The Potential Role of the Microbiome in the Pathogenesis of Nasal Tumors: A Comprehensive Review DOI Creative Commons
Antonella Loperfido, Davide Rizzo, Bruno Fionda

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(11), P. 1808 - 1808

Published: Nov. 4, 2024

Cancers of the nose, and especially nose vestibule, represent a significant challenge for clinicians due to their rarity, intricate nature surrounding vital structures, nonspecific early symptoms, etiological factors that are not completely understood. Emerging research suggests alterations in nasal microbiome, also known as microbial dysbiosis, may contribute pathogenesis those malignancies through mechanisms involving chronic inflammation, immune modulation, cellular changes. The aims this paper review current literature covering microbiome’s role carcinogenesis, particularly context squamous cell carcinoma, explore how dysbiosis might foster pro-tumorigenic environment. It further discusses potential future directions therapeutic approaches.

Language: Английский

Intratumoral Fusobacterium nucleatum is associated with better cancer-specific survival in head and neck cancer patients DOI Creative Commons
José Guilherme Datorre, Mariana Bisarro dos Reis, Bruna Pereira Sorroche

et al.

Journal of Oral Microbiology, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 1, 2025

The oral microbiome, particularly Fusobacterium nucleatum (Fn), has been implicated in head and neck cancers (HNC), influencing local immunity Human Papillomavirus (HPV) status. Here, we evaluated the presence of Fn its association with HPV infection, TERT promoter (TERTp) mutations, patient outcomes. We analyzed 94 formalin-fixed paraffin-embedded (FFPE) tumor tissues from HNC patients previously for TERTp mutations. DNA was detected using droplet digital PCR (ddPCR), status determined via p16 immunohistochemistry pre-treatment samples. Associations between presence, clinicopathological features, HPV, mutation were assessed. Tumors primarily originated oropharynx (70.2%) cavity (29.8%). Tobacco alcohol use reported 87.2% 79.8% cases, respectively. present 59.6% higher prevalence oropharyngeal (62.1%) than (53.6%) tumors. No significant associations found TERTp, or However, positivity showed significantly improved cancer-specific survival (61.5% vs. 39.1%, p = 0.013), similar to HPV-positive (72.7% 42.7%, 0.014). correlates longer survival, highlighting potential as a prognostic marker.

Language: Английский

Citations

0
The Potential Role of the Microbiome in the Pathogenesis of Nasal Tumors: A Comprehensive Review DOI Creative Commons
Antonella Loperfido, Davide Rizzo, Bruno Fionda

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(11), P. 1808 - 1808

Published: Nov. 4, 2024

Cancers of the nose, and especially nose vestibule, represent a significant challenge for clinicians due to their rarity, intricate nature surrounding vital structures, nonspecific early symptoms, etiological factors that are not completely understood. Emerging research suggests alterations in nasal microbiome, also known as microbial dysbiosis, may contribute pathogenesis those malignancies through mechanisms involving chronic inflammation, immune modulation, cellular changes. The aims this paper review current literature covering microbiome’s role carcinogenesis, particularly context squamous cell carcinoma, explore how dysbiosis might foster pro-tumorigenic environment. It further discusses potential future directions therapeutic approaches.

Language: Английский

Citations

1