Early-life stress differentially affects CA3 synaptic inputs converging on apical and basal dendrites of CA1 pyramidal neurons DOI Creative Commons
David Jappy,

Rostislav I. Sokolov,

Yulia V. Dobryakova

et al.

Frontiers in Neural Circuits, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 19, 2025

There is evidence that stress factors and negative experiences in early life may affect brain development leading to mental disorders adulthood. At the stage of postnatal ontogenesis, central nervous system has high plasticity, which decreases with maturation. Most likely, this plasticity necessary for establishing synaptic connections between different types neurons, regulating strength individual synapses, ultimately forming properly functioning neuronal networks. The vast majority studies have examined effects early-life (ELS) on gene expression or behavior memory. However, impact ELS functional plastic properties excitatory inhibitory synapses are currently much less understood. Based data obtained a few it been suggested reduces long-term potentiation (LTP) at Schaffer collateral CA1 pyramidal cell Nevertheless, groups reported somewhat contradictory results. In report we show differentially affects LTP CA3 inputs, apical dendrites reduced, while formed by cells basal remains unaffected.

Language: Английский

Early-life stress differentially affects CA3 synaptic inputs converging on apical and basal dendrites of CA1 pyramidal neurons DOI Creative Commons
David Jappy,

Rostislav I. Sokolov,

Yulia V. Dobryakova

et al.

Frontiers in Neural Circuits, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 19, 2025

There is evidence that stress factors and negative experiences in early life may affect brain development leading to mental disorders adulthood. At the stage of postnatal ontogenesis, central nervous system has high plasticity, which decreases with maturation. Most likely, this plasticity necessary for establishing synaptic connections between different types neurons, regulating strength individual synapses, ultimately forming properly functioning neuronal networks. The vast majority studies have examined effects early-life (ELS) on gene expression or behavior memory. However, impact ELS functional plastic properties excitatory inhibitory synapses are currently much less understood. Based data obtained a few it been suggested reduces long-term potentiation (LTP) at Schaffer collateral CA1 pyramidal cell Nevertheless, groups reported somewhat contradictory results. In report we show differentially affects LTP CA3 inputs, apical dendrites reduced, while formed by cells basal remains unaffected.

Language: Английский

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