Unraveling lipid metabolism for acute myeloid leukemia therapy DOI Creative Commons
Cristiana O’Brien, Courtney L. Jones

Current Opinion in Hematology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Purpose of review The aim this is to highlight the importance lipids’ intricate and interwoven role in mediating diverse acute myeloid leukemia (AML) processes, as well potentially novel lipid targeting strategies. This will focus on new studies metabolism human leukemia, particularly highlighting work leukemic stem cells (LSCs), where lipids were assessed directly a metabolite. Recent findings Lipid essential support LSC function AML survival through mechanisms including supporting energy production, membrane composition, signaling pathways, ferroptosis. has highlighted rewiring metabolic plasticity which can underlie therapy response, impact cellular genetic heterogeneity metabolism, discovery noncanonical roles related proteins AML. Summary around clearly demonstrates their our understanding therapeutic We have only begun unravel regulation utilization disease. Further, layered dynamics homeostasis could provide opportunities target LSCs with potential improving outcomes for patients

Language: Английский

The Common Hallmarks of Aging, Circadian Rhythms and Cancer: Implications for Therapeutic Strategies DOI Creative Commons
Jie Wang, Fanglin Shao, Qingxin Yu

et al.

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.

Language: Английский

Citations

2
Role of the sulfur-containing amino acid-ROS axis in cancer chemotherapeutic drug resistance DOI
Bingli Wu, Yinwei Cheng, Liyan Li

et al.

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: unknown, P. 101238 - 101238

Published: March 1, 2025

Language: Английский

Citations

0
BMAL1-depletion remodels ceramide metabolism to regulate ferroptosis and sorafenib chemosensitivity in acute myeloid leukemia DOI Creative Commons

Hong Zheng,

Zhi Lin, Dan Wang

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(4), P. 112054 - 112054

Published: March 22, 2025

Language: Английский

Citations

0
Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis DOI Creative Commons
Rui Huang,

Dawei Chu,

Jiandang Shi

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 5, 2024

Osteosarcoma (OS) is a prevalent primary malignant bone tumor which lacks effective therapeutic interventions. Ferroptosis new form of programmed cell death characterized by iron-dependent accumulation lethal lipid oxidation, provides potential alternative intervene for the OS treatment. Shikonin major bioactive component extracted from roots lithospermum erythrorhizon also known as "Zicao" in traditional Chinese medicine, has been proved to have exhibits remarkable anti-tumor properties several cancers. However, whether ferroptosis participated shikonin mediated anti-OS activity still remains be clarified. Herein, we provide evidence that possesses capability induce ferroptosis, and elucidate underlying mechanisms treatment OS. In present study, it was found significantly suppressed cells proliferation blocked cycle progression

Language: Английский

Citations

1
Unraveling lipid metabolism for acute myeloid leukemia therapy DOI Creative Commons
Cristiana O’Brien, Courtney L. Jones

Current Opinion in Hematology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Purpose of review The aim this is to highlight the importance lipids’ intricate and interwoven role in mediating diverse acute myeloid leukemia (AML) processes, as well potentially novel lipid targeting strategies. This will focus on new studies metabolism human leukemia, particularly highlighting work leukemic stem cells (LSCs), where lipids were assessed directly a metabolite. Recent findings Lipid essential support LSC function AML survival through mechanisms including supporting energy production, membrane composition, signaling pathways, ferroptosis. has highlighted rewiring metabolic plasticity which can underlie therapy response, impact cellular genetic heterogeneity metabolism, discovery noncanonical roles related proteins AML. Summary around clearly demonstrates their our understanding therapeutic We have only begun unravel regulation utilization disease. Further, layered dynamics homeostasis could provide opportunities target LSCs with potential improving outcomes for patients

Language: Английский

Citations

0