Non-Coding RNA: A Key Regulator in the Glutathione-GPX4 Pathway of Ferroptosis

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(4), P. 1222 - 1234

Published: May 20, 2024

Ferroptosis, a form of regulated cell death, has emerged as crucial process in diverse pathophysiological states, encompassing cancer, neurodegenerative ailments, and ischemia-reperfusion injury. The glutathione (GSH)-dependent lipid peroxidation pathway, chiefly governed by peroxidase 4 (GPX4), assumes an essential part driving ferroptosis. GPX4, the principal orchestrator ferroptosis, garnered significant attention across cardiovascular, neuroscience domains over past decade. Noteworthy investigations have elucidated indispensable functions ferroptosis numerous diseases, including tumorigenesis, wherein robust within cells can impede tumor advancement. Recent research underscored complex regulatory role non-coding RNAs (ncRNAs) regulating GSH-GPX4 network, thus influencing cellular susceptibility to This exhaustive review endeavors probe into multifaceted processes which ncRNAs control network Specifically, we delve miRNAs, lncRNAs, circRNAs GPX4 expression impacting Moreover, discuss clinical implications dysregulated interactions between several conditions, underscoring their capacity viable targets for therapeutic intervention. Additionally, explores emerging strategies aimed at targeting modulate pathway manipulate advantage. A comprehensive understanding these intricate networks furnishes insights innovative avenues diseases associated with perturbed thereby laying groundwork interventions ferroptosis-related pathological conditions.

Language: Английский

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Functional Characterization Methods for Non-coding RNAs

Published: Jan. 1, 2025

Language: Английский

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The Emerging Applications of Artificial MicroRNA-Mediated Gene Silencing in Plant Biotechnology

Non-Coding RNA, Journal Year: 2025, Volume and Issue: 11(2), P. 19 - 19

Published: March 2, 2025

Improving crop yield potential is crucial to meet the increasing demands of a rapidly expanding global population in an ever-changing and challenging environment. Therefore, different technological approaches have been proposed over last decades accelerate plant breeding. Among them, artificial microRNAs (amiRNAs) represent innovative tool with remarkable assist improvement. MicroRNAs (miRNAs) are group endogenous, small (20-24 nucleotides), non-coding RNA molecules that play role gene regulation. They associated most biological processes plant, including reproduction, development, cell differentiation, biotic abiotic stress responses, metabolism, architecture. In this context, amiRNAs synthetic engineered mimic structure function endogenous miRNAs, allowing for targeted silencing specific nucleic acids. The current review explores diverse applications biology agriculture, such as management infectious agents pests, engineering enhancement resilience stress. Moreover, we address future perspectives on amiRNA-based strategies, highlighting need further research fully comprehend technology translate its scope toward widespread adoption strategies

Language: Английский

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The Role of Long Non-Coding RNAs in Modulating the Immune Microenvironment of Triple-Negative Breast Cancer: Mechanistic Insights and Therapeutic Potential

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 454 - 454

Published: March 20, 2025

Triple-negative breast cancer (TNBC) is a highly heterogeneous and aggressive subtype of that faces therapeutic challenges due to shortage effective targeted therapies. The complex biology TNBC renders its clinical management fraught with difficulties, especially regarding the immune microenvironment tumor. In recent years, long non-coding RNAs (lncRNAs) have been recognized as important gene regulators key roles in tumor development microenvironmental regulation. Previous studies shown lncRNAs play TNBC, including regulation escape function tumor-infiltrating cells. However, despite increasing research on lncRNAs, there are still many unanswered questions, such their specific mechanism action how effectively utilize them targets. Therefore, aim this study was review mechanisms microenvironment, explore regulatory cell infiltration, prospects potential By integrating latest results, aims provide new ideas directions for future treatment.

Language: Английский

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The future of genome editing in plants

Nature Plants, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Molecular tools for genome editing in plants: a synthetic overview

Vegetable Research, Journal Year: 2025, Volume and Issue: 5(1), P. 0 - 0

Published: Jan. 1, 2025

Language: Английский

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MicroRNAs in Plants Development and Stress Resistance

Plant Cell & Environment, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

ABSTRACT Plant growth and development are governed by a rigorously timed sequence of ontogenetic programmes. MicroRNAs (miRNAs), class short noncoding RNAs, function as master regulators gene expression targeting mRNAs for cleavage or direct translational inhibition at the posttranscriptional level in eukaryotes. Numerous miRNA molecules that control significant agronomic properties plants have been found. On one hand, miRNAs target transcription factors (TFs) to determine plant structure, such root development, internode elongation, leaf morphogenesis, sex determination nutrient transition. other alter levels adapt biological abiotic stresses, including fungi, bacteria, viruses, drought, waterlogging, high temperature, low salinity, deficiencies, heavy metals stresses. To fully understand role plants, we review regulatory stress resistance. Beyond that, propose novel can be effectively further studied with artificial (amiRNA) tandem mimics (STTM) delivery vitro used improve crop yield agricultural sustainability.

Language: Английский

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Mitochondrial microRNAs (mitomiRs) as emerging biomarkers and therapeutic targets for chronic human diseases

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Mitochondria are membrane-bound cell organelles that undertake the majority of energetic and metabolic processes within cell. They also responsible for mediating multiple apoptotic pathways, balancing redox charges, scavenging reactive oxygen species. MicroRNAs, which short, non-coding RNAs widely known regulating gene expression at post-transcriptional level, regulate many these processes. The specific microRNAs directly or indirectly control mitochondrial dynamics called miRNAs (mitomiRs). broadest classification this type ncRNA encompasses nuclear-encoded interact with cytoplasmatic mRNAs associated activity. At same time, a more subset comprises translocate into mitochondria to inside organelle. Finally, smallest group mitomiRs includes those codified by mtDNA can endogenous transcripts be transported cytoplasm modulate circulating mRNAs. Regardless origin action mechanism, have been recently recognized key role in progression variety chronic disorders, such as neurodegenerative cardiovascular diseases, diabetes, asthma, depression, even cancer. All progressive pathologies tightly linked dysregulation. further an aberrant cellular metabolism, positioning reliable biomarkers diagnosing several diseases. These molecular indicators provided insights how conditions progress, allowing development different miRNA-based treatment strategies target dysregulated mitochondrial-related genes, reestablishing their baseline activity restricting disease progression.

Language: Английский

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Update on functional analysis of long non-coding RNAs in common crops

Frontiers in Plant Science, Journal Year: 2024, Volume and Issue: 15

Published: May 30, 2024

With the rapid advances in next-generation sequencing technology, numerous non-protein-coding transcripts have been identified, including long noncoding RNAs (lncRNAs), which are functional comprising more than 200 nucleotides. Although lncRNA-mediated regulatory processes extensively investigated animals, there has considerably less research on plant lncRNAs. Nevertheless, multiple studies major crops showed lncRNAs involved crucial processes, growth and development, reproduction, stress responses. This review summarizes progress lncRNA roles several crops, presents key strategies for exploring discusses current challenges future prospects. The insights provided this will enhance our comprehension of functions with potential implications improving crop genetics breeding.

Language: Английский

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Genomic Precision: Unveiling the Transformative Role of Genome Editing in Advancing Genomics Research and Applications

Published: Jan. 1, 2024

Language: Английский

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