Antidepressant response time across intermittent theta burst stimulation regimens and efficacy indicators in adolescents depression: a secondary analysis from a randomized controlled trial DOI Creative Commons
Min Zhang, Weicheng Li, Zhibo Hu

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 18, 2024

Accelerated intermittent theta burst stimulation (aiTBS), which involves the administration of multiple daily sessions iTBS, represents a novel regimen repetitive transcranial magnetic stimulation. Studies have suggested that aiTBS may facilitate fast response among patients with major depressive disorders. However, whether can accelerate antidepressant in adolescents suffering from depression is still unclear. Additionally, potential indicators associated this population are understudied. Ninety were recruited and randomly assigned to (two 600-pulse iTBS spaced for 10 min, N = 31), (one session, 29), or sham (N 30) two treatment weeks. Kaplan–Meier analysis was used estimate mean time three groups. The covariance logistic regression applied identify response. 7.45 weeks (95% CI: 6.19–8.72) group, 5.62 4.09–7.16) 5.07 3.56–6.58) respectively. log rank test revealed no significant difference groups (χ2 4.156, p 0.125). For response, there also interactions between regimens baseline characteristics. Notably, participants higher motor threshold worse global function at likely be early final respectively, while those who experiencing child-parent separation both In addition, younger more experience recurrence during follow-up. did not demonstrate an advantage terms some pretreatment characteristics might serve as This relatively simple application based on seems cost-effective method develop sustain it. secondary primary RCT, officially registered Chinese Clinical Trial Registry 19/1/2021 number ChiCTR2100042346. https://www.chictr.org.cn/bin/project/edit?pid=66118 .

Language: Английский

Antidepressant response time across intermittent theta burst stimulation regimens and efficacy indicators in adolescents depression: a secondary analysis from a randomized controlled trial DOI Creative Commons
Min Zhang, Weicheng Li, Zhibo Hu

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 18, 2024

Accelerated intermittent theta burst stimulation (aiTBS), which involves the administration of multiple daily sessions iTBS, represents a novel regimen repetitive transcranial magnetic stimulation. Studies have suggested that aiTBS may facilitate fast response among patients with major depressive disorders. However, whether can accelerate antidepressant in adolescents suffering from depression is still unclear. Additionally, potential indicators associated this population are understudied. Ninety were recruited and randomly assigned to (two 600-pulse iTBS spaced for 10 min, N = 31), (one session, 29), or sham (N 30) two treatment weeks. Kaplan–Meier analysis was used estimate mean time three groups. The covariance logistic regression applied identify response. 7.45 weeks (95% CI: 6.19–8.72) group, 5.62 4.09–7.16) 5.07 3.56–6.58) respectively. log rank test revealed no significant difference groups (χ2 4.156, p 0.125). For response, there also interactions between regimens baseline characteristics. Notably, participants higher motor threshold worse global function at likely be early final respectively, while those who experiencing child-parent separation both In addition, younger more experience recurrence during follow-up. did not demonstrate an advantage terms some pretreatment characteristics might serve as This relatively simple application based on seems cost-effective method develop sustain it. secondary primary RCT, officially registered Chinese Clinical Trial Registry 19/1/2021 number ChiCTR2100042346. https://www.chictr.org.cn/bin/project/edit?pid=66118 .

Language: Английский

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