Effects of Maternal Stress on the Development of the Somatotropic Axis During the Larval and Juvenile Stages in Zebrafish (Danio rerio)
Fishes,
Journal Year:
2025,
Volume and Issue:
10(2), P. 37 - 37
Published: Jan. 21, 2025
Stress
is
recognized
as
an
adaptive
response
to
potentially
harmful
environmental
stimuli.
The
primary
physiological
adaptation
stress
increase
in
circulating
cortisol
levels,
which,
excess,
can
be
transferred
and
incorporated
into
the
oocytes
of
maturing
females,
affecting
embryonic
developmental
program.
Additionally,
maternal
energy
availability
essential
factor
that
modulates
this
Based
on
background,
we
investigated
effects
development
somatotropic
axis
zebrafish
offspring
juveniles.
Zebrafish
mothers
were
divided
two
groups
based
diet:
Group
1
received
a
cortisol-enriched
diet,
mimic
stress,
while
2
(control)
standard
for
five
days.
On
third
day
after
treatment,
control
treated
females
bred
with
untreated
males.
Offspring
assessed
at
0,
24,
48,
72,
96,
120,
144
h
post-fertilization
(hpf).
Morphological
analyses
performed
during
development,
including
survival
rate,
body
length,
presence
pericardial
edema,
heartbeat.
We
examined
gene
expression
key
components,
mtor,
foxo3a,
mafbx,
murf1,
mstna,
gh,
igf1,
igf2a,
igf2b,
11hsdb2,
fkbp5.
study
demonstrated
cortisol-treated
significantly
influenced
resulting
higher
mortality
rates
increased
morphological
abnormalities,
particularly
edema.
Gene
analysis
revealed
alterations
transcripts
related
axis,
especially
genes
involved
protein
synthesis,
signs
accelerated
growth
first
hour
post-fertilization.
At
30
days
post-fertilization,
juveniles
from
displayed
marked
muscle
bundle
size
cross-sectional
diameter
compared
group.
Our
findings
provide
valuable
insights
intricate
interaction
between
factors
offspring.
Language: Английский
Endocrine Parameters and Climate Change
Endocrines,
Journal Year:
2025,
Volume and Issue:
6(1), P. 5 - 5
Published: Feb. 7, 2025
The
endocrine
system
relies
on
complex
cell
signaling
and
epigenetic
processes
to
adjust
the
body’s
needs.
However,
stressors
such
as
climate
change
heat
can
disrupt
system.
This
study
aims
collect
systematically
review
evidence
from
publications
exploring
how
impacts
laboratory
parameters.
process
included
developing
research
questions,
defining
inclusion
exclusion
criteria,
conducting
database
searches,
screening
selecting
relevant
publications,
collecting
analyzing
data,
interpreting
findings,
drawing
conclusions.
identified
multiple
parameters
linked
mechanisms
by
which
various
function.
Climate
change,
especially
stress,
affects
production
levels
of
key
hormones.
underlying
disruption
hormones
are
also
explored
in
this
paper.
provides
a
clear
overview
influences
outlines
stress-triggered
disruption.
Language: Английский