Rate of vertical transmission of coronavirus disease 2019 and effect of maternal vaccination: A prospective cohort study

Pediatrics International, Journal Year: 2025, Volume and Issue: 67(1)

Published: Jan. 1, 2025

Abstract Background We aimed to reveal the transmission rate of coronavirus disease 2019 (COVID‐19) and clinical features congenital neonatal COVID‐19 disclose efficacy maternally transferred antibodies by maternal vaccination against severe acute respiratory syndrome 2 (SARS‐CoV‐2). Methods This multicenter, prospective observational study included a comprehensive testing protocol with appropriate precautions. Mothers infants were enrolled classified into an active infection group (mothers at delivery), postinfection recovered from during pregnancy), vaccinated pregnancy). Specimen collections, polymerase chain reaction assays, anti‐SARS‐CoV‐2 antibody measurements, examinations conducted for 6 months delivery. Results Sixty‐nine mothers 70 enrolled. SARS‐CoV‐2 was detected in placenta 22% 21% group. Neither nor SARS‐CoV‐2‐specific IgM infants. No anomalies, functional disorders, or developmental problems observed months. Compared group, there significant increase titers according number vaccinations, which maintained longer than first month life. Conclusions Vertical not despite protocol. more often placenta, appeared prevent vertical transmission. Maternal increased considered immunologically efficient. Vaccination pregnancy is important preventing congenital, neonatal, infantile COVID‐19.

Language: Английский

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Long-Term Growth and Neurodevelopmental Outcomes of Neonates Infected with SARS-CoV-2 during the COVID-19 Pandemic at 18–24 Months Corrected Age: A Prospective Observational Study

Neonatology, Journal Year: 2024, Volume and Issue: 121(4), P. 450 - 459

Published: Jan. 1, 2024

<b><i>Introduction:</i></b> During the early coronavirus disease (COVID-19) pandemic in 2020, researchers cautioned about potential neuroinvasive capability of virus and long-term neurological consequences. Although a few preliminary studies have found delayed communication, fine motor, problem-solving skills infants after COVID-19 infection, there continues to be paucity data on development neonates diagnosed with COVID-19. <b><i>Methods:</i></b> We conducted prospective study 20 who acquired severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection during first wave (April–July 2020). At 18–24 months corrected age, we assessed neurodevelopment by Bayley Scales Infant Toddler Development, third edition (BSID-III), along growth, hearing, vision evaluation. <b><i>Results:</i></b> The mean age at assessment was 21 11 days ± 1 month 28 days. developmental delay nearly half children scores below one standard deviation either BSID-III domains. Mild cognitive, or language domains 9 (45%) moderate 2 (10%). Expressive language, receptive were predominantly affected. None had hearing impairment, blindness, significant growth faltering including clinically microcephaly. composite motor significantly lower those neurodevelopmental (<i>p</i> value – 0.02, 0.000, 0.03, respectively) without any differences their characteristics. <b><i>Conclusion:</i></b> Neonates infected SARS-CoV-2 an increased risk delays expressive age. severity is mild.

Language: Английский

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Evaluation of hearing screening results of newborns born to SARS-CoV-2 positive pregnant women

Northwestern Medical Journal, Journal Year: 2025, Volume and Issue: 5(1), P. 46 - 50

Published: Jan. 31, 2025

Aim: It is a scientific fact that certain viral infections during pregnancy cause hearing loss in newborns. The aim of this study was to investigate whether such are the congenital loss. This based on an examination screening newborns born pregnant women affected by current pandemic caused SARS-CoV-2 virus, which responsible for disease designated Coronavirus Disease 2019 (COVID-19). Materials and Methods: In retrospective case-control study, demographic data ABR test results total 81 were compared with those 101 healthy controls. mothers who tested positive polymerase chain reaction (PCR) between March September 2022. controls had no problems pregnancy. Results: prevalence PCR positivity 3.5%. A higher cesarean delivery rate observed group infection (p=0.028). failure initial both groups (22/81 vs. 25/101; p=0.712). However, subsequent analysis revealed there statistically significant difference secondary follow-up (p=0.926). Conclusion: suggest indication maternal neonatal

Language: Английский

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Updates on Auditory Outcomes of COVID-19 and Vaccine Side Effects: An Umbrella Review

Journal of Speech Language and Hearing Research, Journal Year: 2025, Volume and Issue: 68(3), P. 1311 - 1332

Published: Feb. 21, 2025

This umbrella review synthesizes and discusses systematic reviews (SRs) meta-analyses (MAs) on auditory outcomes associated with COVID-19 infection vaccination side effects. It is innovative in offering a comprehensive synthesis of evidence across adults infants while summarizing vaccine-related literature search followed the Preferred Reporting Items for Systematic Reviews Meta-Analyses 2020 guidelines, no restrictions population age or symptom severity. Four electronic databases were searched from their inception to October 2024. The Assessment Multiple 2 checklist Risk Bias tool used assess quality risk bias. identified 534 articles, narrowed down 14 SRs following full-text review: Nine focused COVID-19; two, born mothers infected during pregnancy; three, effects vaccination. A random-effects model revealed significantly high pooled estimates hearing loss (5.0%, 95% CI [1.0, 9.0], p < .012, three MAs, N = 21,932) tinnitus (13.5%, [5.9, 21.1], ≤ .001, four 36,236) adults. However, current nonhospitalized patients indicates that symptoms often improve after recovery. Studies also show low rate whose contracted pregnancy. Similarly, whereas has been linked tinnitus, these are rare, most experience improvement within weeks months. Evidence suggests adults, although remain rare newborns caution warranted due limitations variability studies.

Language: Английский

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Ear abnormalities in chronic fatigue syndrome (CFS), fibromyalgia (FM), Coronavirus-19 infectious disease (COVID) and long-COVID syndrome (PCS), sick-building syndrome (SBS), post-orthostatic tachycardia syndrome (PoTS), and autoimmune/inflammatory syndrome induced by adjuvants (ASIA): A systematic review

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: 23(10), P. 103606 - 103606

Published: Aug. 28, 2024

Language: Английский

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Auditory Screening in Newborns after Maternal SARS-CoV-2 Infection: An Overview

Children, Journal Year: 2023, Volume and Issue: 10(5), P. 834 - 834

Published: May 4, 2023

Background and aim: Several viruses have previously been reported to be responsible for congenital hearing loss; therefore, since the beginning of SARS-CoV-2 infection pandemic, various reports investigated a possible link. The aim this review is assess link between maternal COVID-19 loss. Methods: This systematic was performed using PRISMA criteria, searching Medline Embase databases from March 2020 February 2023. A total 924 candidate papers were identified; however, considering specific selection only nine selected additional analysis. Results: overall number children born mothers infected with during pregnancy identified through 1687. confirmed cases loss 0.7% (12/1688); description its nature (sensorineural vs. conductive) missing in studies, follow-up period variable across analyzed papers. Surprisingly, large proportion false positives recorded at first stage screening, which resulted normal re-test. Conclusions: Currently, correlation cannot definitively established. Further studies are desirable provide evidence on topic.

Language: Английский

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Neonatal COVID-19 treatment: Are there new chances?

Journal of Neonatal-Perinatal Medicine, Journal Year: 2024, Volume and Issue: 17(4), P. 501 - 507

Published: May 14, 2024

Coronavirus disease 2019 (COVID-19) is considered an infectious which caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Neonatal COVID-19 had been occurred in many countries would indicate the need of effective and safe treatment for these vulnerable group. In this study, we showed symptoms corona virus neonates, investigation neonates radiological features neonatal COVID-19. addition, discussed management COVI-19, antiviral treatment, monoclonal antibodies administration, immunomodulatory therapy, antibiotics, vitamins, minerals COVID-19, also telemedicine feeding newborn mother. We multisystem inflammatory (MIS-N), affected discussion complication further methods dealing research done on treatment.

Language: Английский

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Investigating the mode of transmission of COVID-19 through genital secretions, semen, the birth canal, and lactation: A systematic review

Journal of Education and Health Promotion, Journal Year: 2024, Volume and Issue: 13(1)

Published: July 1, 2024

In a global pandemic, the coronavirus has brought new challenges to reproductive and sexual health. This systematic review been conducted with aim of investigating a) transmission disease 2019 (COVID-19) through female-to-male secretions vice versa, b) vertical fetus, c) newborn birth canal, d) breast milk. this study, find related articles, databases were searched using English Persian keywords from beginning end 2023. Based on entry exit criteria qualitative evaluation studies based STROBE criterion, final summarized. According initial search, 5970 articles reviewed. After removing duplicate inappropriateness title, abstract article was not objectives project, there no relevant retrospective excluded. Finally, 120 selected as articles. The general results show that virus vagina blood fetus causing septicemia, mother water bag, genital secretions, ejaculate fluid are considered rare ruled out. Transmission rectal during anal or oral sex requires more extensive studies. It is possible transmit long-term impact COVID-19 systems women men unclear.

Language: Английский

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Risk of Hearing Loss in Neonates and Toddlers with in Utero Exposure to SARS‐CoV‐2

The Laryngoscope, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 4, 2024

Objective Given the prevalence of neonatal hearing loss (HL) associated with intrauterine viral exposures, goal this study is to provide information on HL in context COVID‐19 pandemic. Methods Data were drawn from Mother Baby Outcomes (COMBO) Initiative. 1007 participants completed newborn screen as part routine clinical care (COMBO‐EHR cohort) and 555 National Survey Children's Health (NSCH) at 2 and/or 3 years age for research purposes (COMBO‐RSCH cohort). Maternal SARS‐CoV‐2 infection status during pregnancy was determined through electronic health records maternal‐reported questionnaires. Results In adjusted multivariate logistic regression models covarying assessment, mode delivery, gestational there no significant association between exposure screening failure ( OR = 1.05, 95% CI 0.39–2.42, p 0.91) COMBO‐EHR cohort. COMBO‐RSCH cohort, similar non‐significant associations concern NSCH 1.19 [95% 0.30–4.24], 0.79). Conclusion There failed neonates. Similarly, based NSCH, toddlers. These results offer reassurance given widespread nature pandemic tens millions fetuses having a history exposure. Level Evidence 4 Laryngoscope , 2024

Language: Английский

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Is COVID-19 infection during pregnancy a risk for congenital hearing loss?

International Journal of Pediatric Otorhinolaryngology, Journal Year: 2024, Volume and Issue: 188, P. 112191 - 112191

Published: Dec. 9, 2024

Infections during pregnancy can increase the risk of congenital hearing loss. This population-based study investigated effect birthing parent COVID-19 infection on loss in infants.

Language: Английский

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