KET or ECT for treatment-resistant depression?

International Journal of Psychiatry in Clinical Practice, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 3

Published: Feb. 10, 2025

Modern electroconvulsive therapy (ECT) and ketamine currently represent the most effective treatment options in depressed patients showing non-response to two or more trials of antidepressants. Recently, large sample head-to-head comparisons intravenous versus ECT for treatment-resistant depression (TRD) have fuelled debate on which might be effective. However, informative value these studies is limited due major methodological differences, especially regarding patients' baseline clinical characteristics procedures. This commentary, reaction recently published article by Jha et al. 'Ketamine vs Electroconvulsive Therapy Treatment-Resistant Depression: A Secondary Analysis a Randomized Clinical Trial' JAMA Network Open, addresses this issue proposes that decisions should based substantiated, predictive response markers patient's preferences. It undisputed both treatments are highly TRD, yet, given usually administered before ECT, efficacy non-responders urgently warranted.KEYPOINTSModern depressionHead-to-head yielded incongruent findings differing proceduresTreatment-decisions preferences while considering specific side effect profiles optionsFuture prospective assess non-responders.

Language: Английский

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Integrating the lactulose-mannitol test for intestinal permeability with untargeted metabolomics for drug monitoring through dual liquid chromatography-mass spectrometry

Analytical and Bioanalytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

In this study, we developed a customized high-resolution mass spectrometry metabolomics workflow integrating the dual sugar test employing lactulose and mannitol as probes for intestinal permeability assessment with untargeted screening of small molecules. Urine samples were collected from patients major depression healthy controls part clinical study at psychiatric department. Using injection/dual chromatography setup, quantified by hydrophilic interaction liquid (HILIC) in targeted assay, while drugs their metabolites profiled an manner reversed-phase separation. Rigorous method development validation allowed selective separation isomers consequently accurate quantification urine. Internal standardization compound specific stable isotope-labeled standards enabled excellent analytical figures merit such high recoveries, precision (< 5%), working range (5 orders magnitude). Within one run, was assessed together metabolites, allowing to screen confounding patient compliance therapeutic scheme.

Language: Английский

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Combination of ketamine and electroconvulsive therapy in treatment resistant depression

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Restoration of mitochondrial energy metabolism by electroconvulsive therapy in adolescent and juvenile mice

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: April 10, 2025

Adolescent depression is an increasingly serious public health issue, and traditional treatment methods often have side effects or limited efficacy. Electroconvulsive therapy (ECT), a widely used for severe depression, has recently gained attention its potential in treating adolescent depression. Previous studies suggest that mitochondrial dysfunction closely related to the onset of Therefore, investigating mechanism by which ECT alleviates depressive symptoms through improvement energy metabolism great significance. This study employed chronic unpredictable mild stress (CUMS) mouse model assess on depression-like behaviors sucrose preference test, open field tail suspension test. Additionally, markers, including ATP levels, oxygen consumption rate (OCR), lactate, pyruvate, were measured both human plasma evaluate function. The results showed significantly improved anxiety-like mice, as evidenced reversal abnormal Analysis markers revealed increased restored OCR, reduced lactate accumulation, pyruvate levels. These findings restoring improving brain supply. systematically explored metabolism. indicate not only effectively but also provides new insights experimental evidence function restoration. Future research could further investigate how combine drug treatments enhance function, improve efficacy, different subtypes, providing guidance personalized clinical treatment.

Language: Английский

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Clinical efficacy of electroconvulsive therapy combined with antidepressant medication in patients with treatment-resistant depression: A meta-analysis

The International Journal of Psychiatry in Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Objective To systematically evaluate the efficacy of electroconvulsive therapy (ECT) combined with antidepressant medication in patients treatment-resistant depression. Methods A search CNKI, Wanfang, Vip, China Biomedical Literature Database, PubMed, Cochrane Library, Embase, and Web Science databases was conducted from their inception to January 1, 2025. Randomized controlled trials evaluating ECT depression were included. The experimental group received drugs, while control either alone or a placebo. Data analyzed using RevMan 5.2 software. Results total 11 randomized involving 1254 included analysis. Patients treated antidepressants showed significantly greater improvement depressive symptoms ( SMD = −0.29, 95% CI −0.47 −0.12, P 0.001) higher remission rates OR 1.73, 1.24 2.40, 0. 001) compared alone. There no significant difference between two groups seizure duration 0.17, −0.14 0.49, 0.28) incidence adverse effects 1.15, 0.73 21.82, 0.54). Conclusion combination modestly improves increases Additionally, it shows reactions alone, suggesting its comparable safety profile.

Language: Английский

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