Palmitoylethanolamide Supplementation for Human Health: A State-Of-The-Art Systematic Review of Randomized Controlled Trials in Patient Populations DOI Creative Commons
Riccardo Bortoletto,

Carla Comacchio,

Marco Garzitto

et al.

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: unknown, P. 100927 - 100927

Published: Dec. 1, 2024

Interest in preventative dietary interventions for human health has increasingly focused on the endocannabinoid (eCB)-like compound palmitoylethanolamide (PEA), a bioactive lipid mediator with anti-inflammatory, analgesic, and neuroprotective properties. This Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) 2020-compliant systematic review aimed at collecting comprehensively discussing all available data from Randomized Controlled Trials (RCTs) evaluating efficacy tolerability of PEA supplementation across illnesses patient populations. Overall, 48 eligible outputs 47 RCTs were extracted, covering neuropsychiatric (n = 15), neurological 17), somatic 13), visceral 11) disturbances, as well effects blood/plasma or other tissue biomarkers 10). The strongest evidence emerged exploring impact pain management measures general wellbeing, especially its ultramicronized/micronized cold-water dispersible formulations, showing good compared to controls. Also, alongside symptom improvement, demonstrated modulate early altered initial phases an illness contributing progression, suggesting disease-modifying potential. provided comprehensive overview therapeutic potential RCTs, highlighting versatility either monotherapy add-on treatment various clinical conditions.

Language: Английский

Parosmia: Pathophysiology and Management DOI Creative Commons

Xinni Xu,

Jerry Hadi Juratli, Basile N. Landis

et al.

Current Allergy and Asthma Reports, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 16, 2025

Language: Английский

Citations

0
Multisensory Rehabilitation in Older Adults to Improve Longevity and Wellness DOI
Arianna Di Stadio, Massimo Ralli, Diego Kaski

et al.

JAMA Otolaryngology–Head & Neck Surgery, Journal Year: 2024, Volume and Issue: 150(8), P. 748 - 748

Published: Aug. 1, 2024

To the Editor We read with great interest article of Vohra et al.1 The authors identified that a combination more than 1 sensory deficit may affect both physical function and mortality rate in older adults.

Language: Английский

Citations

1
The effectiveness of olfactory training for chronic olfactory disorder following COVID-19: a systematic review DOI Creative Commons
Natalia Treder-Rochna, Aleksandra Mańkowska,

Wiktoria Kujawa

et al.

Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Nov. 11, 2024

Chronic olfactory disorders are some of the most frequent post-COVID-19 presentations. Olfactory training (OT) is currently popular method used for treating post-viral dysfunction (PVOD). We evaluated effect on chronic patients infected with COVID-19.

Language: Английский

Citations

0
Palmitoylethanolamide Supplementation for Human Health: A State-Of-The-Art Systematic Review of Randomized Controlled Trials in Patient Populations DOI Creative Commons
Riccardo Bortoletto,

Carla Comacchio,

Marco Garzitto

et al.

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: unknown, P. 100927 - 100927

Published: Dec. 1, 2024

Interest in preventative dietary interventions for human health has increasingly focused on the endocannabinoid (eCB)-like compound palmitoylethanolamide (PEA), a bioactive lipid mediator with anti-inflammatory, analgesic, and neuroprotective properties. This Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) 2020-compliant systematic review aimed at collecting comprehensively discussing all available data from Randomized Controlled Trials (RCTs) evaluating efficacy tolerability of PEA supplementation across illnesses patient populations. Overall, 48 eligible outputs 47 RCTs were extracted, covering neuropsychiatric (n = 15), neurological 17), somatic 13), visceral 11) disturbances, as well effects blood/plasma or other tissue biomarkers 10). The strongest evidence emerged exploring impact pain management measures general wellbeing, especially its ultramicronized/micronized cold-water dispersible formulations, showing good compared to controls. Also, alongside symptom improvement, demonstrated modulate early altered initial phases an illness contributing progression, suggesting disease-modifying potential. provided comprehensive overview therapeutic potential RCTs, highlighting versatility either monotherapy add-on treatment various clinical conditions.

Language: Английский

Citations

0