A molecular and immunohistochemical study of 37 cases of ovarian Sertoli–Leydig cell tumor DOI Creative Commons
Kristýna Němejcová, Nikola Hájková,

Eva Krkavcová

et al.

Virchows Archiv, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Abstract This study provides an analysis of 37 ovarian Sertoli–Leydig cell tumors (SLCT), focusing on their morphological, immunohistochemical, and molecular features. The cohort was comprised 9 well-differentiated, 25 moderately differentiated, 3 poorly differentiated tumors. immunohistochemical performed with 28 markers, including diagnostic markers possible predictive significance. results showed high expression sex cord (FOXL2, SF1, inhibin A, CD99, calretinin, ER, PR, AR), variable other such as CKAE1/3 (83%), CAIX (14%), MUC4 (1%). Loss PTEN present in 14% cases, CTLA4 seen 43% cases. All were MMR proficient HER2 PD-L1 negative. DICER1 mutations 54.5% a FOXL2 mutation 6% In addition, we detected 2 cases TERT promoter mutation. RNA NGS sequencing identified significant differences mRNA between MUT WT increased PRKCA , HNF1A LDLR MAP2K5 . On the contrary, CDK6 NOTCH2 FGFR2 our show that SLCTs exhibit distinct features based degree differentiation. We have confirmed are characteristic SLCTs, while well-differentiated may represent entity. different profiles. is less common these mutually exclusive

Language: Английский

Complex immunohistochemical and molecular study on 5 cases of ovarian juvenile granulosa cell tumors reveals a consistent alteration in the PI3K/AKT/mTOR signaling pathway DOI Creative Commons
Adam Šafanda, Nikola Hájková, Michaela Bártů

et al.

Diagnostic Pathology, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 8, 2025

Language: Английский

Citations

0
The molecular landscape of 227 adult granulosa cell tumors of the ovary: Insights into the progression from primary to recurrence DOI
Romana Michálková, Adam Šafanda, Nikola Hájková

et al.

Laboratory Investigation, Journal Year: 2024, Volume and Issue: unknown, P. 102201 - 102201

Published: Nov. 1, 2024

Language: Английский

Citations

1
A molecular and immunohistochemical study of 37 cases of ovarian Sertoli–Leydig cell tumor DOI Creative Commons
Kristýna Němejcová, Nikola Hájková,

Eva Krkavcová

et al.

Virchows Archiv, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Abstract This study provides an analysis of 37 ovarian Sertoli–Leydig cell tumors (SLCT), focusing on their morphological, immunohistochemical, and molecular features. The cohort was comprised 9 well-differentiated, 25 moderately differentiated, 3 poorly differentiated tumors. immunohistochemical performed with 28 markers, including diagnostic markers possible predictive significance. results showed high expression sex cord (FOXL2, SF1, inhibin A, CD99, calretinin, ER, PR, AR), variable other such as CKAE1/3 (83%), CAIX (14%), MUC4 (1%). Loss PTEN present in 14% cases, CTLA4 seen 43% cases. All were MMR proficient HER2 PD-L1 negative. DICER1 mutations 54.5% a FOXL2 mutation 6% In addition, we detected 2 cases TERT promoter mutation. RNA NGS sequencing identified significant differences mRNA between MUT WT increased PRKCA , HNF1A LDLR MAP2K5 . On the contrary, CDK6 NOTCH2 FGFR2 our show that SLCTs exhibit distinct features based degree differentiation. We have confirmed are characteristic SLCTs, while well-differentiated may represent entity. different profiles. is less common these mutually exclusive

Language: Английский

Citations

0