Neurite density but not myelination of specific fiber tracts links polygenic scores to general intelligence DOI Open Access

Christina Stammen,

Javier Schneider Penate,

Dorothea Metzen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Abstract White matter is fundamental for efficient and accurate information transfer throughout the human brain thus crucial intelligence. Previous studies often demonstrated associations between fractional anisotropy (FA) as a metric of white “microstructural integrity” intelligence, but it still unclear, whether this relation due to greater axon density, parallel, homogenous fiber orientation distributions, or myelination since all these measures influence FA. Using neurite dispersion density imaging (NODDI) myelin water fraction (MWF) data, we analyzed microstructural architecture intelligence in more detail sample 500 healthy young adults. Furthermore, were interested specific indices play intermediary roles pathway that links genetic disposition phenotype. Thus, conducted first time mediation analyses investigating (NDI), (ODI), MWF 64 tracts mediate effects polygenic scores (PGS GI ) on general By doing so, showed NDI, not ODI was significantly associated with NDI six mediated variability g . These findings are step forward decoding neurogenetic underpinnings they identify relates variation , whereas did not.

Language: Английский

Neurite density but not myelination of specific fiber tracts links polygenic scores to general intelligence DOI Open Access

Christina Stammen,

Javier Schneider Penate,

Dorothea Metzen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Abstract White matter is fundamental for efficient and accurate information transfer throughout the human brain thus crucial intelligence. Previous studies often demonstrated associations between fractional anisotropy (FA) as a metric of white “microstructural integrity” intelligence, but it still unclear, whether this relation due to greater axon density, parallel, homogenous fiber orientation distributions, or myelination since all these measures influence FA. Using neurite dispersion density imaging (NODDI) myelin water fraction (MWF) data, we analyzed microstructural architecture intelligence in more detail sample 500 healthy young adults. Furthermore, were interested specific indices play intermediary roles pathway that links genetic disposition phenotype. Thus, conducted first time mediation analyses investigating (NDI), (ODI), MWF 64 tracts mediate effects polygenic scores (PGS GI ) on general By doing so, showed NDI, not ODI was significantly associated with NDI six mediated variability g . These findings are step forward decoding neurogenetic underpinnings they identify relates variation , whereas did not.

Language: Английский

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