Association of the Triglyceride–Glucose Index During the First Trimester of Pregnancy with Adverse Perinatal Outcomes DOI Creative Commons

Guillermo Gurza,

Nayeli Martínez-Cruz, Ileana Lizano-Jubert

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(9), P. 1129 - 1129

Published: April 29, 2025

Background/Objectives: Insulin resistance during pregnancy is a key factor underlying gestational diabetes mellitus (GDM) and other adverse perinatal outcomes (APOs). While traditional markers, such as HOMA-IR, are used to evaluate insulin resistance, they may be inaccessible in resource-limited settings. The triglyceride–glucose (TyG) index has emerged practical alternative. This study aimed assess whether or not TyG > 8.6 the first trimester of associated with an increased risk APOs, including GDM, preeclampsia, maternal neonatal complications. Methods: A prospective cohort was conducted involving 333 pregnant women Mexico City, divided into two groups: Group 1 (TyG 8.6, n = 153) 2 ≤ 180). Primary included (GDM), hypertensive disorders pregnancy, preterm birth, cesarean section, large-for-gestational-age (LGA) small-for-gestational-age (SGA) neonates. Logistic regression models were calculate adjusted relative (aRR) 95% confidence intervals (CIs), adjusting for age, pregestational weight, body mass (BMI). Results: Women had significantly higher weight BMI than those 8.6. demonstrated GDM (RR 2.05; CI: 1.23–3.41) preeclampsia 2.15; 1.10–4.21). After BMI, these associations remained significant: (aRR 1.87; 1.0–2.5) 2.18; 1.1–5.0). No significant found between elevated LGA, SGA, delivery. Conclusions: first-trimester highlighting its potential predictive marker outcomes. These findings underscore utility practical, cost-effective tool early stratification, particularly Further multi-center research needed validate results refine population-specific thresholds.

Language: Английский

Association of the Triglyceride–Glucose Index During the First Trimester of Pregnancy with Adverse Perinatal Outcomes DOI Creative Commons

Guillermo Gurza,

Nayeli Martínez-Cruz, Ileana Lizano-Jubert

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(9), P. 1129 - 1129

Published: April 29, 2025

Background/Objectives: Insulin resistance during pregnancy is a key factor underlying gestational diabetes mellitus (GDM) and other adverse perinatal outcomes (APOs). While traditional markers, such as HOMA-IR, are used to evaluate insulin resistance, they may be inaccessible in resource-limited settings. The triglyceride–glucose (TyG) index has emerged practical alternative. This study aimed assess whether or not TyG > 8.6 the first trimester of associated with an increased risk APOs, including GDM, preeclampsia, maternal neonatal complications. Methods: A prospective cohort was conducted involving 333 pregnant women Mexico City, divided into two groups: Group 1 (TyG 8.6, n = 153) 2 ≤ 180). Primary included (GDM), hypertensive disorders pregnancy, preterm birth, cesarean section, large-for-gestational-age (LGA) small-for-gestational-age (SGA) neonates. Logistic regression models were calculate adjusted relative (aRR) 95% confidence intervals (CIs), adjusting for age, pregestational weight, body mass (BMI). Results: Women had significantly higher weight BMI than those 8.6. demonstrated GDM (RR 2.05; CI: 1.23–3.41) preeclampsia 2.15; 1.10–4.21). After BMI, these associations remained significant: (aRR 1.87; 1.0–2.5) 2.18; 1.1–5.0). No significant found between elevated LGA, SGA, delivery. Conclusions: first-trimester highlighting its potential predictive marker outcomes. These findings underscore utility practical, cost-effective tool early stratification, particularly Further multi-center research needed validate results refine population-specific thresholds.

Language: Английский

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