Microfluidic Immunosensor Platform for Sensitive Detection of Human Epidermal Growth Factor Receptor-2 Based on Enhanced Cathode Electrochemiluminescence of Bimetallic Nanoclusters

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(21), P. 8390 - 8398

Published: May 8, 2024

In this work, a microfluidic immunosensor chip was developed by incorporating technology with electrochemiluminescence (ECL) for sensitive detection of human epidermal growth factor receptor-2 (HER2). The can achieve robust reproducibility in mass production integrating multiple units series. Notably, nanoscale materials be better adapted to systems, greatly enhancing the accuracy chip. Ag@Au NCs closed glutathione (GSH) were introduced ECL system excellent and stable performance. synthesized CeO2–Au applied as coreaction promoter signal amplification system, which made result HER2 more reliable. addition, designed integrated biosensing into microchip, realizing rapid accurate its high throughput low usage. short peptide ligand NARKFKG (NRK) achieved an effective connection between antibody nanocarrier improving efficiency sensor. had storage stability sensitivity than traditional methods, wide range from 10 fg·mL–1 100 ng·mL–1 limit (LOD) 3.29 fg·mL–1. general, platform successfully constructed, providing new idea breast cancer (BC) clinical detection.

Language: Английский

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An integrated smartphone-based electrochemical detection system for highly sensitive and on-site detection of chemical oxygen demand by copper-cobalt bimetallic oxide-modified electrode

Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(6)

Published: May 27, 2024

Language: Английский

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An electrochemical biosensor using AuNPs-Ti3C2Tx and ARGET ATRP reactions as signal amplification strategies for ultra-sensitive detection of HER2 protein

Bioelectrochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108970 - 108970

Published: March 1, 2025

Language: Английский

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A comprehensive review on the recent applications of nanozymes in breast cancer therapy and diagnosis

Materials Advances, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Nanozymes have been developed as engineered nanomaterials that mimic the catalytic functions of natural enzymes.

Language: Английский

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Enzyme-free and label-free detection of HER2 in human serum based on Ag+-released hybridization chain reaction signal amplification

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 413, P. 135919 - 135919

Published: May 4, 2024

Language: Английский

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Recent advances and analytical perspectives in MXene-based electrochemical miniaturized sensors for environmental analysis and monitoring

Microchemical Journal, Journal Year: 2024, Volume and Issue: 206, P. 111433 - 111433

Published: Aug. 14, 2024

Language: Английский

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Frontiers of nanozymes: Enhancing cancer diagnosis and therapeutic strategies

Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 112043 - 112043

Published: Oct. 1, 2024

Language: Английский

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Sponge-like Au@Ru nanozyme-labeled electrochemical immunosensor platform on the trimetallic Au@Pt@Ag NPs decorated surface for the sensitive detection of HER2

Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 112538 - 112538

Published: Dec. 1, 2024

Language: Английский

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Applications of Electrochemical Analytical Techniques in HER2 Detection for Breast Cancer

International Journal of Electrochemical Science, Journal Year: 2024, Volume and Issue: unknown, P. 100813 - 100813

Published: Sept. 1, 2024

Language: Английский

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Preparation of ultra-sensitive and selective hydrogen peroxide–based colorimetric sensor using highly exfoliated g-C3N4 nanosheets with peroxidase-like activity

Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(11)

Published: Oct. 29, 2024

Language: Английский

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