Unravelling age-related gait decline in cerebral palsy: insights into physiological changes and functional implications through an observational study—a French study protocol in a laboratory setting DOI Creative Commons
Anders Gravholt, B. Fernandez, Diana Rimaud

et al.

BMJ Open, Journal Year: 2024, Volume and Issue: 14(11), P. e090096 - e090096

Published: Nov. 1, 2024

Introduction Cerebral palsy (CP) presents a complex neurodevelopmental disorder with spectrum of motor impairments stemming from early brain injury. Whereas CP is traditionally viewed as non-progressive condition, emerging evidence suggests progressive decline in mobility and function, particularly adulthood. Despite the prevalence self-reported age-related gait adults CP, objective supporting this phenomenon remains limited. Moreover, mechanistic insights into these functional alterations their comparison typically developing (TD) peers are lacking. To address gap, our study aims to objectively assess changes performance among individuals while examining physiological differences compared TD peers. Methods analysis This protocol will compare without within two age groups (18–25 35–50 years old). Participants at Gross Motor Function Classification System levels I–II 18 be invited partake study. Every participant complete four visits investigating wide range related measures: walking performance, muscle strength, cardiopulmonary fatigability, cost quantitative analysis. Through comprehensive encompassing metrics, outcomes, biomechanics metabolical walking, we seek elucidate underlying mechanisms driving inform targeted interventions maintain function quality life. Ethics dissemination The has been approved by French ethics board (#2022-A02510-43) communicated through conferences, articles participants layman terms. Trial registration number NCT06163950 .

Language: Английский

Unravelling age-related gait decline in cerebral palsy: insights into physiological changes and functional implications through an observational study—a French study protocol in a laboratory setting DOI Creative Commons
Anders Gravholt, B. Fernandez, Diana Rimaud

et al.

BMJ Open, Journal Year: 2024, Volume and Issue: 14(11), P. e090096 - e090096

Published: Nov. 1, 2024

Introduction Cerebral palsy (CP) presents a complex neurodevelopmental disorder with spectrum of motor impairments stemming from early brain injury. Whereas CP is traditionally viewed as non-progressive condition, emerging evidence suggests progressive decline in mobility and function, particularly adulthood. Despite the prevalence self-reported age-related gait adults CP, objective supporting this phenomenon remains limited. Moreover, mechanistic insights into these functional alterations their comparison typically developing (TD) peers are lacking. To address gap, our study aims to objectively assess changes performance among individuals while examining physiological differences compared TD peers. Methods analysis This protocol will compare without within two age groups (18–25 35–50 years old). Participants at Gross Motor Function Classification System levels I–II 18 be invited partake study. Every participant complete four visits investigating wide range related measures: walking performance, muscle strength, cardiopulmonary fatigability, cost quantitative analysis. Through comprehensive encompassing metrics, outcomes, biomechanics metabolical walking, we seek elucidate underlying mechanisms driving inform targeted interventions maintain function quality life. Ethics dissemination The has been approved by French ethics board (#2022-A02510-43) communicated through conferences, articles participants layman terms. Trial registration number NCT06163950 .

Language: Английский

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