Genes & Nutrition,
Journal Year:
2018,
Volume and Issue:
13(1)
Published: May 30, 2018
Biomarkers
of
food
intake
(BFIs)
are
a
promising
tool
for
limiting
misclassification
in
nutrition
research
where
more
subjective
dietary
assessment
instruments
used.
They
may
also
be
used
to
assess
compliance
guidelines
or
intervention.
therefore
hold
promise
direct
and
objective
measurement
intake.
However,
the
number
comprehensively
validated
biomarkers
is
limited
just
few.
Many
new
candidate
emerge
from
metabolic
profiling
studies
advances
chemistry.
Furthermore,
identified
based
on
extensive
literature
reviews
such
as
described
Biomarker
Food
Intake
Reviews
(BFIRev).
To
systematically
critically
validity
intake,
it
necessary
outline
streamline
an
optimal
reproducible
validation
process.
A
consensus-based
procedure
was
provide
evaluate
set
most
important
criteria
systematic
BFIs.
As
result,
developed
including
eight
criteria,
plausibility,
dose-response,
time-response,
robustness,
reliability,
stability,
analytical
performance,
inter-laboratory
reproducibility.
The
has
dual
purpose:
(1)
estimate
current
level
approach
(2)
pinpoint
which
additional
needed
full
each
biomarker
This
position
paper
outlines
second
step
BFIRev
but
identified,
e.g.,
metabolomic
studies.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2019,
Volume and Issue:
2019, P. 1 - 11
Published: June 16, 2019
Although
some
polyphenol
biomarkers
in
serum
or
urine
have
been
identified
by
untargeted
metabolomics
and
proved
to
reflect
dietary
intake,
only
a
few
of
them
validated
different
studies
populations
with
simple
reliable
targeted
methods.
In
the
present
study,
method
LC/MS/MS
for
measurement
twenty-two
samples
was
established
effectively
assess
habitual
intake
free-living
healthy
Chinese
subjects.
Multivariate
logistic
regression
models
were
used
relationships
overweight
obesity
after
adjusting
potential
confounders.
The
levels
urinary
biomarkers,
especially
gut
microbial
metabolites
polyphenols,
inversely
associated
obesity,
this
association
more
pronounced
inflammatory
groups,
suggesting
that
it
is
great
importance
maintain
at
high
intake-sufficient
polyphenols
chronic
inflammation
than
others.
these
may
offer
valid
alternative
complementary
addition
self-reported
survey
evaluation
investigation
into
their
disease-related
endpoints
large-scale
clinical
epidemiologic
studies.
BMJ,
Journal Year:
2020,
Volume and Issue:
unknown, P. m2194 - m2194
Published: July 8, 2020
Abstract
Objective
To
investigate
the
association
of
plasma
vitamin
C
and
carotenoids,
as
indicators
fruit
vegetable
intake,
with
risk
type
2
diabetes.
Design
Prospective
case-cohort
study.
Setting
Populations
from
eight
European
countries.
Participants
9754
participants
incident
diabetes,
a
subcohort
13
662
individuals
Investigation
into
Cancer
Nutrition
(EPIC)
cohort
340
234
participants:
EPIC-InterAct
Main
outcome
measure
Incident
Results
In
multivariable
adjusted
model,
higher
was
associated
lower
developing
diabetes
(hazard
ratio
per
standard
deviation
0.82,
95%
confidence
interval
0.76
to
0.89).
A
similar
inverse
shown
for
total
carotenoids
0.75,
0.68
0.82).
composite
biomarker
score
(split
five
equal
groups),
comprising
individual
inversely
hazard
ratios
0.77,
0.66,
0.59,
0.50
groups
2-5
compared
group
1
(the
lowest
group).
Self-reported
median
intake
274
g/day,
396
508
g/day
in
categories
defined
by
1,
3,
5
score,
respectively.
One
difference
equivalent
66
(95%
61
71)
0.75
(0.67
0.83).
This
would
be
an
absolute
reduction
0.95
1000
person
years
follow
up
if
achieved
across
entire
population
characteristics
countries
included
this
analysis.
Conclusions
These
findings
indicate
between
C,
their
different
biomarkers
are
objective
consumption,
suggest
that
diets
rich
even
modestly
consumption
could
help
prevent
development
OMICS A Journal of Integrative Biology,
Journal Year:
2008,
Volume and Issue:
13(1), P. 69 - 80
Published: Aug. 7, 2008
Abstract
Taste
perception
plays
a
key
role
in
determining
individual
food
preferences
and
dietary
habits.
Individual
differences
bitter,
sweet,
umami,
sour,
or
salty
taste
may
influence
habits,
affecting
nutritional
status
nutrition-related
chronic
disease
risk.
In
addition
to
these
traditional
modalities
there
is
growing
evidence
that
"fat
taste"
represent
sixth
modality.
Several
receptors
have
been
identified
within
cell
membranes
on
the
surface
of
tongue,
they
include
T2R
family
bitter
receptors,
T1R
associated
with
sweet
umami
perception,
ion
channels
PKD1L3
PKD2L1
linked
sour
taste,
integral
membrane
protein
CD36,
which
putative
receptor.
Additionally,
epithelial
sodium
vanilloid
receptor,
TRPV1,
account
for
perception.
Common
polymorphisms
genes
involved
some
interindividual
habits
between
populations.
This
variability
could
affect
choices
health
risk
disease.
review
will
summarize
present
state
knowledge
genetic
variation
how
such
might
intake
behaviors.
Journal of Proteome Research,
Journal Year:
2013,
Volume and Issue:
12(4), P. 1645 - 1659
Published: Feb. 20, 2013
Elucidation
of
the
relationships
between
genotype,
diet,
and
health
requires
accurate
dietary
assessment.
In
intervention
epidemiological
studies,
assessment
usually
relies
on
questionnaires,
which
are
susceptible
to
recall
bias.
An
alternative
approach
is
quantify
biomarkers
intake
in
biofluids,
but
few
such
markers
have
been
validated
so
far.
Here
we
describe
use
metabolomics
for
discovery
nutritional
biomarkers,
using
citrus
fruits
as
a
case
study.
Three
study
designs
were
compared.
Urinary
metabolomes
profiled
volunteers
that
had
(a)
consumed
an
acute
dose
orange
or
grapefruit
juice,
(b)
juice
regularly
one
month,
(c)
reported
high
low
consumption
products
large
cohort
Some
signals
found
reflect
all
three
studies.
Proline
betaine
flavanone
glucuronides
identified
known
various
other
revealed.
Further,
many
increased
after
not
sensitive
enough
discriminate
consumers
We
propose
urine
profiling
subjects
stratified
by
effective
strategy
wide
range
foods.
Annual Review of Nutrition,
Journal Year:
2015,
Volume and Issue:
35(1), P. 565 - 594
Published: June 6, 2015
Diet
is
a
leading
modifiable
risk
factor
for
chronic
disease,
but
it
remains
difficult
to
measure
accurately
due
the
error
and
bias
inherent
in
self-reported
methods
of
diet
assessment.
Consequently,
there
pressing
need
more
objective
biomarkers
use
health
research.
The
stable
isotope
ratios
light
elements
are
promising
set
candidate
because
they
vary
naturally
reproducibly
among
foods,
those
variations
captured
molecules
tissues
with
high
fidelity.
Recent
studies
have
identified
valid
isotopic
measures
short-
long-term
sugar
intake,
meat
fish
intake
specific
populations.
These
provide
strong
foundation
validating
general
US
population.
Approaches
improve
specificity
foods
needed;
example,
by
modeling
using
multiple
or
isolating
measuring
linked
interest.
