Communications Biology,
Journal Year:
2023,
Volume and Issue:
6(1)
Published: Aug. 14, 2023
Abstract
Transient
ischemic
attack
(TIA)
is
a
temporary
episode
of
neurological
dysfunction
that
results
from
focal
brain
ischemia.
Although
TIA
symptoms
are
quickly
resolved,
patients
with
have
high
risk
stroke
and
persistent
impairments
in
multiple
domains
cognitive
motor
functions.
In
this
study,
using
spectral
dynamic
causal
modeling,
we
investigate
the
changes
task-residual
effective
connectivity
during
fist-closing
movements.
28
healthy
participants
15
age-matched
undergo
functional
magnetic
resonance
imaging
at
7T.
Here
show
visually
cued
movement,
significantly
higher
toward
ipsilateral
primary
cortex
lower
to
supplementary
area
than
controls.
Our
imply
aberrant
connections
among
regions,
these
may
reflect
decreased
efficiency
function
disrupted
control
voluntary
movement
TIA.
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: May 26, 2023
Abstract
The
aim
of
this
study
was
to
characterize
expression
corticogenesis-related
transcription
factors
BCL11B
and
SATB2
after
brain
ischemic
lesion
in
the
adult
mice,
analyze
their
correlation
subsequent
recovery.
Ischemic
induced
by
transient
middle
cerebral
artery
occlusion
followed
reperfusion,
animals
with
were
compared
sham
controls.
Progression
damage
recovery
longitudinally
monitored
structurally,
magnetic
resonance
imaging,
functionally,
neurological
deficit
assessment.
Seven
days
injury
brains
isolated
analyzed
immunohistochemistry.
results
showed
higher
both,
co-expression
both
markers,
SATB2,
increased
brains,
as
well
beneficial
transcriptional
factor
ATF3
but
not
its
detrimental
HDAC2.
mainly
implicated
ipsilateral
contralateral
hemisphere,
level
these
regions
correlated
functional
rate.
indicate
that
reactivation
is
lesion.
Frontiers in Neurology,
Journal Year:
2023,
Volume and Issue:
14
Published: June 30, 2023
The
traditional
approach
to
studying
the
neurobiological
mechanisms
of
brain
disorders
and
localizing
function
involves
identifying
abnormalities
comparing
them
matched
controls.
This
method
has
been
instrumental
in
clinical
neurology,
providing
insight
into
functional
roles
different
regions.
However,
it
becomes
challenging
when
lesions
diverse
regions
produce
similar
symptoms.
To
address
this,
researchers
have
begun
mapping
or
structural
networks,
a
process
known
as
lesion
network
(LNM).
seeks
identify
common
circuits
associated
with
various
areas.
In
this
review,
we
focus
on
recent
studies
that
utilized
LNM
map
neurological
psychiatric
symptoms,
shedding
light
how
enhances
our
understanding
functions.We
conducted
systematic
search
four
databases:
PubMed,
Scopus,
Web
Science,
using
term
"Lesion
mapping."
Our
was
observational
applied
context
disorders.Following
screening
process,
included
52
studies,
comprising
total
6,814
subjects,
review.
These
which
connectivity,
revealed
several
overlaps
across
movement
disorders.
For
instance,
cerebellum
found
be
part
for
conditions
such
essential
tremor
relief,
parkinsonism,
Holmes
tremor,
freezing
gait,
cervical
dystonia,
infantile
spasms,
tics.
Additionally,
thalamus
identified
executive
deficits.
dorsal
attention
significantly
fall
risk
elderly
individuals
parkinsonism.LNM
proven
powerful
tool
broad
range
neuropsychiatric,
behavioral,
It
holds
promise
new
treatment
targets
through
symptom
mapping.
Nonetheless,
validity
these
approaches
should
confirmed
by
more
comprehensive
prospective
studies.
Brain Structure and Function,
Journal Year:
2022,
Volume and Issue:
227(9), P. 2897 - 2908
Published: Oct. 3, 2022
Cognitive
functional
neuroimaging
has
been
around
for
over
30
years
and
shed
light
on
the
brain
areas
relevant
reading.
However,
new
methodological
developments
enable
mapping
interaction
between
imaging
underlying
white
matter
networks.
In
this
study,
we
used
such
a
novel
method,
called
disconnectome,
to
decode
reading
circuitry
in
brain.
We
resulting
disconnection
patterns
predict
typical
lesion
that
would
lead
deficits
after
damage.
Our
results
suggest
connections
critical
include
fronto-parietal
U-shaped
fibres
vertical
occipital
fasciculus
(VOF).
The
most
predictive
of
deficit
impinge
left
temporal,
occipital,
inferior
parietal
gyri.
This
framework
can
systematically
be
applied
bridge
gap
neuropathology
language
cognitive
neuroscience.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 24, 2024
Structural
disconnectome
analyses
have
provided
valuable
insights
into
how
a
stroke
lesion
results
in
widespread
network
disturbances
and
these
relate
to
deficits,
recovery
patterns,
outcome.
Previous
primarily
focused
on
patients
with
relatively
mild
moderate
deficits.
However,
outcomes
vary
among
survivors
of
severe
strokes,
the
mechanisms
remain
poorly
understood.
This
study
assesses
association
between
lesion-induced
disconnection
outcome
after
stroke.
Thirty-eight
ischaemic
underwent
MRI
brain
imaging
early
longitudinal
clinical
follow-up.
Lesion
information
was
integrated
normative
connectome
data
infer
individual
profiles
localized
regional
region-to-region
pathway
level.
Ordinal
logistic
regressions
were
computed
link
modified
Rankin
Scale
3-6
months.
Disconnections
ipsilesional
frontal,
parietal
temporal
cortical
areas
significantly
associated
worse
motor
stroke,
adjusted
for
initial
deficit,
volume,
age.
The
analysis
underlying
pathways
mediating
this
revealed
location
specific
results:
For
prefrontal
areas,
driven
by
sparse
intrahemispheric
disconnections.
In
contrast,
primary
cortex,
dorsal
premotor
various
regions
showed
remarkable
involvement
either
frontoparietal
or
additionally
interhemispheric
These
indicate
that
multiple
embedded
structural
correlates
Specifically,
cortices
might
gain
particular
importance
as
they
structurally
networks
both
hemispheres.
shed
novel
light
significance
distinct
Frontiers in Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: Aug. 9, 2024
The
interrelation
between
acute
ischemic
stroke,
persistent
disability,
and
uncertain
prognosis
underscores
the
need
for
improved
methods
to
predict
clinical
outcomes.
Traditional
approaches
have
largely
focused
on
analysis
of
metrics,
lesion
characteristics,
network
connectivity,
using
techniques
such
as
resting-state
functional
magnetic
resonance
imaging
(rs-fMRI)
diffusion
tensor
(DTI).
However,
these
are
not
routinely
used
in
stroke
diagnostics.
This
study
introduces
an
innovative
approach
that
only
considers
size
relation
National
Institutes
Health
Stroke
Scale
(NIHSS
score),
but
also
evaluates
impact
disrupted
fibers
their
connections
cortical
regions
by
introducing
a
disconnection
value.
By
identifying
traversing
estimating
number
within
predefined
interest
(ROIs)
normative
connectome
atlas,
our
method
bypasses
individual
DTI
scans.
In
MRI
data
(T1
T2)
from
51
patients
with
or
subacute
subcortical
presenting
motor
sensory
deficits,
we
simple
linear
regression
assess
explanatory
power
value
NIHSS
score.
Subsequent
hierarchical
multiple
determined
incremental
metrics
over
alone
Our
results
showed
models
incorporating
accounted
more
variance
than
those
based
solely
(lesion
explained
44%
variance,
60%).
Furthermore,
revealed
significant
improvement
(
Human Brain Mapping,
Journal Year:
2024,
Volume and Issue:
45(16)
Published: Nov. 1, 2024
ABSTRACT
Structural
disconnectome
analyses
have
provided
valuable
insights
into
how
a
stroke
lesion
results
in
widespread
network
disturbances
and
these
relate
to
deficits,
recovery
patterns,
outcomes.
Previous
primarily
focused
on
patients
with
relatively
mild
moderate
deficits.
However,
outcomes
vary
among
survivors
of
severe
strokes,
the
mechanisms
remain
poorly
understood.
This
study
assesses
association
between
lesion‐induced
disconnection
outcome
after
stroke.
Thirty‐eight
ischaemic
underwent
MRI
brain
imaging
early
longitudinal
clinical
follow‐up.
Lesion
information
was
integrated
normative
connectome
data
infer
individual
profiles
localized
regional
region‐to‐region
pathway
level.
Ordinal
logistic
regressions
were
computed
link
modified
Rankin
Scale
3–6
months.
Disconnections
ipsilesional
frontal,
parietal,
temporal
cortical
areas
significantly
associated
worse
motor
stroke,
adjusted
for
initial
deficit,
volume,
age.
The
analysis
underlying
pathways
mediating
this
revealed
location‐specific
results:
For
prefrontal,
areas,
driven
by
sparse
intrahemispheric
disconnections.
In
contrast,
primary
cortex,
dorsal
premotor
various
parietal
regions
showed
remarkable
involvement
either
frontoparietal
or
additionally
interhemispheric
These
indicate
that
multiple
embedded
structural
correlates
Specifically,
cortices
might
gain
particular
importance
as
they
structurally
networks
both
hemispheres.
shed
novel
light
significance
distinct
Communications Biology,
Journal Year:
2023,
Volume and Issue:
6(1)
Published: Aug. 14, 2023
Abstract
Transient
ischemic
attack
(TIA)
is
a
temporary
episode
of
neurological
dysfunction
that
results
from
focal
brain
ischemia.
Although
TIA
symptoms
are
quickly
resolved,
patients
with
have
high
risk
stroke
and
persistent
impairments
in
multiple
domains
cognitive
motor
functions.
In
this
study,
using
spectral
dynamic
causal
modeling,
we
investigate
the
changes
task-residual
effective
connectivity
during
fist-closing
movements.
28
healthy
participants
15
age-matched
undergo
functional
magnetic
resonance
imaging
at
7T.
Here
show
visually
cued
movement,
significantly
higher
toward
ipsilateral
primary
cortex
lower
to
supplementary
area
than
controls.
Our
imply
aberrant
connections
among
regions,
these
may
reflect
decreased
efficiency
function
disrupted
control
voluntary
movement
TIA.
