Trombosi venosa cerebrale associata a otomastoidite con segni di ipertensione endocranica

Medico e Bambino, Journal Year: 2025, Volume and Issue: 44(01), P. 025 - 031

Published: Jan. 27, 2025

Venous thrombosis of the cerebral sinuses can complicate acute otitis media (AOM) due to close anatomical relationship between these structures. This condition presents a diagnostic challenge for clinicians, as it often manifests with nonspecific symptoms like headaches and carries risk quickly developing into intracranial hypertension. Here, we present case ten-year-old child history AOM who developed headache, later diagnosed otomastoiditis complicated by sigmoid sinus jugular-sigmoid junction. The patient required surgical intervention, along antibiotic anticoagulant therapy, leading full resolution thrombosis.

Language: Английский

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Streptococcus intermedius : an underestimated pathogen in brain infection?

Future Microbiology, Journal Year: 2024, Volume and Issue: 20(2), P. 163 - 177

Published: Nov. 18, 2024

Streptococcus intermedius is an oral commensal organism belonging to the anginosus group (SAG). S. causes periodontitis as well invasive, pyogenic infection of central nervous system, pleural space or liver. Compared with other SAG organisms, has a higher mortality predilection for intracranial infection, suggesting it likely possess virulence factors that mediate specific interactions host resulting in bacteria reaching brain. The mechanisms involved are not described. Intracranial suppuration (ICS) due can manifest abscess within brain parenchyma, collection pus (empyema) sub- extra-dural space. These infections necessitate neurosurgery and prolonged antibiotic treatment associated considerable burden morbidity mortality. incidence ICS increasing several settings, species accounting proportion cases. There paucity published literature regarding pathogenesis few genomes, hampering molecular epidemiological research. This perspective evaluates what known about clinical features explores hypothetical explanations why these may be increasing.

Language: Английский

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Exploring pathogen population density as a metric for understanding post-COVID infectious disease surges

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 3, 2024

After the easing of COVID-19 restrictions, peaks common infectious diseases surpassed pre-pandemic levels, raising questions about causes and ways to monitor these changes. A proposed measure, Pathogen Population Density (PPD) score, could help track shifts. PPD refers concentration agents within a population at given time location, serving as potential indicator infection levels in susceptible individuals level. It is likely that remains relatively stable specific community, an equilibrium forms between infections susceptibility. During pandemic, nonpharmaceutical interventions (NPIs) led reduction diseases, possibly lowering immunity decreasing score. Once NPIs were lifted, score increased sharply due larger pool individuals, causing more primary stronger recurrent infections, faster transmission, severe pathogenic outcomes individual Monitoring over predict when will occur. influenced by factors such public health strategies, vaccination programs, behavior high-risk individuals. As quantitative has serve valuable predictive monitoring tool, helping officials anticipate changes disease dynamics. be effective tool for managing future outbreaks or pandemics communication scientists understand emergence new peaks.

Language: Английский

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Increasing Incidence of Serious Head and Neck Infections Among US Children, 2018-2023

The Journal of Pediatrics, Journal Year: 2024, Volume and Issue: unknown, P. 114458 - 114458

Published: Dec. 1, 2024

Language: Английский

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