analysis and review of diagnostic challenges relating to this condition DOI

Sarah Fitzpatrick,

Saja A. Alramadhan, Mohammed N. Islam

et al.

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology, Journal Year: 2023, Volume and Issue: 137(2), P. 153 - 160

Published: Aug. 28, 2023

Language: Английский

Citations

4
Crossroads between Skin and Endocrine Glands: The Interplay of Lichen Planus with Thyroid Anomalies DOI Creative Commons
Andreea-Maria Radu, Mara Carşote, Claudiu Nistor

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 12(1), P. 77 - 77

Published: Dec. 28, 2023

In this narrative review, we aimed to overview the interplay between lichen planus (LP) and thyroid conditions (TCs) from a dual perspective (dermatologic endocrine), since current gap in understanding LP-TC connections is found so far topic still matter of debate. We searched PubMed Inception October 2023 by using key terms “lichen planus” “thyroid”, (alternatively, “endocrine” or “hormone”). included original clinical studies humans according three sections: LP TC dysfunction, autoimmunity, neoplasia. Six confirmed an association dysfunction (exclusively hypothyroidism) LP/OL (oral LP); note, only one study addressed cutaneous LP. The sample size LP/OLP groups varied 12–14 1500 individuals. Hypothyroidism prevalence OLP was 30–50%. A higher rate levothyroxine replacement identified among patients, at 10% versus 2.5% controls. highest OR (odd ratio) treated hypothyroidism amid 2.99 (p < 0.005). be associated with milder phenotype two studies. single cohort revealed similar non-LP. Non-confirmatory (only on OLP, not LP) five cohorts: controls, showed that subjects actually had lower controls (1% 4%). Positive autoimmunity eight studies; cohorts varied, for instance, 619 persons 76, 92, 105, 108, 192, 247, 585 patients (a total 1405) respectively; notably, largest control group 10,441 Four clusters approaches respect were found: analysis HT/ATD (Hashimoto’s thyroiditis/autoimmune diseases) prevalence; considerations over specific antibody levels; sex-related features females are more prone autoimmunity; associations (if any) aspects LP/OLP. HT statistically significantly higher, as follows: 19% 5%; 12% 6%; 20% 9.8%. addressing ATDs. One did confirm correlation OLP-associated elements (and severity) values against thyroid, another positive TPOAb (anti-thyroperoxidase antibodies) often erosive than non-erosive (68% 33%). Just reverse, (9% 15%). Five case-control issue prior diagnosed (no identified); them treatment (at 8.9%, 9.7%, 10.6%) conclusion, regard LP/OLP-TC, note several main practical points multidisciplinary practitioners: rather requires awareness; when it comes type mostly, should expected; female ATDs; potential ratio taking found, thus good collaboration endocrinology team mandatory; far, individuals have been risk nodules/cancer.

Language: Английский

Citations

4
Cutaneous adverse reactions associated with COVID-19 vaccines: Current evidence and potential immune mechanisms DOI Creative Commons
Po‐Chien Wu, Wan‐Chen Lin, Chuang‐Wei Wang

et al.

Clinical Immunology, Journal Year: 2024, Volume and Issue: 263, P. 110220 - 110220

Published: April 19, 2024

As the number of vaccinated individuals has increased, there have been increasing reports cutaneous hypersensitivity reactions. The main COVID-19 vaccines administered include messenger ribonucleic acid vaccines, non-replicating viral vector inactivated whole-virus and protein-based vaccines. These contain active components such as polyethylene glycol, polysorbate 80, aluminum, tromethamine, disodium edetate dihydrate. Recent advances in understanding coordination inflammatory responses by specific subsets lymphocytes led to a new classification based on immune response patterns. We categorize these into four patterns: T helper (Th)1-, Th2-, Th17/22-, Treg-polarized inflammation after stimulation Although association between vaccination adverse reactions remains controversial, occurrence rare dermatoses their short intervals suggest possible relationship. Despite potential reactions, administration is crucial ongoing battle against severe acute respiratory syndrome coronavirus 2.

Language: Английский

Citations

1