Prevalence of bacterial vaginosis among pregnant women attending antenatal care in low‐ and middle‐income countries between 2000 and 2020: A systematic review and meta‐analysis

Reproductive Female and Child Health, Journal Year: 2024, Volume and Issue: 3(2)

Published: June 1, 2024

Abstract Background Bacterial vaginosis increases risk of preterm birth and low birthweight, adverse pregnancy outcomes that disproportionately affect low‐ middle‐income countries (LMICs). Objectives We aimed to estimate the prevalence bacterial among pregnant women attending antenatal care in LMICs between 2000 2020. Search Strategy conducted a systematic review PubMed, Embase five regional databases. Selection Criteria included studies published 2020 which was reported care. Data Collection Analysis corrected point estimates applied random‐effects models generate pool estimates. carried out subgroup analyses by study year, country‐income level, HIV prevalence, sample size, diagnostic method, trimester pregnancy, presence symptoms at diagnosis bias. Main Results Of 1132 publications, 74 met inclusion criteria, contributing 80 data points from 46 661 women. Overall pooled mean across 15.7%. Regional ranged 25.1% sub‐Saharan Africa 7.4% Central Southern Asia. Prevalence 33.4% where ≥10%, 6.6% <10%. The who were symptomatic 24.2% versus 11.8% those without associated symptoms. Conclusions is high. World Health Organization guidelines recommend screening treatment for This recommendation should be extended include all have infection. Research needed characterise biological mechanisms lead investigate interventions may better interrupt these pathways.

Language: Английский

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A Controlled, Retrospective, Single-Center Study to Evaluate the Role of a Probiotic Mixture Administered during Pregnancy in Reducing Streptococcus Agalactiae Swab Positivity and the Frequency of Premature Rupture of Amniochorionic Membranes

Microorganisms, Journal Year: 2024, Volume and Issue: 12(10), P. 1979 - 1979

Published: Sept. 30, 2024

Intrapartum antibiotic prophylaxis, considered able to prevent streptococcal transmission from mother newborn and its severe negative consequences, leads microbiota dysbiosis, described as having a impact on well-being in both elements of the dyad.

Language: Английский

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Microbiological Profile of Vaginal Swabs from Infertile Women in the Cities of Ngaoundere and Garoua, Cameroon

Central African Journal of Public Health, Journal Year: 2024, Volume and Issue: 10(6), P. 242 - 256

Published: Nov. 20, 2024

Genital infections are a real public health problem in developed countries. They have serious consequences such as ectopic pregnancy (EP), chronic pelvic pain, premature delivery, miscarriage, cervical cancer and even infertility. The objective of this study was to determine the epidemiological microbiological profile genital among infertile women cities Ngaoundéré Garoua. This descriptive carried out Protestant regional hospitals, well military hospitals serving Garoua, over period five months, from August 2020 January 2021. Women reproductive age (15 45 years) who met inclusion criteria, gave their informed consent, had at least one consultation gynecology department aforementioned for infertility made up our population. Thus, included 100 women, or 50 per city. A pre-tested questionnaire employed get data subjects. Blood samples were taken chlamydia testing, cervical-vaginal analysis (PCV+ATB mycoplasma testing). gathered information. SphinxPlus. V5 program used analyze that collected. Ninety-six percent participated vaginal infection. women&apos;s modal range 26–35 years old, with mean 29. Of 54% housewives, 33% completed elementary; education, 55 monogamous marriages. At 65%, secondary most prevalent type. 5.15 average length Abortions accounted 41% patients&apos; histories, whereas 69%. When pH analyzed, majority (69%) &gt; 4.5. Chlamydia trachomatis (28.41%), Ureaplasma urealyticum (22.63%), Candidas albicans (20.58%), Gardnerella vaginalis (14.40%), Mycoplasma hominis (9.46%), spp (1.65%), Staphylococcus (1.64%), Trichomonas (0.82%), Neisseria gonorrhoeae (0.41%) analyses samples. etiological identification infectious tubal origin, which can be avoided early intervention, is greatly aided by microbiology.

Language: Английский

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Primary prevention with vaginal chlorhexidine before 16 weeks reduces the incidence of preterm birth: results of the Preterm Labor Prevention Using Vaginal Antiseptics study

AJOG Global Reports, Journal Year: 2023, Volume and Issue: 3(4), P. 100277 - 100277

Published: Oct. 16, 2023

: Preterm labor (PTB) is one of the leading causes perinatal death and currently considered a syndrome with many causes. One most important ascending infection, derived from bacterial vaginosis (BV). Chlorhexidine (CLX) has proven to be effective against BV biofilms without affecting gestation. We aimed evaluate effectiveness universal primary prevention strategy for PTB using intravaginal CLX applied before 16 weeks (preterm vaginal antiseptics, PLUVA study). performed prospective observational study two cohorts pregnant women that were assigned either by means (Cum Laude CLX®, digluconate 0,2%) (N=413), or no treatment following usual hospital protocol (N=704). Primary outcomes incidence spontaneous below 34 37 weeks, including inductions premature rupture membranes (PRM), any indication termination pregnancy. Both compared Mann-Whitney Fisher tests. Finally, multivariable analysis odds ratio (OR) was performed, adjusting clinical parameters, importance different determinants in prediction PTB. In pregnancies treated chlorhexidine PTB, induction PRM, pregnancy respectively at weeks: 0%, 0.24% 1.69, 2.90% 3.15%, while non-treated this 9%, 11%, 12% 23%, 35% 43%. According analysis, prior halved (OR 0.52, p<0.05). Universal reduces especially weeks.

Language: Английский

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Advanced Technologies for Studying Microbiome–Female Reproductive Tract Interactions: Organoids, Organoids-on-a-Chip, and Beyond

Seminars in Reproductive Medicine, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 1, 2023

Abstract The female reproductive tract (FRT) is home to diverse microbial communities that play a pivotal role in health and disorders such as infertility, endometriosis, cervical cancer. To understand the complex host–microbiota interactions within FRT, models authentically replicate FRT's environment, including interplay between microbiota, mucus layer, immune system, hormonal cycle, are key. Recent strides organoid microfluidic technologies propelling research this domain, offering insights into FRT–microbiota potential therapeutic avenues. This review delves current state of FRT microbe integration techniques, evaluating their merits challenges for specific objectives. Emphasis placed on innovative approaches applications, integrating organoids with microfluidics, using patient-derived biobanks, offers deeper mechanistic personalized strategies. Modeling various properties explored, from encompassing age-related epithelial features, oxygen levels, effects layers, responses, interactions, highlighting transform predict possible outcomes.

Language: Английский

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