Research Square (Research Square),
Journal Year:
2022,
Volume and Issue:
unknown
Published: June 6, 2022
Abstract
SARS-CoV-2
infection
causes
COVID-19,
a
severe
acute
respiratory
disease
associated
with
cardiovascular
complications
including
long-term
outcomes.
The
presence
of
virus
in
cardiac
tissue
patients
COVID-19
suggests
this
is
direct,
rather
than
secondary,
effect
infection.
By
expressing
individual
proteins
the
Drosophila
heart
we
demonstrated
interaction
Nsp6
host
MGA/MAX
complex
(MGA,
PCGF6
and
TFDP1).
Complementing
transcriptomic
data
from
fly
revealed
that
blocks
antagonistic
complex,
which
shifts
balance
towards
MYC/MAX
activates
glycolysis—with
similar
findings
mouse
cardiomyocytes.
Further,
Nsp6-induced
glycolysis
disrupted
mitochondrial
function,
known
to
increase
reactive
oxygen
species
(ROS)
failure;
could
explain
COVID-19-associated
pathology.
Furthermore,
inhibiting
pathway
by
2-deoxy-D-glucose
(2DG)
treatment
attenuated
phenotype
mice;
thus,
suggesting
as
potential
pharmacological
target
for
treating
failure.
Frontiers in Nutrition,
Journal Year:
2022,
Volume and Issue:
9
Published: Nov. 1, 2022
Many
local
and
systemic
diseases
especially
that
are
leading
causes
of
death
globally
like
chronic
obstructive
pulmonary
disease,
atherosclerosis
with
ischemic
heart
disease
stroke,
cancer
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
causing
19
(COVID-19),
involve
both,
(1)
oxidative
stress
excessive
production
reactive
oxygen
species
(ROS)
lower
glutathione
(GSH)
levels,
(2)
inflammation.
The
GSH
tripeptide
(γ-
L-glutamyl-L-cysteinyl-glycine),
the
most
abundant
water-soluble
non-protein
thiol
in
cell
(1–10
mM)
is
fundamental
for
life
by
(a)
sustaining
adequate
redox
signaling
needed
to
maintain
physiologic
levels
control
processes,
(b)
limiting
tissue
damage.
activity
facilitated
activation
Kelch-like
ECH-associated
protein
1
(Keap1)-Nuclear
factor
erythroid
2-related
(Nrf2)-antioxidant
response
element
(ARE)
regulator
pathway,
releasing
Nrf2
regulates
expression
genes
controlling
antioxidant,
inflammatory
immune
system
responses.
exists
thiol-reduced
(>98%
total
GSH)
disulfide-oxidized
(GSSG)
forms,
concentrations
GSSG
their
molar
ratio
indicators
functionality
cell.
depletion
may
play
a
central
role
COVID-19
pathophysiology,
host
severity
mortality.
Therapies
enhancing
could
become
cornerstone
reduce
fatal
outcomes
increasing
prevent
subdue
these
diseases.
value
makes
paramount
research
field
biology
medicine
be
key
against
inflammation
SARS-CoV-2
infection
disease.
In
this
review,
we
emphasize
on
as
risk
(ischemic
stroke),
importance
antioxidants
(3)
significance
counteract
persistent
damaging
inflammation,
inflammaging
early
(premature)
associated
damage
caused
lack
antioxidant
defenses
younger
individuals,
(4)
new
therapies
include
restoration.
Frontiers in Microbiology,
Journal Year:
2022,
Volume and Issue:
13
Published: Oct. 6, 2022
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
that
causes
disease
19
(COVID-19)
has
numerous
risk
factors
leading
to
severe
with
high
mortality
rate.
Oxidative
stress
excessive
production
of
reactive
oxygen
species
(ROS)
lower
glutathione
(GSH)
levels
seems
be
a
common
pathway
associated
the
COVID-19
mortality.
GSH
is
unique
small
but
powerful
molecule
paramount
for
life.
It
sustains
adequate
redox
cell
signaling
since
physiologic
level
oxidative
fundamental
controlling
life
processes
via
signaling,
oxidation
and
tissue
damage.
The
water-soluble
tripeptide
(γ-L-glutamyl-L-cysteinyl-glycine)
present
in
cytoplasm
all
cells.
at
1–10
mM
concentrations
mammalian
tissues
(highest
concentration
liver)
as
most
abundant
non-protein
thiol
protects
against
stress.
also
activates
Kelch-like
ECH-associated
protein
1
(Keap1)-Nuclear
factor
erythroid
2-related
(Nrf2)-antioxidant
response
element
(ARE)
regulator
pathway,
releasing
Nrf2
regulate
expression
genes
control
antioxidant,
inflammatory
immune
system
responses,
facilitating
activity.
exists
thiol-reduced
disulfide-oxidized
(GSSG)
forms.
Reduced
prevailing
form
accounting
>98%
total
GSH.
GSSG
their
molar
ratio
are
indicators
functionality
its
alteration
related
various
human
pathological
including
COVID-19.
plays
prominent
role
SARS-CoV-2
infection
following
recognition
viral
S-protein
by
angiotensin
converting
enzyme-2
receptor
pattern
receptors
like
toll-like
4,
activation
transcription
nuclear
kappa
B,
subsequently
activate
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
oxidase
(NOX)
succeeded
ROS
production.
depletion
may
have
pathophysiology,
host
severity
Therapies
enhancing
could
become
cornerstone
reduce
fatal
outcomes
increasing
prevent
subdue
disease.
value
makes
research
field
biology
medicine
key
Communications Biology,
Journal Year:
2022,
Volume and Issue:
5(1)
Published: Sept. 30, 2022
Abstract
SARS-CoV-2
infection
causes
COVID-19,
a
severe
acute
respiratory
disease
associated
with
cardiovascular
complications
including
long-term
outcomes.
The
presence
of
virus
in
cardiac
tissue
patients
COVID-19
suggests
this
is
direct,
rather
than
secondary,
effect
infection.
Here,
by
expressing
individual
proteins
the
Drosophila
heart,
we
demonstrate
interaction
Nsp6
host
MGA/MAX
complex
(MGA,
PCGF6
and
TFDP1).
Complementing
transcriptomic
data
from
fly
heart
reveal
that
blocks
antagonistic
complex,
which
shifts
balance
towards
MYC/MAX
activates
glycolysis—with
similar
findings
mouse
cardiomyocytes.
Further,
-induced
glycolysis
disrupts
mitochondrial
function,
known
to
increase
reactive
oxygen
species
(ROS)
failure;
could
explain
COVID-19-associated
pathology.
Inhibiting
pathway
2-deoxy-D-glucose
(2DG)
treatment
attenuates
phenotype
flies
mice.
These
point
as
potential
pharmacological
target
for
treating
failure.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Jan. 18, 2023
Cellular
metabolism
is
essential
for
the
correct
function
of
immune
system
cells,
including
Natural
Killer
cells
(NK).
These
depend
on
energy
to
carry
out
their
effector
functions,
especially
in
early
stages
viral
infection.
NK
participate
innate
response
against
viruses
and
tumors.
Their
main
functions
are
cytotoxicity
cytokine
production.
Metabolic
changes
can
impact
intracellular
signals,
molecule
production,
secretion,
cell
activation
which
as
first
line
defense.
variations
different
a
tumor
or
pathogen
infection
have
been
described;
however,
little
known
about
context
This
review
summarizes
activation-specific
metabolic
immunometabolism
during
early,
late,
chronic
antiviral
responses,
alterations
SARS-CoV2
The
modulation
points
these
routes
also
discussed
explore
potential
new
immunotherapies
infections.
COVID,
Journal Year:
2025,
Volume and Issue:
5(3), P. 41 - 41
Published: March 12, 2025
On
11
March
2020,
the
World
Health
Organization
(WHO)
declared
a
pandemic
caused
by
SARS-CoV-2,
raising
global
health
concerns.
Reports
of
persistent
and
new
symptoms
following
acute
phase
infection
highlighted
complexities
recovery
prompted
investigation
what
is
now
termed
long
COVID.
Officially
recognized
WHO
in
October
2021,
COVID
presents
various
implications,
though
terminology—such
as
post-COVID
syndrome
post-acute
sequelae
COVID-19
(PASC)—remains
inconsistent,
complicating
diagnostic
standardization.
Long
affects
an
estimated
10%
to
30%
SARS-CoV-2-infected
individuals,
with
common
including
fatigue,
dyspnea,
cognitive
dysfunction,
joint
pain,
all
which
significantly
impair
quality
life.
Public
perception
influenced
factors
like
education
history,
while
misinformation
stigma
hinder
accurate
diagnosis
treatment.
The
absence
biomarkers
overlap
other
post-viral
syndromes
further
complicate
clinical
recognition.
Experts
emphasize
need
for
refined
criteria
integrated
strategies
combining
biomedical
research,
public
policy,
educational
initiatives
improve
management,
address
healthcare
inequalities,
mitigate
impacts
This
review
unveils
state
art
knowledge
gaps
encourage
discussion,
aim
achieving
better
decision-making
awareness
related
Viruses,
Journal Year:
2023,
Volume and Issue:
15(2), P. 525 - 525
Published: Feb. 13, 2023
RNA
viruses
are
known
to
induce
a
wide
variety
of
respiratory
tract
illnesses,
from
simple
colds
the
latest
coronavirus
pandemic,
causing
effects
on
public
health
and
economy
worldwide.
Influenza
virus
(IV),
parainfluenza
(PIV),
metapneumovirus
(MPV),
syncytial
(RSV),
rhinovirus
(RhV),
(CoV)
some
most
notable
viruses.
Despite
efforts,
due
high
mutation
rate,
there
still
no
effective
scalable
treatments
that
accompany
rapid
emergence
new
diseases
associated
with
Host-directed
therapies
have
been
applied
combat
infections
by
interfering
host
cell
factors
enhance
ability
immune
cells
respond
against
those
pathogens.
The
reprogramming
metabolism
has
recently
emerged
as
central
mechanism
in
orchestrated
immunity
Therefore,
understanding
metabolic
signature
during
infection
may
be
promising
tool
for
developing
host-directed
therapies.
In
this
review,
we
revisit
recent
findings
immunometabolic
modulation
response
discuss
how
these
pathways
used
targets
illnesses
caused
Life,
Journal Year:
2023,
Volume and Issue:
13(4), P. 1011 - 1011
Published: April 14, 2023
Corona
Virus
Disease
2019
(COVID-19)
not
only
causes
respiratory
system
damage,
but
also
imposes
strain
on
the
cardiovascular
system.
Vascular
endothelial
cells
and
cardiomyocytes
play
an
important
role
in
cardiac
function.
The
aberrant
expression
of
genes
vascular
can
lead
to
diseases.
In
this
study,
we
sought
explain
influence
syndrome
coronavirus
2
(SARS-CoV-2)
infection
gene
levels
cardiomyocytes.
We
designed
advanced
machine
learning-based
workflow
analyze
profile
data
from
patients
with
COVID-19
healthy
controls.
An
incremental
feature
selection
method
a
decision
tree
was
used
building
efficient
classifiers
summarizing
quantitative
classification
rules.
Some
key
genes,
such
as
MALAT1,
MT-CO1,
CD36,
were
extracted,
which
exert
effects
function,
matrix
104,182
cardiomyocytes,
including
12,007
92,175
controls,
22,438
cells,
10,812
11,626
findings
reported
study
may
provide
insights
into
effect
further
pathogenesis
COVID-19,
they
facilitate
identification
potential
therapeutic
targets.
