The Role Of Cytokines In Irritable Bowel Syndrome: Review Article

INTERNATIONAL JOURNAL OF HEALTH & MEDICAL RESEARCH, Journal Year: 2024, Volume and Issue: 03(05)

Published: May 25, 2024

(IBS) or Irritable bowel syndrome is a complicated health condition with different causative factors, including inflammation and infection, that have recently acquired as significant triggers of IBS. Inflammatory response might serve critical pathway in the progression IBS, beside inequality cytokines within plasma and/or intestinal mucosal lining. Many biomarkers been associated to possible mechanisms underlying IBS are used make differentiation between non-IBS subjects. Incorporation these into routine clinical work important for fast accurate diagnosis effective treatment. Because patients often experience ambiguous overlapping symptoms, creation precise could significantly enhance both patient care. This review examines treatment Classifying either pro-inflammatory anti-inflammatory understanding their involvement development irritable syndrome.

Language: Английский

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Molecular Morbidity Score–Can MicroRNAs Assess the Burden of Disease?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8042 - 8042

Published: July 24, 2024

Multimorbidity refers to the presence of two or more chronic diseases and is associated with adverse outcomes for patients. Factors such as an ageing population have contributed a rise in prevalence multimorbidity globally; however, often neglected clinical guidelines. This largely because patients are systematically excluded from trials. Accordingly, there urgent need develop novel biomarkers methods prognostication this cohort The hallmarks now thought potentiate pathogenesis multimorbidity. MicroRNAs small, regulatory, noncoding RNAs which been implicated numerous diseases; substantial body evidence implicating microRNA dysregulation different aetiology diseases. article proposes using framework panel microRNAs assess prognostic burden putative molecular morbidity score would many potential applications, including assessing efficacy interventions, informing decision making facilitating wider inclusion

Language: Английский

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Recent studies on gut-brain axis and irritable bowel syndrome

Shijie huaren xiaohua zazhi, Journal Year: 2024, Volume and Issue: 32(7), P. 468 - 483

Published: July 28, 2024

Language: Английский

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Transcriptomic Module Discovery of Diarrhea-Predominant Irritable Bowel Syndrome: A Causal Network Inference Approach

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9322 - 9322

Published: Aug. 28, 2024

Irritable bowel syndrome with diarrhea (IBS-D) is the most prevalent subtype of IBS, characterized by chronic gastrointestinal symptoms in absence identifiable pathological findings. This study aims to investigate molecular mechanisms underlying IBS-D using transcriptomic data. By employing causal network inference methods, we identify key modules associated IBS-D. Utilizing data from public databases and applying advanced computational techniques, uncover potential biomarkers therapeutic targets. Our analysis reveals significant alterations that affect cellular functions, offering new insights into complex pathophysiology These findings enhance our understanding disease may foster development more effective treatments.

Language: Английский

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Effect of Tryptophan Restriction in the Therapy of Irritable Bowel Syndrome: a Systematic Review

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 4141 - 4151

Published: Sept. 1, 2024

The metabolic pathways of tryptophan (TRP) have been implicated in the pathophysiology irritable bowel syndrome (IBS), positing that strategic modulation TRP consumption may exert regulatory effects on serotonin levels, consequently altering clinical manifestation IBS. This systematic review was meticulously orchestrated to evaluate effect restriction

Language: Английский

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