The Resurgence of Monkeypox: Epidemiology, Clinical Features, and Public Health Implications in the Post-Smallpox Eradication Era
New Microbes and New Infections,
Journal Year:
2024,
Volume and Issue:
62, P. 101487 - 101487
Published: Sept. 24, 2024
Language: Английский
Clinical implement of Probe‐Capture Metagenomics in sepsis patients: A multicentre and prospective study
Clinical and Translational Medicine,
Journal Year:
2025,
Volume and Issue:
15(4)
Published: April 1, 2025
Language: Английский
Diagnostic Accuracy of 3 Mpox Lateral Flow Assays for Antigen Detection, Democratic Republic of the Congo and United Kingdom
Elie Ishara-Nshombo,
No information about this author
Anushri Somasundaran,
No information about this author
Alessandra Romero-Ramirez
No information about this author
et al.
Emerging infectious diseases,
Journal Year:
2025,
Volume and Issue:
31(6)
Published: May 6, 2025
The
ongoing
outbreaks
of
mpox
highlight
the
urgent
need
for
a
rapid
and
low-cost
diagnostic
test
to
accurately
detect
control
this
emerging
disease.
We
estimated
analytical
sensitivity
using
viral
culture
monkeypox
virus
clade
IIb
lineage
clinical
performance
3
antigen
detection
tests
(Ag-RDT)
by
skin
swab
samples
upper-respiratory
from
patients
in
Democratic
Republic
Congo
United
Kingdom.
limit
was
1.0
×
104
plaque-forming
units/mL,
fulfilling
World
Health
Organization
recommendations.
Specificity
Ag-RDTs
100%,
but
at
0.00%-15.79%
0.00%
respiratory
samples.
None
reached
Organization's
target
sensitivity,
we
do
not
recommend
them
as
or
screening
tools
suspected
cases.
Accurate
diagnosis
remain
urgently
needed.
Language: Английский
Diagnostic accuracy of three mpox lateral flow assays for antigen detection in the Democratic Republic of Congo and the United Kingdom
Elie Ishara-Nshombo,
No information about this author
Anushri Somasundaran,
No information about this author
Alessandra Romero-Ramirez
No information about this author
et al.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 8, 2024
Summary
Background
The
ongoing
outbreaks
of
mpox,
the
disease
caused
by
monkeypox
virus
(MPXV)
highlight
urgent
need
for
a
rapid
and
low-cost
MPXV
diagnostic
test
to
accurately
detect
control
mpox
disease.
In
this
study
we
assessed
accuracy
three
brands
tests
antigen
detection
(Ag–RDT)
MPXV.
Methods
We
estimated
clinical
performance
FlowFlex
Monkeypox
Virus
Antigen
Rapid
Test
(ACON
Biotech
Co.,
Ltd.,
Hangzhou,
China),
Ecotest
(Assure
Tech.
Ltd,
STANDARD
Q
Ag
(SD
Biosensor,
Inc.
Republic
Korea)
using
skin
lesion
swabs
(SS)
upper–respiratory
tract
(URS)
from
68
participants
in
Democratic
Congo
(DRC)
16
United
Kingdom
(UK).
limit
(LOD)
Ag–RDT
was
evaluated
viral
culture
IIb
lineage
(EVAg,
France).
Findings
Although
specificity
high
(100%),
sensitivity
as
15·79%
(95%
CI,
5·52–37·57%)
Flowflex
10·53%
2·94–31·39%)
Standard–Q
SS
DRC.
0.00%
0·0–20·6%)
among
URS
UK,
Ag-RDT
0·0–12·7%)
0·0–21·5%).
LOD
all
determined
be
1·0×
10
4
pfu/ml
(1·3×10
5
copies/mL)
culture.
Interpretation
None
reached
target
thus
do
not
recommend
these
or
screening
tool
suspected
cases.
Marked
improvement
are
needed
prior
adoption.
recommended
analytical
WHO
product
profile
(TPP)
is
at
6
pfu/mL,
being
fulfilled
Ag–RDTs
suggesting
that
stated
TPP
does
align
with
desired
sensitivity.
There
remains
an
accurate
Ag-RDTs
diagnosis.
Language: Английский
Diagnostic Accuracy of Three Mpox Lateral Flow Assays for Antigen Detection in the Democratic Republic of Congo and the United Kingdom
Elie Ishara-Nshombo,
No information about this author
Anushri Somasundaran,
No information about this author
Alessandra Romero-Ramirez
No information about this author
et al.
Published: Jan. 1, 2024
Language: Английский
Diagnostic accuracy of polymerase chain reaction for detection of mpox in humans
G. Unnikrishnan,
No information about this author
Abhinav Singh,
No information about this author
Abhishek Purohit
No information about this author
et al.
Revista Panamericana de Salud Pública,
Journal Year:
2024,
Volume and Issue:
48, P. 1 - 1
Published: Dec. 4, 2024
To
evaluate
diagnostic
accuracy
of
polymerase
chain
reaction
(PCR)
in
detecting
mpox
infection
humans
by
pooling
the
estimates
sensitivity
and
specificity
across
different
study
settings.
Language: Английский
Enhancing Monkeypox Detection With Efficientnet-B5 And Image Augmentation Fusion Technique
Abdelrahman Omar Yusuf,
No information about this author
ABUBAKAR SADIQ ABDULLAHI,
No information about this author
M. Isah
No information about this author
et al.
International Journal of Scientific Research in Science and Technology,
Journal Year:
2024,
Volume and Issue:
11(6), P. 646 - 661
Published: Dec. 12, 2024
The
recent
surge
of
monkeypox
infections
worldwide
has
underscored
the
need
for
rapid,
accurate
diagnostic
tools,
particularly
in
regions
with
limited
access
to
laboratory-based
tests.
This
study
employs
deep
learning,
utilizing
a
pre-trained
efficientNet-B5
model
through
transfer
classify
from
digital
skin
lesion
images.
Data
was
compiled
Kaggle,
web
scraping,
and
hospital
records,
covering
both
similar
conditions
such
as
chickenpox,
measles
smallpox.
dataset
preprocessed
using
advanced
augmentation
fusion
techniques,
enhancing
image
diversity
maintaining
features
critical
model's
efficacy.
achieved
impressive
results,
demonstrating
99.47%
accuracy,
99.19%
precision
recall
99.72
monkeypox.
These
findings
suggest
that
model,
supported
by
fusion,
can
serve
reliable
tool
detecting
monkeypox,
providing
scalable
solution
early
identification
public
health
intervention
resource-constrained
settings.
Language: Английский