Luteolin Relieves Metabolic Dysfunction-Associated Fatty Liver Disease Caused by a High-Fat Diet in Rats Through Modulating the AdipoR1/AMPK/PPARγ Signaling Pathway DOI Open Access

Pongsakorn Taweesap,

Prapassorn Potue, Juthamas Khamseekaew

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3804 - 3804

Published: April 17, 2025

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a significant global public health issue. Luteolin possesses several beneficial biological properties, including antioxidation and anti-inflammation. This study investigated luteolin’s effect potential mechanisms on MAFLD in high-fat diet (HFD)-fed rats. Rats were administered an HFD supplemented with fructose for 12 weeks to induce MAFLD. After that, the HFD-fed rats given either luteolin (50 or 100 mg/kg/day) metformin (100 4 weeks. improved metabolic parameters induced by HFD, since it decreased body weight, blood pressure, fasting glucose, serum insulin, free acids, cholesterol, triglyceride levels (p < 0.05). reduced hepatic injury inflammatory markers Additionally, treated showed malondialdehyde raised catalase activity plasma attenuated steatosis compared untreated also increased adiponectin accompanied upregulation of receptor 1 (AdipoR1), AMP-activated protein kinase (AMPK), peroxisome proliferator-activated γ (PPAR-γ) expression These findings revealed that ameliorated HFD-induced rats, possibly reducing alterations oxidative stress restoring AdipoR1, AMPK, PPARγ

Language: Английский

Stimulation of Auricular Vagus Nerve Ameliorates Chronic Stress induced Metabolic Syndrome via Activation of Sirtuin-6 DOI
Arjun Singh Kaushik, Vipul Agarwal, Neeraj Kumar

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 756, P. 151567 - 151567

Published: March 5, 2025

Language: Английский

Citations

1
Luteolin Relieves Metabolic Dysfunction-Associated Fatty Liver Disease Caused by a High-Fat Diet in Rats Through Modulating the AdipoR1/AMPK/PPARγ Signaling Pathway DOI Open Access

Pongsakorn Taweesap,

Prapassorn Potue, Juthamas Khamseekaew

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3804 - 3804

Published: April 17, 2025

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a significant global public health issue. Luteolin possesses several beneficial biological properties, including antioxidation and anti-inflammation. This study investigated luteolin’s effect potential mechanisms on MAFLD in high-fat diet (HFD)-fed rats. Rats were administered an HFD supplemented with fructose for 12 weeks to induce MAFLD. After that, the HFD-fed rats given either luteolin (50 or 100 mg/kg/day) metformin (100 4 weeks. improved metabolic parameters induced by HFD, since it decreased body weight, blood pressure, fasting glucose, serum insulin, free acids, cholesterol, triglyceride levels (p < 0.05). reduced hepatic injury inflammatory markers Additionally, treated showed malondialdehyde raised catalase activity plasma attenuated steatosis compared untreated also increased adiponectin accompanied upregulation of receptor 1 (AdipoR1), AMP-activated protein kinase (AMPK), peroxisome proliferator-activated γ (PPAR-γ) expression These findings revealed that ameliorated HFD-induced rats, possibly reducing alterations oxidative stress restoring AdipoR1, AMPK, PPARγ

Language: Английский

Citations

0