A preliminary clinical study related to vestibular migraine and cognitive dysfunction DOI Creative Commons
Tingting Sun,

Yake Lin,

Yanan Huang

et al.

Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Dec. 23, 2024

Background and purpose Vestibular migraine (VM) is a common clinical disorder with genetic predisposition characterized by recurrent episodes of dizziness/vertigo. Patients often complain the presence cognitive dysfunction manifestations such as memory loss, which causes great distress in daily life. In this study, we will explore characteristics possible risk factors VM-related observing function vestibular status VM patients, laying foundation for further exploration mechanisms dysfunction. Methods This study included 61 patients 30 healthy individuals matched age, gender, education level. All subjects underwent Addenbrooke’s Cognitive Examination-Revised (ACE-R), Dizziness Handicap Inventory (DHI), Hospital Anxiety Depression Scale (HADS), Patient Health Questionnaire-9 (PHQ-9), Generalized Disorder-7 (GAD-7) at first time enrollment. Based on ACE-R scores, group was divided into (VM-CogD) (ACE-R < 86) without (VM-NoCogD) ≥ 86). The VM-CogD categorized based DHI scores mild, moderate, severe dizziness/vertigo subgroups (DHI ≤ 60 > severe). head-shaking test, head-impulse test skew, Romberg Unterberger videonystagmography, caloric to evaluate their including semicircular canals, vestibulo-ocular reflex pathway, vestibulo-spinal pathway. Differential analysis, correlation ROC curve analysis were used analyze influencing above indicators patients. It considered that p -value 0.05 statistically significant, | r| 0.3 indicated good correlation. Results There no significant differences between control (HC) sex, age total score [82 (68.5, 87)], score, memory, verbal fluency, language, visuospatial significantly lower than those HC ( 0.05) percentage horizontal canal (82.0%), ocular motor (49.2%), positive (27.9%), (37.7%), Romberg’s sign (60.7%), Unterberger’s (60.7%) higher 0.05). Comparing VM-NoCogD 86), Canal Paresis (CP) value, years education, duration disease group, CP value negatively correlated r = 0.571, 0.000), 0.526, fluency 0.345, 0.024), language 0.524, 0.340, 0.026) scores. Age functioning 0.384, 0.011), positively 0.504, 0.001) 0.455, 0.002) When cutoff values 25.5, 33, 15.5, 6.5, accuracy predicting highest. DHI, DHI-P, DHI-E, DHI-F, HADS, PHQ-9, GAD-7 presenting moderate dizziness/vertigo, 0.539, 0.008), DHI-F 0.450, 0.031) part 0.415, 0.049) HADS-D 0.008). Conclusion (1) exhibit multifaceted varying degrees dysfunction, affected illness, function; (2) functional disorder, disturbance, conjunction anxiety depression, may participate occurrence development VM.

Language: Английский

Recurrence Rates and Risk Factors for Benign Paroxysmal Positional Vertigo: Insights from a Large Single-Institution Epidemiological Study DOI Open Access

Wathanya Jongwarothai,

Somchai Srirompotong,

Patorn Piromchai

et al.

Biomedical & Pharmacology Journal, Journal Year: 2025, Volume and Issue: 18(1), P. 879 - 885

Published: March 31, 2025

This study aimed to assess the recurrence rate of benign paroxysmal positional vertigo (BPPV) and identify risk factors for its at a major university hospital, which functions as regional referral center. included patients diagnosed with BPPV who received treatment Srinagarind Hospital, Khon Kaen University, Thailand between January 1, 2020, 2022. evaluated rate, associated in Thailand. A total 376 met inclusion criteria, majority being female (75.3%). The mean age was 58.09 ± 13.10 years. most commonly affected site posterior semicircular canal. Recurrence observed 33 (8.8%), highest (30.3%) occurring within first 6 months. Risk factor analysis showed that older adults were 2.91 times more likely experience year compared younger (95% CI: 1.12–7.59, P = 0.029). Further revealed experiencing 5 be than 1.04–24.03, 0.045). Gender, along comorbid conditions like diabetes, hypertension, history head trauma, not found significant recurrence.

Language: Английский

Citations

0
Orexin Receptor Antagonists for the Prevention and Treatment of Alzheimer’s Disease and Associated Sleep Disorders DOI Creative Commons
Matteo Carpi, Nicola Biagio Mercuri, Claudio Liguori

et al.

Drugs, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Orexins/hypocretins are neuropeptides produced by the hypothalamic neurons, binding two G-protein coupled receptors (orexin 1 and orexin 2 receptors) playing a critical role in regulating arousal, wakefulness, various physiological functions. Given high prevalence of sleep disturbances Alzheimer's disease (AD) their reported involvement AD pathophysiology, system is hypothesized to contribute pathogenesis. Specifically, recent evidence suggests that orexin's influence may extend beyond regulation, potentially affecting amyloid-β tau pathologies. Dual receptor antagonists (DORAs), namely suvorexant, lemborexant, daridorexant, demonstrated efficacy treating chronic insomnia disorder across diverse clinical populations. Considering stabilizing effects on parameters emerging possible neuroprotective role, these agents represent promising strategy for management. This leading article reviews potential use AD, particularly focusing effect modulating disease-associated outcomes. Overall, studies support DORAs enhance quality patients with comorbid circadian sleep-wake rhythm disorders. Preliminary results also suggest compounds might pathology, progression. Conversely, research selective currently limited. Further investigation needed explore antagonism not only as symptomatic treatment disturbances, but its broader implications modifying neurodegeneration, emphasizing mechanisms action long-term

Language: Английский

Citations

1
Endovascular thrombectomy with or without intravenous alteplase in large-core ischemic stroke: a systematic review and meta-analysis DOI
Zekun Wang,

Kangxiang Ji,

Qi Fang

et al.

Neurological Sciences, Journal Year: 2024, Volume and Issue: 45(11), P. 5129 - 5140

Published: June 19, 2024

Language: Английский

Citations

0
A preliminary clinical study related to vestibular migraine and cognitive dysfunction DOI Creative Commons
Tingting Sun,

Yake Lin,

Yanan Huang

et al.

Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Dec. 23, 2024

Background and purpose Vestibular migraine (VM) is a common clinical disorder with genetic predisposition characterized by recurrent episodes of dizziness/vertigo. Patients often complain the presence cognitive dysfunction manifestations such as memory loss, which causes great distress in daily life. In this study, we will explore characteristics possible risk factors VM-related observing function vestibular status VM patients, laying foundation for further exploration mechanisms dysfunction. Methods This study included 61 patients 30 healthy individuals matched age, gender, education level. All subjects underwent Addenbrooke’s Cognitive Examination-Revised (ACE-R), Dizziness Handicap Inventory (DHI), Hospital Anxiety Depression Scale (HADS), Patient Health Questionnaire-9 (PHQ-9), Generalized Disorder-7 (GAD-7) at first time enrollment. Based on ACE-R scores, group was divided into (VM-CogD) (ACE-R < 86) without (VM-NoCogD) ≥ 86). The VM-CogD categorized based DHI scores mild, moderate, severe dizziness/vertigo subgroups (DHI ≤ 60 > severe). head-shaking test, head-impulse test skew, Romberg Unterberger videonystagmography, caloric to evaluate their including semicircular canals, vestibulo-ocular reflex pathway, vestibulo-spinal pathway. Differential analysis, correlation ROC curve analysis were used analyze influencing above indicators patients. It considered that p -value 0.05 statistically significant, | r| 0.3 indicated good correlation. Results There no significant differences between control (HC) sex, age total score [82 (68.5, 87)], score, memory, verbal fluency, language, visuospatial significantly lower than those HC ( 0.05) percentage horizontal canal (82.0%), ocular motor (49.2%), positive (27.9%), (37.7%), Romberg’s sign (60.7%), Unterberger’s (60.7%) higher 0.05). Comparing VM-NoCogD 86), Canal Paresis (CP) value, years education, duration disease group, CP value negatively correlated r = 0.571, 0.000), 0.526, fluency 0.345, 0.024), language 0.524, 0.340, 0.026) scores. Age functioning 0.384, 0.011), positively 0.504, 0.001) 0.455, 0.002) When cutoff values 25.5, 33, 15.5, 6.5, accuracy predicting highest. DHI, DHI-P, DHI-E, DHI-F, HADS, PHQ-9, GAD-7 presenting moderate dizziness/vertigo, 0.539, 0.008), DHI-F 0.450, 0.031) part 0.415, 0.049) HADS-D 0.008). Conclusion (1) exhibit multifaceted varying degrees dysfunction, affected illness, function; (2) functional disorder, disturbance, conjunction anxiety depression, may participate occurrence development VM.

Language: Английский

Citations

0