Arketamine: a scoping review of its use in humans DOI
Gustavo C. Leal,

Isabel Lima-Araújo,

David G. Roiter

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Language: Английский

Ketamine and its two enantiomers in anesthesiology and psychiatry: A historical review and future directions DOI Creative Commons
Kenji Hashimoto, Mingming Zhao, Tingting Zhu

et al.

Journal of Anesthesia and Translational Medicine, Journal Year: 2024, Volume and Issue: 3(3), P. 65 - 75

Published: July 11, 2024

Ketamine, a dissociative anesthetic, is widely utilized in both human and veterinary anesthesia. Its (S)-enantiomer, esketamine, similarly employed for anesthesia analgesia. The anesthetic effects of ketamine esketamine arise from their antagonism the N-methyl-D-aspartate receptor (NMDAR). In field psychiatry, rapid-acting antidepressant properties severe depression have generated significant interest, resulting its increased off-label usage United States (U.S.). 2019, nasal spray received approval use U.S. Europe. However, concerns emerged regarding potential adverse effects, including long-term efficacy, addiction risks, suicide risk clinical settings. contrast, arketamine, (R)-enantiomer ketamine, exhibits superior longer-lasting rodent models depression, with fewer side compared to esketamine. Nevertheless, research on efficacy safety arketamine patients remains limited. This article provides concise exploration historical two enantiomers while also delving into future directions application these fields.

Language: Английский

Citations

11
Repeated administration of esketamine ameliorates mechanical allodynia in mice with chemotherapy-induced peripheral neuropathy: A role of gut microbiota and metabolites DOI

Wei-Wei Luan,

Hanwen Gu,

Di Qiu

et al.

Neurochemistry International, Journal Year: 2025, Volume and Issue: 185, P. 105961 - 105961

Published: March 5, 2025

Language: Английский

Citations

0
Beneficial and adverse effects of ketamine and its enantiomers, and the underlying mechanisms of ECT and rTMS efficacy DOI Creative Commons
Kenji Hashimoto

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: 274(4), P. 755 - 757

Published: April 12, 2024

Language: Английский

Citations

0
Ketamine-induced altered states of consciousness: a systematic review of implications for therapeutic outcomes in psychiatric practices DOI

Kaike Thiê da Costa Gonçalves,

Vagner Deuel de Oliveira Tavares,

Maria Luiza de Morais Barros

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Language: Английский

Citations

0
Arketamine: a scoping review of its use in humans DOI
Gustavo C. Leal,

Isabel Lima-Araújo,

David G. Roiter

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Language: Английский

Citations

0