Nomogram for predicting post-progression-free survival in patients with recurrent pancreatic ductal adenocarcinoma after radical surgery: a retrospective analysis DOI Creative Commons
Dailei Qin, Pu Xi, Kewei Huang

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 6, 2024

Background Radical resection is the only curative method for patients with pancreatic adenocarcinoma (PDAC). However, nearly 85% of PDAC suffer from local or distant recurrence within 5 years after resection. The progression recurrent lesions accelerates mortality rate in patients. influence clinicopathological factors on post-progression-free survival (PPFS), defined as period tumor to timing lesions, has rarely been discussed. present study aimed explore independent prognostic PPFS and construct a nomogram prediction. Materials methods 200 were divided into training validation groups by leave-one-out cross-validation. patients’ characteristics compared through chi-square test. Meanwhile, these enrolled univariate multivariate COX regression find PPFS. Moreover, Kaplan–Meier analysis based was performed. Finally, we constructed model prediction, followed an effectiveness examination. Results who received multi-agent chemotherapy surgery showed longer than single-agent group. similar Local metastases, early recurrence, lympho-vascular invasion, higher T stage, N stage predicted shorter indicate constructed. Conclusion Multi-agent recommended surgery. also deserves consideration recurrence. could be used

Language: Английский

Predictive role of the prognostic nutritional index for long-term prognosis among patients undergoing pancreatoduodenectomy: a meta-analysis DOI Creative Commons
Ying Liu, Keyu Li

BMC Surgery, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 29, 2025

To identify the predictive role of preoperative prognostic nutritional index (PNI) for long-term survival in patients undergoing pancreatoduodenectomy. The PubMed, EMBASE, Web Science, Cochrane Library and CNKI databases were searched up to October 28, 2024. primary outcomes included overall (OS) disease-free (DFS). Hazard ratios (HRs) with 95% confidence intervals (CIs) calculated, subgroup analyses by country, type cancer source HR performed. Fifteen studies 2106 included. pooled results demonstrated that a lower PNI was related poorer OS (HR = 1.60, CI: 1.38-1.86, P < 0.001) DFS 1.44, 1.00-2.07, 0.051). Subgroup analysis stratified country (China vs. non-China), (pancreatic nonpancreatic mixed) (univariate multivariate analysis) revealed similar results. On basis available evidence, might serve as novel indicator pancreatoduodenectomy, predicting worse survival. However, more high-quality are needed further verify above findings.

Language: Английский

Citations

0
Comparing the operative, oncological, post-operative outcomes and complications of robotic and laparoscopic pancreaticoduodenectomy for the treatment of pancreatic and periampullary cancers: a systematic review and meta-analysis with subgroup analysis DOI
Konstantinos Kossenas,

Riad Kouzeiha,

Olga Moutzouri

et al.

Journal of Robotic Surgery, Journal Year: 2025, Volume and Issue: 19(1)

Published: March 5, 2025

Language: Английский

Citations

0
Nomogram for predicting post-progression-free survival in patients with recurrent pancreatic ductal adenocarcinoma after radical surgery: a retrospective analysis DOI Creative Commons
Dailei Qin, Pu Xi, Kewei Huang

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 6, 2024

Background Radical resection is the only curative method for patients with pancreatic adenocarcinoma (PDAC). However, nearly 85% of PDAC suffer from local or distant recurrence within 5 years after resection. The progression recurrent lesions accelerates mortality rate in patients. influence clinicopathological factors on post-progression-free survival (PPFS), defined as period tumor to timing lesions, has rarely been discussed. present study aimed explore independent prognostic PPFS and construct a nomogram prediction. Materials methods 200 were divided into training validation groups by leave-one-out cross-validation. patients’ characteristics compared through chi-square test. Meanwhile, these enrolled univariate multivariate COX regression find PPFS. Moreover, Kaplan–Meier analysis based was performed. Finally, we constructed model prediction, followed an effectiveness examination. Results who received multi-agent chemotherapy surgery showed longer than single-agent group. similar Local metastases, early recurrence, lympho-vascular invasion, higher T stage, N stage predicted shorter indicate constructed. Conclusion Multi-agent recommended surgery. also deserves consideration recurrence. could be used

Language: Английский

Citations

0