Frequency and risk factors of psychological distress among individuals with epilepsy before and during the outbreak of the SARS-CoV-2 Omicron variant in China: an online questionnaire survey

Acta Epileptologica, Journal Year: 2024, Volume and Issue: 6(1)

Published: Jan. 15, 2024

Abstract Background The COVID-19 pandemic substantially increases the risk of severe psychological distress among people with epilepsy (PWE), especially those monthly household income < 5000 RMB or uncontrolled seizures. Patients Kessler scores > 12 should consult a psychiatrist, during major disasters. This study was aimed to compare frequency Chinese PWE before and outbreak SARS-CoV-2 Omicron variant, identify factors for such distress. Methods In this prospective study, we collected sociodemographic data aged 14 years, who were treated at our center December 1 15, 2022. All participants completed 6-item Psychological Distress Scale again outbreak. Health visitors unrelated patients included as control. Multivariate logistic regression analysis performed its exacerbation. Results Of 223 PWE, 127 tested positive SARS-CoV-2, while 174 218 controls SARS-CoV-2. neurological symptoms similar between average score significantly higher than it (9.93 ± 3.98 vs. 8.52 0.23, P 0.001). (5.146 0.35, 0.001) lower that PWE. We identified three independent predictors in outbreak, i.e., (OR = 0.252, 95%CI 0.064–0.998, 0.048), 0.067, 0.026–0.174, 0.001), seizure onset within 30 days assessment 0.356, 0.157–0.805, 0.013). predictors, last one also an predictor exacerbation 0.302, 0.123–0.741, 0.009). Conclusions Our suggests has increased individuals epilepsy, regardless viral infection not. Various “long COVID” appeared first time these highlighting need clinicians screen carefully condition. Management disaster focus on control seizures maintenance mental health, incomes below RMB, suffering having history

Language: Английский

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Possibility of correction of cerebral blood flow disorders and central nervous system damage with citicoline in patients with coronary artery disease in combination with COVID-19

Infusion & Chemotherapy, Journal Year: 2024, Volume and Issue: 1, P. 51 - 57

Published: March 27, 2024

ABSTRACT. The review describes some pathogenetic mechanisms of central nervous system lesions in patients with coronary artery disease combination coronavirus (COVID-19) and presents the current possibilities their pharmacotherapy. analysis experimental clinical trials has shown that multifactorial effect citicoline on main pathogenic links brain damage COVID-19 numerous positive effects make it a promising drug treatment post-COVID syndrome.

Language: Английский

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SARS-CoV-2 Nucleocapsid Protein Induces Tau Pathological Changes That Can Be Counteracted by SUMO2

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7169 - 7169

Published: June 28, 2024

Neurologic manifestations are an immediate consequence of SARS-CoV-2 infection, the etiologic agent COVID-19, which, however, may also trigger long-term neurological effects. Notably, COVID-19 patients with symptoms show elevated levels biomarkers associated brain injury, including Tau proteins linked to Alzheimer's pathology. Studies in organoids revealed that alters phosphorylation and distribution infected neurons, but mechanisms currently unknown. We hypothesize these pathological changes due recruitment into stress granules (SGs) operated by nucleocapsid protein (NCAP) SARS-CoV-2. To test this hypothesis, we investigated whether NCAP interacts localizes SGs hippocampal neurons vitro vivo. Mechanistically, tested SUMOylation, a posttranslational modification Tau, modulates their interaction. found colocalize physically interact. induces hyperphosphorylation causes cognitive impairment mice hippocampus. Finally, SUMOylation SG formation performance mice. Our data demonstrate both Moreover, SUMO2 ameliorates NCAP-induced pathology, highlighting importance pathway as target intervention against neurotoxic insults, such oligomers viral infection.

Language: Английский

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Post-Acute COVID-19 Syndrome and Stroke

JOURNAL OF SURGICAL AND CLINICAL RESEARCH, Journal Year: 2024, Volume and Issue: 15(1), P. 44 - 58

Published: July 8, 2024

This review explores the multifaceted strategies to mitigate risk of cerebrovascular impairment in young adults recovering from COVID-19. The pandemic has illuminated an increased incidence stroke populations traditionally considered at lower risk, underscoring need for targeted preventative measures. Given complex interplay between SARS-CoV-2 infection and this article synthesizes current evidence recommendations across lifestyle modifications, medical interventions, proactive health monitoring. Key include adopting a heart-healthy diet, engaging regular physical activity, implementing stress reduction techniques. management existing cardiovascular factors, such as hypertension diabetes, is emphasized crucial minimizing post-COVID. Moreover, education on recognizing symptoms vital ensuring timely response. also discusses importance avoiding smoking, limiting alcohol intake, and, specific high-risk individuals, judicious use anticoagulants. Regular follow-ups monitoring post-COVID addressing any ongoing complications are advocated identify manage potential risks early. In conclusion, comprehensive approach involving changes, vigilant pre-existing conditions, symptoms, healthcare engagement essential reducing events underscores continued research public advocacy long-term effects health.

Language: Английский

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SARS-COV-2 and Brain Disease

Published: June 12, 2024

Severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) primarily affects the lungs and causes distress, but also all other tissues, especially brain heart. COVID-19 has caused devastation, maiming killing millions of people worldwide. It is crucial to elucidate factors involved in development this pandemic prevent emergence similar pandemics coming years. Analysing transmission routes, mechanism action, treatment approaches prognostic SARS-CoV-2 imperative for future humanity. Patients may experience neurological symptoms such as anosmia, wetusia, encephalopathy, meningitis cerebral vascular events. Almost every symptom related nervous system can be seen patients. In article, I aimed explain effects light literature.

Language: Английский

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Brain Mechanisms Involved in Post COVID Syndrome: A Narrative Review

Neurochemical Journal, Journal Year: 2024, Volume and Issue: 18(3), P. 397 - 405

Published: Sept. 1, 2024

Language: Английский

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INTRACARDIAC HEMODYNAMICS, CEREBRAL BLOOD FLOW AND MICROEMBOLIC SIGNAL BURDEN IN STABLE CORONARY ARTERY DISEASE PATIENTS WITH CONCOMITANT COVID-19

Wiadomości Lekarskie, Journal Year: 2023, Volume and Issue: 76(5), P. 1205 - 1215

Published: Jan. 1, 2023

The aim: To estimate the changes in intracardiac hemodynamics, cerebral blood flow (CBF), and microembolic signals` (MES) burden stable coronary artery disease (SCAD) patients with concomitant COVID-19.Materials methods: cross-sectional study analyzed data from 80 patients, being subdivided as follows: group 1 (G1) - SCAD without COVID-19 (n=30); 2 (G2) (n=25); 3 (G3) (n=25). control (CG) included 30 relatively healthy volunteers. CBF total MES count were assessed by transcranial Doppler ultrasound.Results: Transthoracic echocardiography G2 revealed most pronounced left ventricular (LV) dilation its contractility decline (the rise of end-systolic volume (ESV) ejection fraction decrease), compared to G1 G3. G1-G3 (vs. CG) presented lower peak systolic velocities all studied intracranial arteries (middle posterior bilaterally, basilar artery), along higher count. Such a drop was G2. Both G3 demonstrated highest amount MES, slightly We built linear neural network, discriminating pattern both LV ESV count, inherent G2.Conclusions: function impairment, increase, more advanced contrast decrease associated load case constellation.

Language: Английский

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Editorial for the Neurogenetics and Neurogenomics special issue

Human Genetics, Journal Year: 2023, Volume and Issue: 142(8), P. 997 - 999

Published: July 21, 2023

Language: Английский

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