Ameliorative Effect of SR48692 on the Testicular and Epididymal Impairments of High-Fat Diet- Induced Swiss Albino Mice DOI

Pradeep Verma,

Himanshu Pal,

Banalata Mohanty

et al.

Toxicology International, Journal Year: 2024, Volume and Issue: unknown, P. 435 - 442

Published: July 24, 2024

This study investigated the role of Neurotensin (NT) receptor-1 antagonist SR48692 on High-Fat Diet (HFD)-induced considerable morphological alterations in testis and epididymis mice. Excessive intake fat a sedentary lifestyle are major causes metabolic comorbidities current obesogenic environment. Consumption HFD induces NT release gut, which promotes lipid absorption. Elevated is associated with imbalanced energy status could be responsible for negative impact reproductive outcomes. Male mice (n = 24) were randomly assigned, based diet into Control (CD) 4 weeks; they further divided 2 subgroups administered saline (100 μg/kg b.w.) intraperitoneally next weeks. The present findings revealed that HFD-induced obesity caused significant circulating hormone profiles leading to deterioration testicular epididymal histoarchitechture. However, co-treatment has significantly restored detrimental effect profiles, justified by improvements histoarchitechture epididymis. only group showed adverse effects studied parameters. results reported herein have efficacy actively overcome effects. Therefore, might considered therapeutic HFDinduced impairments.

Language: Английский

Neurotensin via Type I Receptor Modulates the Endotoxemia Induced Oxido-Inflammatory Stress on the Sympathetic Adrenomedullary System of Mice Regulating NF-κβ/Nor-Epinephrine Pathway DOI
Aparna Tiwari,

Banalata Mohanty

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

Citations

0
Efficacy of the neurotensin receptor 1 analog PD149163 in modulation of the kidney inflammation: Inhibition of the nuclear factor kappa β signaling pathway and oxidative stress in endotoxemic mice DOI

Swarnima Mishra,

S.N. Srivastava,

Banalata Mohanty

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177398 - 177398

Published: Feb. 1, 2025

Language: Английский

Citations

0
Preparation and Evaluation of Meclinertant-loaded PLGA/Chitosan Nanoparticles as a Potential Treatment for Non-Small Cell Lung Cancer Using A549 Cells. DOI Creative Commons
Parth Patel,

Nicole Oyinade Shoyele,

Sunday Shoyele

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106831 - 106831

Published: March 1, 2025

Language: Английский

Citations

0
Neurotensin receptor agonist PD149163 modulates the adrenal dysfunction in mice intraperitoneally treated with lipopolysaccharide from Escherichia coli O26:B6 DOI
Aparna Tiwari,

Gyan Babu,

Banalata Mohanty

et al.

Comparative Clinical Pathology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Language: Английский

Citations

3
Ameliorative Effect of SR48692 on the Testicular and Epididymal Impairments of High-Fat Diet- Induced Swiss Albino Mice DOI

Pradeep Verma,

Himanshu Pal,

Banalata Mohanty

et al.

Toxicology International, Journal Year: 2024, Volume and Issue: unknown, P. 435 - 442

Published: July 24, 2024

This study investigated the role of Neurotensin (NT) receptor-1 antagonist SR48692 on High-Fat Diet (HFD)-induced considerable morphological alterations in testis and epididymis mice. Excessive intake fat a sedentary lifestyle are major causes metabolic comorbidities current obesogenic environment. Consumption HFD induces NT release gut, which promotes lipid absorption. Elevated is associated with imbalanced energy status could be responsible for negative impact reproductive outcomes. Male mice (n = 24) were randomly assigned, based diet into Control (CD) 4 weeks; they further divided 2 subgroups administered saline (100 μg/kg b.w.) intraperitoneally next weeks. The present findings revealed that HFD-induced obesity caused significant circulating hormone profiles leading to deterioration testicular epididymal histoarchitechture. However, co-treatment has significantly restored detrimental effect profiles, justified by improvements histoarchitechture epididymis. only group showed adverse effects studied parameters. results reported herein have efficacy actively overcome effects. Therefore, might considered therapeutic HFDinduced impairments.

Language: Английский

Citations

0