Changes in System Hemodynamics During Static Contractions of Upper and Lower Limb Muscles: Influence of Fatigue DOI
А. С. Боровик,

M. A. Pecheritsa,

О. Л. Виноградова

et al.

Физиология человека, Journal Year: 2024, Volume and Issue: 50(4), P. 80 - 91

Published: Oct. 31, 2024

The changes in blood pressure (BP) and heart rate (HR) during exercise grow with the development of muscle fatigue due to activation ergoreflex (ER), which is commonly assessed by post-exercise flow occlusion. However, this approach does not reproduce ER functioning natural conditions little use for testing from receptors lower limb muscles, differ upper muscles metabolic characteristics, are also subject more pronounced as a result physical inactivity various diseases. aim study was compare systemic hemodynamics “natural” severe test rhythmic static contractions thigh or forearm until failure work. Nine young men performed isometric knee extensors wrist flexors while maintaining given load level (40% maximum voluntary effort) 20 s contraction/20 relaxation mode (work duration both tests about 30 min). During tests, BP (Finapres), stroke volume (SV, ModelFlow algorithm) ECG were continuously recorded. Rhythmic groups accompanied an increase HR, SV decreased. As developed, contraction became pronounced. Importantly, potentiated because total peripheral resistance, cardiac output. Thus, different components – vascular component exercise. results obtained must be considered when developing methods assessing hemodynamic control cardiovascular diseases, often associated skeletal ergoreflex.

Language: Английский

Non-invasive vagus nerve stimulation and exercise capacity in healthy volunteers: a randomized trial DOI Creative Commons
Gareth L. Ackland, Amour Patel, Stuart Miller

et al.

European Heart Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Background and Aims Vagal parasympathetic dysfunction is strongly associated with impaired exercise tolerance, indicating that coordinated autonomic control essential for optimizing performance. This study tested the hypothesis neuromodulation by non-invasive transcutaneous vagus nerve stimulation (tVNS) can improve capacity in humans. Methods single-centre, randomized, double-blind, sham-controlled, crossover trial 28 healthy volunteers evaluated effect of bilateral vagal auricular innervation, applied 30 min daily 7 days, on measures cardiorespiratory fitness (peak oxygen consumption (VO2peak)) during progressive to exhaustion. Secondary endpoints included peak work rate, measures, whole blood inflammatory response lipopolysaccharide ex vivo. Results tVNS over consecutive days increased VO2peak 1.04 mL/kg/min (95% CI: .34–1.73; P = .005), compared no change after sham (−0.54 mL/kg/min; 95% −1.52 .45). No carry-over was observed following 2-week washout period. rate (by 6 W; 2–10; .006), heart 4 bpm; 1–7; .011), respiratory breaths/min; 2–6; < .001) at exercise. Analysis transcriptomic serial samples obtained from five participants showed reduced response. Conclusions Non-invasive improves attenuates inflammation, offering an inexpensive, safe, scalable approach capacity.

Language: Английский

Citations

0
Respiratory Sinus Arrhythmia (RSA) Reactivity and Developmental Delay in the Preschool Years DOI Creative Commons
Jane Jiyoun Lee, Eirini Flouri,

Yo Jackson

et al.

Developmental Psychobiology, Journal Year: 2025, Volume and Issue: 67(3)

Published: April 22, 2025

ABSTRACT Children with developmental delay are more likely than their typically developing peers to experience emotional dysregulation. Given that there is evidence respiratory sinus arrhythmia (RSA) reactivity indexes emotion regulation, which in turn tracks motor, language, and cognitive development across the early years, RSA should develop accordingly period differ by status. The present study therefore compared those without (across adaptive, personal–social, motor domains) on growth preschool years (ages 3–5 years) three time points. Results showed global exhibited atypical progression (e.g., excessive or insufficient vagal withdrawal) years. Follow‐up needed determine whether this pattern of persists later childhood.

Language: Английский

Citations

0
Computational Attitudes to Drug Discovery in Neurohumoral Transmission and Signal Transduction DOI
Lucy Mohapatra, Alok Shiomurti Tripathi, Deepak Mishra

et al.

Published: April 17, 2025

Language: Английский

Citations

0
Relationship between regional sympathetic vascular transduction and sympathetic transduction of blood pressure in young adults at rest DOI
Devin G. McCarthy, Massimo Nardone,

Kathryn Pfundt

et al.

AJP Regulatory Integrative and Comparative Physiology, Journal Year: 2024, Volume and Issue: 327(6), P. R528 - R533

Published: Oct. 7, 2024

The majority of studies have used signal-averaged sympathetic transduction blood pressure as a generalized measure transduction. In this analysis, we show that and regional vascular were moderately correlated in healthy adults at rest. moderate strength relationship highlights potential differences between systemic assessments suggests future work should choose the best aligned with research question.

Language: Английский

Citations

1
Changes in Systemic Hemodynamics during Static Contractions of Upper and Lower Limb Muscles: Influence of Fatigue DOI
А. С. Боровик,

M. A. Pecheritsa,

О. Л. Виноградова

et al.

Human Physiology, Journal Year: 2024, Volume and Issue: 50(4), P. 383 - 392

Published: Aug. 1, 2024

Language: Английский

Citations

0
Changes in System Hemodynamics During Static Contractions of Upper and Lower Limb Muscles: Influence of Fatigue DOI
А. С. Боровик,

M. A. Pecheritsa,

О. Л. Виноградова

et al.

Физиология человека, Journal Year: 2024, Volume and Issue: 50(4), P. 80 - 91

Published: Oct. 31, 2024

The changes in blood pressure (BP) and heart rate (HR) during exercise grow with the development of muscle fatigue due to activation ergoreflex (ER), which is commonly assessed by post-exercise flow occlusion. However, this approach does not reproduce ER functioning natural conditions little use for testing from receptors lower limb muscles, differ upper muscles metabolic characteristics, are also subject more pronounced as a result physical inactivity various diseases. aim study was compare systemic hemodynamics “natural” severe test rhythmic static contractions thigh or forearm until failure work. Nine young men performed isometric knee extensors wrist flexors while maintaining given load level (40% maximum voluntary effort) 20 s contraction/20 relaxation mode (work duration both tests about 30 min). During tests, BP (Finapres), stroke volume (SV, ModelFlow algorithm) ECG were continuously recorded. Rhythmic groups accompanied an increase HR, SV decreased. As developed, contraction became pronounced. Importantly, potentiated because total peripheral resistance, cardiac output. Thus, different components – vascular component exercise. results obtained must be considered when developing methods assessing hemodynamic control cardiovascular diseases, often associated skeletal ergoreflex.

Language: Английский

Citations

0