Chronic pain is associated with greater brain entropy in the prefrontal cortex

Journal of Pain, Journal Year: 2025, Volume and Issue: unknown, P. 105421 - 105421

Published: April 1, 2025

Chronic pain is a debilitating clinical condition and severe public health issue that demands to be addressed. Neuroimaging-based techniques have been widely adopted investigate the neural underpinnings of chronic pain. Despite efforts complex nature experience as well heterogeneity made identification neuroimaging-based biomarkers extremely challenging. In this study, resting-state fMRI-based brain entropy, measure reflecting "irregularity" activity, was biomarker by comparing individuals with healthy controls in sample middle-to-old-age participants (n > 30,000) drawn from UK Biobank database. Abnormal entropy associated altered dynamics may serve potential marker disrupted processing Compared controls, exhibited increased broad set regions including frontal, temporal, occipital lobes, cerebellum. addition, more distributed showed lobes. When examining distinct types individually, only headache all over body differences compared matched controls. Perspective This article investigates substrates using randomness irregularity activity. could potentially aid assessment treatment

Language: Английский

The relationships of resting-state brain entropy (BEN), ovarian hormones and behavioral inhibition and activation systems (BIS/BAS)

NeuroImage, Journal Year: 2025, Volume and Issue: 312, P. 121226 - 121226

Published: April 21, 2025

Language: Английский