Serum Tau Species in Progressive Supranuclear Palsy: A Pilot Study DOI Creative Commons
Costanza Maria Cristiani, Luana Scaramuzzino, Elvira Immacolata Parrotta

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(23), P. 2746 - 2746

Published: Dec. 5, 2024

Progressive Supranuclear Palsy (PSP) is a tauopathy showing marked symptoms overlap with Parkinson's Disease (PD). PSP pathology suggests that tau protein might represent valuable biomarker to distinguish between the two diseases. Here, we investigated presence and diagnostic value of six different species (total tau, 4R-tau isoform, aggregates, p-tau202, p-tau231 p-tau396) in serum from 13 PD patients 12 healthy controls (HCs).

Language: Английский

Molecular insights into Parkinson's disease and type 2 diabetes mellitus: Metformin's role and genetic pathways explored DOI

Tingting Liu,

Haojie Wu,

Jianshe Wei

et al.

Experimental Neurology, Journal Year: 2025, Volume and Issue: 385, P. 115137 - 115137

Published: Jan. 10, 2025

Language: Английский

Citations

0
From Cell Architecture to Mitochondrial Signaling: Role of Intermediate Filaments in Health, Aging, and Disease DOI Open Access
Emanuele Marzetti, Rosa Di Lorenzo, Riccardo Calvani

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1100 - 1100

Published: Jan. 27, 2025

The coordination of cytoskeletal proteins shapes cell architectures and functions. Age-related changes in cellular mechanical properties have been linked to decreased tissue dysfunction. Studies also found a relationship between mitochondrial function the cytoskeleton. Cytoskeleton inhibitors impact quality function, including motility morphology, membrane potential, respiration. regulatory cytoskeleton on functions are involved pathogenesis several diseases. Disassembly axon’s release neurofilament fragments documented during neurodegeneration. However, these can be related impairments, spanning from reduced altered bioenergetics. Herein, we discuss recent research highlighting some pathophysiological roles disassembly aging, neurodegeneration, neuromuscular diseases, with focus studies that explored intermediate filaments signaling as relevant contributors health disease.

Language: Английский

Citations

0
Tau levels in platelets isolated from Huntington’s disease patients serve as a biomarker of disease severity DOI Creative Commons
Melanie Alpaugh, Juan Lantero‐Rodriguez, Andréa Lessa Benedet

et al.

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(3)

Published: March 1, 2025

Tau is a microtubule protein that known to be hyperphosphorylated and aggregate in several chronic neurodegenerative disorders. In many cases, particular Alzheimer's disease, the degree of tau pathology has been demonstrated correlate with cognitive deficits and/or decline. Huntington's disease (HD), dominantly inherited disorder, both impairments abnormal expression have reported occur, along accumulation mutant huntingtin protein. this respect, shown present cerebrospinal fluid individuals HD increase progression. However, how relates changes found periphery largely unknown. study, we collected blood samples from patients isolated multiple components including plasma, platelets, peripheral mononuclear cells measure their levels subsequently these stage. Our results suggest amount tau, particularly N-terminal (NTA-tau) total (t-tau), elevated all assayed quantity within specifically, strongly correlated severity.

Language: Английский

Citations

0
Cerebrospinal fluid and blood neurofilament light chain in Parkinson's disease and atypical parkinsonian syndromes: a systematic review and Bayesian network meta-analysis DOI

Wenyi Kou,

Siming Li, Rui Yan

et al.

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(4)

Published: April 1, 2025

Language: Английский

Citations

0
α-Synuclein seeding amplification assays for diagnosing synucleinopathies: an innovative tool in clinical implementation DOI Creative Commons
Yaoyun Kuang, Hengxu Mao, Xiaoyun Huang

et al.

Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)

Published: Nov. 21, 2024

Abstract The spectrum of synucleinopathies, including Parkinson’s disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), is characterized by α-synuclein (αSyn) pathology, which serves as the definitive diagnostic marker. However, current methods primarily rely on motor symptoms that manifest years after initial neuropathological changes, thereby delaying potential treatment. symptomatic overlap between PD MSA further complicates diagnosis, highlighting need for precise differential these overlapping neurodegenerative diseases. αSyn misfolding aggregation occur before clinical appear, suggesting detection pathological could enable early molecular diagnosis synucleinopathies. Recent advances in seed amplification assay (SAA) offer a tool detecting diseases identifying fluid tissue samples, even at preclinical stages. Extensive research has validated effectiveness reproducibility SAAs diagnosing ongoing efforts focusing optimizing conditions more accessible samples specific species to differentiate various This review offers thorough overview SAA technology, exploring its applications addressing challenges, outlining future directions use.

Language: Английский

Citations

2
Serum Tau Species in Progressive Supranuclear Palsy: A Pilot Study DOI Creative Commons
Costanza Maria Cristiani, Luana Scaramuzzino, Elvira Immacolata Parrotta

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(23), P. 2746 - 2746

Published: Dec. 5, 2024

Progressive Supranuclear Palsy (PSP) is a tauopathy showing marked symptoms overlap with Parkinson's Disease (PD). PSP pathology suggests that tau protein might represent valuable biomarker to distinguish between the two diseases. Here, we investigated presence and diagnostic value of six different species (total tau, 4R-tau isoform, aggregates, p-tau202, p-tau231 p-tau396) in serum from 13 PD patients 12 healthy controls (HCs).

Language: Английский

Citations

1