Exploring the JAK/STAT Signaling Pathway in Hepatocellular Carcinoma: Unraveling Signaling Complexity and Therapeutic Implications

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 13764 - 13764

Published: Sept. 6, 2023

Hepatocellular Carcinoma (HCC) continues to pose a substantial global health challenge due its high incidence and limited therapeutic options. In recent years, the Janus Kinase (JAK) Signal Transducer Activator of Transcription (STAT) pathway has emerged as critical signaling cascade in HCC pathogenesis. The review commences with an overview JAK/STAT pathway, delving into dynamic interplay between numerous upstream activators, such cytokines growth factors enriched pathogenic livers afflicted chronic inflammation cirrhosis. This paper also elucidates how persistent activation leads diverse oncogenic processes during hepatocarcinogenesis, including uncontrolled cell proliferation, evasion apoptosis, immune escape. context implications, this summarizes advancements targeting for treatment. Preclinical clinical studies investigating inhibitors modulators are discussed, highlighting their potential suppressing deadly disease. insights presented herein underscore necessity continued research promising avenue therapy.

Language: Английский

Harnessing Immunotherapy for Hepatocellular Carcinoma: Principles and Emerging Promises

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155928 - 155928

Published: March 1, 2025

Language: Английский

Dendritic Cell-Related Gene Signatures in Hepatocellular Carcinoma: An Analysis for Prognosis and Therapy Efficacy Evaluation

Journal of Hepatocellular Carcinoma, Journal Year: 2024, Volume and Issue: Volume 11, P. 1743 - 1761

Published: Sept. 1, 2024

This study aimed to identify dendritic cells (DCs) related genes in hepatocellular carcinoma (HCC) patients, establish DC-related subtypes and signatures, correlate them with prognosis treatment response.

Language: Английский