Pflügers Archiv - European Journal of Physiology, Journal Year: 2024, Volume and Issue: 476(12), P. 1777 - 1778
Published: Nov. 11, 2024
Language: Английский
Biophysical Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
Language: Английский
Citations
1
Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 3, 2025
Recent experimental findings indicate that cancer stem cells originate from transformed very small embryonic-like cells. This finding represents an essential advancement in uncovering the processes drive onset and progression of cancer. In continuously growing cell lines, for first time, our team's follow-up research on leukemia, lung cancer, healthy embryonic kidney revealed stages resembles precursor review explores origin leukemic stem-like establish We explore theoretical model acute myeloid leukemia initiation progresses through various stages, as well basing HL60 line, present its hierarchical stage development vitro, highlighting role these primitive stages. also discuss potential implications further into unique cellular advancing treatment prevention.
Language: Английский
Citations
0
PubMed, Journal Year: 2025, Volume and Issue: unknown
Published: March 5, 2025
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: May 24, 2025
Abstract Colorectal cancer (CRC) poses a significant threat to global public health, and immunotherapy has emerged as promising alternative its treatment. Nevertheless, owing the tumor immunosuppressive microenvironment (TIME), efficacy of single‐agent remains limited. Herein, CSZ@Gel is designed by co‐loading cyclic diguanosine (CDG) siXkr8 in zeolitic imidazolate framework‐8 (ZIF‐8) nanoparticles subsequently integrating them into α‐tocopherol polyethylene glycol succinate (TPGS) hydrogels. ZIF‐8 found undergo degradation under acidic conditions releasing cargo Zn 2+ induce cell pyroptosis. CDG triggers activation stimulator interferon genes (STING) pathway, leading enhanced release proinflammatory cytokines release, dendritic (DC) maturation CD8 + T infiltration. inhibits expression scramblase mXkr8 decreases phosphatidylserine translocation surface, thus decreasing immature DCs regulatory cells (Tregs) reversing TIME. In murine CRC model, exhibits growth suppression effects, extends median survival time mice more than 60 days, significantly recurrence after resection long‐term synergistic anti‐tumor immune activation. These findings suggest that provides an innovative drug delivery platform with clinical translation potential through comprehensive strategies for sustained immunotherapy.
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 979 - 979
Published: July 24, 2024
Despite progress in the management of patients with retinal vascular and degenerative diseases, there is still an unmet clinical need for safe effective therapeutic options novel mechanisms action. Recent mechanistic insights into pathogenesis diseases a prominent component, such as vein occlusion (RVO), diabetic retinopathy (DR) wet age-related macular degeneration (AMD), may open up new treatment paradigms that reach beyond inhibition endothelial growth factor (VEGF). Phosphatidylserine (PS) lipid target linked to pathophysiology several human including diseases. PS acts upstream VEGF complement signaling pathways. Annexin A5 protein targets inhibits signaling. This review explores current understanding potential roles therapeutic. The development status utility PS-Annexin theranostic pairing conditions particular described.
Language: Английский
Citations
0
Pflügers Archiv - European Journal of Physiology, Journal Year: 2024, Volume and Issue: 476(12), P. 1777 - 1778
Published: Nov. 11, 2024
Language: Английский
Citations
0