The songbird connectome (OSCINE-NET.ORG): structure–function organization beyond the canonical vocal control network DOI Creative Commons

Andrew Savoy,

Katherine L. Anderson, Joseph V. Gogola

et al.

BMC Neuroscience, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 27, 2024

Understanding the neural basis of behavior requires insight into how different brain systems coordinate with each other. Existing connectomes for various species have highlighted essential to aspects behavior, yet their application complex learned behaviors remains limited. Research on vocal learning in songbirds has extensively focused control network, though recent work implicates a variety circuits contributing important behavior. Thus, more comprehensive understanding brain-wide connectivity is further assess totality circuitry underlying this We present Oscine Structural Connectome Investigating NEural NETwork ORGanization (OSCINE-NET.ORG), first interactive mesoscale connectome any learner. This digital map includes all known data, covering major superstructures and functional networks. Our analysis reveals that songbird exhibits small-world properties, highly connected communities functionally designated as motor, visual, associative, vocal, social, auditory. Moreover, there small set significant connections across these communities, including from social auditory sub-communities sub-communities, which highlight ethologically relevant facets production. Notably, community contains majority canonical well other nodes are interconnected it, meriting evaluation inclusion network. A subset forms "rich broker club," forming circuit amongst themselves, indicating they may play key role information transfer broadly. Collectively, bidirectional multiple indicates act liaisons behaviors. OSCINE-NET.ORG offers unprecedented access detailed promoting data emphasizes importance integration learning, facilitating potential reevaluation Furthermore, we computationally identify small, previously unidentified circuit-one an impactful coordination

Language: Английский

Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species DOI Creative Commons
Virginie Rappeneau, Fernando Castillo Díaz

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 161, P. 105675 - 105675

Published: April 11, 2024

Social behaviours are essential for animal survival, and the hypothalamic neuropeptide oxytocin (OXT) critically impacts bonding, parenting, decision-making. Dopamine (DA), is released by ventral tegmental area (VTA) dopaminergic neurons, regulating social cues in mesolimbic system. Despite extensive exploration of OXT DA roles behaviour independently, limited studies investigate their interplay. This narrative review integrates insights from human studies, particularly rodents, emphasising recent research on pharmacological manipulations or systems behaviour. Additionally, we correlating with blood/cerebral levels. Behavioural facets include sociability, cooperation, pair bonding parental care. In addition, provide into OXT-DA interplay models stress, autism schizophrenia. Emphasis placed complex relationship between collective influence across physiological pathological conditions. Understanding imbalance fundamental unravelling neurobiological underpinnings interaction reward processing deficits observed psychiatric

Language: Английский

Citations

10
Neurocognitive Psychiatric and Neuropsychological Alterations in Parkinson’s Disease: A Basic and Clinical Approach DOI Creative Commons

Héctor González-Usigli,

Genaro Gabriel Ortíz, Claudia Charles‐Niño

et al.

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(3), P. 508 - 508

Published: March 18, 2023

The main histopathological hallmarks of Parkinson’s disease (PD) are the degeneration dopaminergic neurons substantia nigra pars compacta and loss neuromelanin as a consequence decreased dopamine synthesis. destruction striatal pathway blocking receptors cause motor deficits in humans experimental animal models induced by some environmental agents. In addition, neuropsychiatric symptoms such mood anxiety disorders, hallucinations, psychosis, cognitive impairment, dementia common PD. These alterations may precede appearance correlated with neurochemical structural changes brain. This paper reviews most crucial pathophysiology It is worth noting that PD patients have global task learning deficits, functions compromised way associated hypoactivation within striatum, anterior cingulate cortex, inferior frontal sulcus regions. An appropriate extensive neuropsychological screening battery must accurately assess at least five domains tests for each domain. should consider pathophysiological clinical heterogeneity dysfunction

Language: Английский

Citations

15
The Songbird Connectome (OSCINE-NET.ORG): Structure-Function Organization Beyond the Canonical Vocal Control Network DOI Creative Commons

Andrew Savoy,

Katherine L. Anderson, Joseph V. Gogola

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

Abstract Background Understanding the neural basis of behavior requires insight into how different brain systems coordinate. Existing connectomes for various species have highlighted essential to aspects behavior, yet their application complex learned behaviors remains limited. Vocal learning in songbirds has extensively focused on vocal control network, though recent work implicates a variety circuits contributing important behavior. Thus, more comprehensive understanding brain-wide connectivity is further assess totality circuitry underlying this Results We present Oscine Structural Connectome Investigating NEural NETwork ORGanization (OSCINE-NET.ORG), first interactive mesoscale connectome any learner. This digital map includes all known data, covering major superstructures and functional networks. Our analysis reveals that songbird exhibits small-world properties, with highly connected communities functionally designated as motor, visual, associative, vocal, social, auditory. Moreover, there small set significant connections across these communities, including from social auditory sub-communities sub-communities, which highlight ethologically relevant facets production. Notably, community contains majority canonical well other nodes are interconnected it, meriting evaluation inclusion network. A subset forms "rich broker club," forming circuit amongst themselves, indicating they may play key role information transfer broadly. Collectively, bidirectional multiple indicates act liaisons behaviors. Conclusions OSCINE-NET.ORG offers unprecedented access detailed promoting data emphasizes importance integration learning, facilitating potential reevaluation Furthermore, we identify small, previously unidentified circuit—one an impactful coordination

Language: Английский

Citations

0
Solitude and serotonin: juvenile isolation alters the covariation between social behavior and cFos expression by serotonergic neurons DOI Creative Commons

Sarah Hutchens,

Izza Khurram,

Laura M. Hurley

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 22, 2024

Variation in the mutual responsiveness of social partners to each other can be reflected behavioral suites that covary with neural activity ways track salience or valence interactions. Juvenile isolation alters behavior and during interaction, but whether how it covariation between has not been as well explored. To address this issue, four classes experimental subjects: isolated males, socially housed females, were paired an opposite-sex partner had housed. Social behaviors c-Fos expression serotonergic dorsal raphe nucleus (DRN) then measured subjects following Relative housing, postweaning led a decrease density neurons double-labeled for tryptophan hydroxylase dorsomedial subdivision DRN, regardless sex. Vocal non-vocal also affected by isolation. In interactions both ultrasonic vocalization (USVs) broadband vocalizations (squeaks) increased conjunction greater male investigation females. Neural measures correlated other. group, DRN was negatively USV production positively principal component corresponding defensive kicking females less mounting behavior. This correlation reversed direction males versus These findings confirm dynamics are activation suggest altered interaction parallel response female cues.

Language: Английский

Citations

0
The songbird connectome (OSCINE-NET.ORG): structure–function organization beyond the canonical vocal control network DOI Creative Commons

Andrew Savoy,

Katherine L. Anderson, Joseph V. Gogola

et al.

BMC Neuroscience, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 27, 2024

Understanding the neural basis of behavior requires insight into how different brain systems coordinate with each other. Existing connectomes for various species have highlighted essential to aspects behavior, yet their application complex learned behaviors remains limited. Research on vocal learning in songbirds has extensively focused control network, though recent work implicates a variety circuits contributing important behavior. Thus, more comprehensive understanding brain-wide connectivity is further assess totality circuitry underlying this We present Oscine Structural Connectome Investigating NEural NETwork ORGanization (OSCINE-NET.ORG), first interactive mesoscale connectome any learner. This digital map includes all known data, covering major superstructures and functional networks. Our analysis reveals that songbird exhibits small-world properties, highly connected communities functionally designated as motor, visual, associative, vocal, social, auditory. Moreover, there small set significant connections across these communities, including from social auditory sub-communities sub-communities, which highlight ethologically relevant facets production. Notably, community contains majority canonical well other nodes are interconnected it, meriting evaluation inclusion network. A subset forms "rich broker club," forming circuit amongst themselves, indicating they may play key role information transfer broadly. Collectively, bidirectional multiple indicates act liaisons behaviors. OSCINE-NET.ORG offers unprecedented access detailed promoting data emphasizes importance integration learning, facilitating potential reevaluation Furthermore, we computationally identify small, previously unidentified circuit-one an impactful coordination

Language: Английский

Citations

0