Targeting kallikrein proteases for dandruff therapy DOI

Hendra Wijaya Wong,

Ivan Kurniadi, Kris Herawan Timotius

et al.

Acta Dermatovenerologica Alpina Pannonica et Adriatica, Journal Year: 2024, Volume and Issue: 33(4)

Published: Jan. 1, 2024

Kallikrein proteases (KPs) are vital enzymes involved in the formation of dermatosomes and regulated by body's internal inhibitors. Maintaining a balance between KPs their inhibitors is essential for promoting healthy scalp. The scalp specifically contains two KPs: human kallikrein (hK) 5 hK7, which encoded respective genes. In addition, serine protease inhibitor Kazal-type (SPINK5) gene encodes lympho-epithelial Kazal-type‒related (LEKTI), effectively inhibits both hK5 hK7. normal desquamation process relies on availability activity along with regulation LEKTI. When LEKTI levels insufficient, it results abnormal characterized overactivity Consequently, KPs, particularly present promising targets novel treatments aimed at reducing flake associated dandruff. KP crucial components targeting these proteases. this review, literature dandruff, was analyzed to elucidate roles dandruff pathogenesis evaluate therapeutic potential inhibitor-based approaches managing condition.

Language: Английский

Potential Applications of Chitosan in Seborrheic Dermatitis and Other Skin Diseases: A Comprehensive Review DOI Creative Commons
Youting Liu,

Jianli Shang,

Yong Chen

et al.

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2025, Volume and Issue: Volume 18, P. 533 - 542

Published: March 1, 2025

This review article explores the potential applications of chitosan, a natural polysaccharide derived from crustacean shells, in treatment seborrheic dermatitis (SD) and other skin diseases. SD is common chronic inflammatory condition characterized by erythema, scaling, itching, an oily appearance, predominantly affecting areas rich sebaceous glands. Current treatments, including antifungal agents, corticosteroids, calcineurin inhibitors, offer symptomatic relief but have limitations long-term use due to side effects resistance issues. Chitosan exhibits excellent biocompatibility, biodegradability, broad-spectrum antibacterial properties, making it promising candidate for treatment. highlights chitosan's multifunctional properties such as antimicrobial, anti-inflammatory, sebum-regulating, barrier-enhancing effects, which are closely related pathogenesis SD. Additionally, summarizes chitosan conditions, wound healing, infectious diseases, atopic dermatitis, demonstrating its broad therapeutic potential. Through this comprehensive evaluation, aims provide theoretical foundation clinical research on support development new, safer, more effective options various conditions.

Language: Английский

Citations

1
Skin Microbiota: Mediator of Interactions Between Metabolic Disorders and Cutaneous Health and Disease DOI Creative Commons
Magdalini Kreouzi, Nikolaos Theodorakis, Maria Nikolaou

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 161 - 161

Published: Jan. 14, 2025

Metabolic disorders, including type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome, are systemic conditions that profoundly impact the skin microbiota, a dynamic community of bacteria, fungi, viruses, mites essential for cutaneous health. Dysbiosis caused by dysfunction contributes to barrier disruption, immune dysregulation, increased susceptibility inflammatory diseases, psoriasis, atopic dermatitis, acne. For instance, hyperglycemia in T2DM leads formation advanced glycation end products (AGEs), which bind receptor AGEs (RAGE) on keratinocytes cells, promoting oxidative stress inflammation while facilitating Staphylococcus aureus colonization dermatitis. Similarly, obesity-induced dysregulation sebaceous lipid composition increases saturated fatty acids, favoring pathogenic strains Cutibacterium acnes, produce metabolites exacerbate Advances metabolomics microbiome sequencing have unveiled critical biomarkers, such as short-chain acids microbial signatures, predictive therapeutic outcomes. example, elevated butyrate levels psoriasis been associated with reduced Th17-mediated inflammation, presence specific Lactobacillus has shown potential modulate tolerance Furthermore, machine learning models increasingly used integrate multi-omics data, enabling personalized interventions. Emerging therapies, probiotics postbiotics, aim restore diversity, phage therapy selectively targets bacteria like without disrupting beneficial flora. Clinical trials demonstrated significant reductions lesions improved quality-of-life metrics patients receiving these microbiota-targeted treatments. This review synthesizes current evidence bidirectional interplay between disorders highlighting implications future directions. By addressing microbiota-mediated pathways, precision strategies paving way patient outcomes dermatologic care.

Language: Английский

Citations

0
Seborrheic Dermatitis: Exploring the Complex Interplay with Malassezia DOI Open Access
Francesca Piacentini, Emanuela Camera, Anna Di Nardo

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2650 - 2650

Published: March 14, 2025

Seborrheic dermatitis (SD) is a chronic inflammatory skin condition often involving the sebaceous-rich areas, characterized by erythematous scaly lesions. It frequently observed in individuals with immune dysregulation, suggesting interplay between system and disease development. An altered environment leads to an exaggerated response activation of innate immunity, participation mast cells, γδ T NOD–LRR–pyrin-domain-containing protein 3 (NLRP3) inflammasome. This review aims assess complex relationship Malassezia pathogenesis SD. We will explore how impaired predisposes overgrowth infection. examine role adaptive particularly helper driving inflammation All actors involved, whether part or are responsible for release pro-inflammatory cytokines, which contribute progression disease. Therapeutic strategies aimed at modulation SD have been tested clinical trials evaluating efficacy immunomodulatory treatments management synthesizes insights from immunological studies present in-depth analysis mechanisms underpinning SD, thereby proposing targeted therapeutic its management.

Language: Английский

Citations

0
Ocular Manifestations in Seborrheic Dermatitis Epidemiology, Clinical Features, and Management: A Comprehensive Review DOI Open Access

Rasha M Alofi,

Lujain S Alrohaily,

Nada Nawaf Alharthi

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Seborrheic dermatitis (SD) often leads to ocular manifestations (OM) that are frequently overlooked. This study comprehensively explains the genesis of these issues, which involves a combination Malassezia overgrowth, changes in sebum production, and inflammatory responses body. The periocular region is rich sebaceous glands, allowing thrive, can lead an reaction spreads eye surface, causing disorders such as blepharitis, conjunctivitis, keratitis, surface diseases. Although epidemiological data limited, it well established involvement occurs approximately 10%-40% individuals with SD. Early detection treatment crucial prevent potential vision-threatening complications. A comprehensive diagnostic approach necessary, including clinical examination, slit-lamp biomicroscopy, tear film analysis, corneal imaging. Managing conditions requires multidisciplinary strategy involving collaboration between dermatologists ophthalmologists. should involve topical systemic medications address skin components. Patient education critical for improving adherence therapy, self-management, early identification problems. In future, will be essential investigate intricate interactions species host immunological processes. collective effort creating new biomarkers tools, investigating targeted immunomodulatory drugs novel lipid-based medicines treatments, conducting large-scale longitudinal studies understand patterns prognostic variables better. By raising awareness, encouraging across disciplines, advancing research, healthcare practitioners significantly improve patients' quality life SD OM.

Language: Английский

Citations

3
Combinatory Use of hLF(1-11), a Synthetic Peptide Derived from Human Lactoferrin, and Fluconazole/Amphotericin B against Malassezia furfur Reveals a Synergistic/Additive Antifungal Effect DOI Creative Commons

Carlo Brouwer,

Bart Theelen,

Youp van der Linden

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(8), P. 790 - 790

Published: Aug. 22, 2024

The increasing resistance of

Language: Английский

Citations

2
Seborrheic Dermatitis: From Microbiome and Skin Barrier Involvement to Emerging Approaches in Dermocosmetic Treatment DOI Creative Commons

Giulia Galizia,

Anna Belloni Fortina, Alessandra Semenzato

et al.

Cosmetics, Journal Year: 2024, Volume and Issue: 11(6), P. 208 - 208

Published: Nov. 28, 2024

Seborrheic dermatitis (SD) is a chronic inflammatory skin disease that primarily affects sebaceous-rich areas such as the scalp, face, and upper trunk. While precise etiology remains multifactorial, role of microbiome, particularly proliferation Malassezia species, alterations in barrier function are critical its pathogenesis. Disruption barrier, characterized by increased transepidermal water loss (TEWL) reduced production epidermal lipids, creates favorable environment for microbial overgrowth inflammation. Recent insights highlight interplay between impaired function, immune responses, microbiome perpetuating disease. Additionally, novel dermocosmetic approaches emerging target these underlying mechanisms, offering promising therapeutic avenues. This review provides comprehensive overview involvement dysfunction seborrheic discusses potential advanced treatments aimed at restoring homeostasis preventing recurrence.

Language: Английский

Citations

1
Unexplored fungal diversity on healthy and dandruff skin DOI
Pedro Nicolas Brito, Luciana Campos Paulino

Archives of Dermatological Research, Journal Year: 2024, Volume and Issue: 317(1)

Published: Dec. 4, 2024

Language: Английский

Citations

0
Targeting kallikrein proteases for dandruff therapy DOI

Hendra Wijaya Wong,

Ivan Kurniadi, Kris Herawan Timotius

et al.

Acta Dermatovenerologica Alpina Pannonica et Adriatica, Journal Year: 2024, Volume and Issue: 33(4)

Published: Jan. 1, 2024

Kallikrein proteases (KPs) are vital enzymes involved in the formation of dermatosomes and regulated by body's internal inhibitors. Maintaining a balance between KPs their inhibitors is essential for promoting healthy scalp. The scalp specifically contains two KPs: human kallikrein (hK) 5 hK7, which encoded respective genes. In addition, serine protease inhibitor Kazal-type (SPINK5) gene encodes lympho-epithelial Kazal-type‒related (LEKTI), effectively inhibits both hK5 hK7. normal desquamation process relies on availability activity along with regulation LEKTI. When LEKTI levels insufficient, it results abnormal characterized overactivity Consequently, KPs, particularly present promising targets novel treatments aimed at reducing flake associated dandruff. KP crucial components targeting these proteases. this review, literature dandruff, was analyzed to elucidate roles dandruff pathogenesis evaluate therapeutic potential inhibitor-based approaches managing condition.

Language: Английский

Citations

0