A new target for treating intervertebral disk degeneration: gut microbes DOI Creative Commons
Kaizhong Wang, Xiangyan Liu,

Huagui Huang

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 29, 2024

Intervertebral disk degeneration (IDD) is a common clinical spinal disease and one of the main causes low back pain (LBP). Generally speaking, IDD considered natural degenerative process with age. However, deepening research, people have discovered that not only related to age, but also has many factors can induce accelerate its progression. In addition, pathogenesis remains unclear, resulting in limited traditional treatment methods cannot effectively prevent treat IDD. Conservative may lead patients’ dependence on drugs, relief effect obvious. Similarly, surgical highly invasive, longer recovery time higher recurrence rate. With exploration, intestinal microorganisms are an important symbiotic microbial community human body closely occurrence development various diseases. Changes their metabolites affect body’s inflammatory response, immune regulation, metabolic processes, thereby affecting health intervertebral disk. this context, gut microbiota received considerable attention as potential target for delaying or treating This article first introduces impact microbes distal organs, then focuses three mechanisms by which influence Finally, we summarized interfering metabolites. Further understanding between will help formulate reasonable strategies achieve ideal therapeutic effects.

Language: Английский

Gut-disc axis: A Mendelian randomization study on the relationship between gut microbiota and cervical spondylosis DOI Creative Commons

Jiling Zhang,

Baodong Wang,

Peng Du

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(7), P. e41536 - e41536

Published: Feb. 14, 2025

The gut-disc axis, which refers to the interaction between gut microbiota and bone health, has recently garnered widespread attention in scientific community. However, it remains be determined whether directly induces cervical spondylosis (CS). This study employed a bidirectional 2-sample Mendelian randomization (MR) analysis explore potential causal link CS. We initially used inverse variance weighted method for preliminary estimation supplemented with other MR methods, including MR-Egger, median, mode, simple mode. Furthermore, we utilized Cochrane Q test, MR-PRESSO global MR-Egger intercept test assess possible pleiotropy heterogeneity. Ultimately, conducted investigate reverse associations identified 27 significantly associated CS, of 12 may contributing factors, while 15 have protective effects. further revealed relationship CS 24 microbiota. In this study, no significant heterogeneity or was detected. Through analysis, uncovered providing new perspectives prevention treatment especially modulation

Language: Английский

Citations

0
Association between lipid-lowering agents with intervertebral disc degeneration, sciatica and low back pain: a drug-targeted mendelian randomized study and cross-sectional observation DOI Creative Commons
Chenxu Liu,

Xinqiao Chu,

Yaning Biao

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 2, 2024

Abnormal lipid metabolism is linked to intervertebral disc degeneration (IVDD), sciatica, and low back pain (LBP), but it remains unclear whether targeted interventions can prevent these issues. This study investigated the causal effects of lipid-lowering drug use on IVDD, LBP development.

Language: Английский

Citations

2
Letter to the editor concerning “Causal associations between gut microbiota with intervertebral disk degeneration, low back pain, and sciatica: a mendelian randomization study” by Fang M, et al. (Eur Spine J [2024]; doi: 10.1007/s00586-024-08131-x) DOI

Yong-Gang Bao,

Shu Li,

Bin Wu

et al.

European Spine Journal, Journal Year: 2024, Volume and Issue: 33(7), P. 2925 - 2926

Published: June 15, 2024

Language: Английский

Citations

0
Association between lipid-lowering agents with intervertebral disc degeneration, sciatica and low back pain: A drug-targeted Mendelian randomized study and cross-sectional observation DOI Creative Commons
Chenxu Liu,

Xinqiao Chu,

Yaning Biao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 16, 2024

Abstract Background: Abnormal lipid metabolism is linked to intervertebral disc degeneration (IVDD), sciatica, and low back pain (LBP), but it remains unclear whethertargeted interventions can prevent these issues. This study investigated the causal effectsof lipid-lowering drug use on IVDD, LBP development. Methods: Single-nucleotide polymorphisms (SNPs) total cholesterol (TC), low-density-lipoprotein (LDL-C), non-high-density-lipoprotein (non-HDL-C) were obtained from Global Lipids Genetics Consortium's genome-wide association (GWAS). Genes near HMGCR, PCSK9, NPC1L1 selected represent therapeutic inhibition targets. Using Mendelian randomization (MR) studies focusing targets, we identified effects of risk developing LBP, with coronary heart disease serving as a positive control. Additionally, cross-sectional observational was performed using data National Health Nutrition Examination Survey (NHANES) further investigate connection between statin use, sample size 4343 participants. Odds ratios (ORs) corresponding 95% confidence intervals (CIs) calculated assess outcomes. Results: The NHANES-based indicated that non-statin associated an increased (OR = 1.29, CI [1.04, 1.59], P 0.019). Moreover, Inverse-variance weighting(IVW) analysis revealedthat NPC1L1-mediated reductions in TC, LDL-C, non-HDL-C concentrations decreased IVDD (P=9.956E-03; P=3.516E-02; P=1.253E-04). Similarly, PCSK9-mediated LDL-C TC lower sciatica (P=3.825E-02; P=2.709E-02). However, colocalization did not reveal any significant associations. Sensitivity confirmed stability reliability MR results. Conclusion: results suggested non-use statins positively correlated LBP. suggest could by reducing levels. PCSK9 may reduce lowering In contrast, HMGCR appears have no effect or Nonetheless, research needed verify preliminary

Language: Английский

Citations

0
A new target for treating intervertebral disk degeneration: gut microbes DOI Creative Commons
Kaizhong Wang, Xiangyan Liu,

Huagui Huang

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 29, 2024

Intervertebral disk degeneration (IDD) is a common clinical spinal disease and one of the main causes low back pain (LBP). Generally speaking, IDD considered natural degenerative process with age. However, deepening research, people have discovered that not only related to age, but also has many factors can induce accelerate its progression. In addition, pathogenesis remains unclear, resulting in limited traditional treatment methods cannot effectively prevent treat IDD. Conservative may lead patients’ dependence on drugs, relief effect obvious. Similarly, surgical highly invasive, longer recovery time higher recurrence rate. With exploration, intestinal microorganisms are an important symbiotic microbial community human body closely occurrence development various diseases. Changes their metabolites affect body’s inflammatory response, immune regulation, metabolic processes, thereby affecting health intervertebral disk. this context, gut microbiota received considerable attention as potential target for delaying or treating This article first introduces impact microbes distal organs, then focuses three mechanisms by which influence Finally, we summarized interfering metabolites. Further understanding between will help formulate reasonable strategies achieve ideal therapeutic effects.

Language: Английский

Citations

0